ID OTX2_RAT STANDARD; PRT; 70 AA. AC Q64201; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 15-JUL-1999 (Rel. 38, Last annotation update) DE HOMEOBOX PROTEIN OTX2 (FRAGMENT). GN OTX2. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 96108898. RA Robel L., Ding M., James A.J., Lin X., Simeone A., Leckman J.F., RA Vaccarino F.M.; RT "Fibroblast growth factor 2 increases Otx2 expression in precursor RT cells from mammalian telencephalon."; RL J. Neurosci. 15:7879-7891(1995). CC -!- FUNCTION: PROBABLY PLAY A ROLE IN THE DEVELOPMENT OF THE BRAIN AND CC THE SENSE ORGANS. CAN BIND TO THE BCD TARGET SEQUENCE (BTS): 5'- CC TCTAATCCC-3' (BY SIMILARITY) MAY HAVE A ROLE IN THE FGF2-MEDIATED CC PROLIFERATION OF NEURONAL PROGENITORS, BUT NOT OF GLIAL CC PROGENITORS. INTERACTION BETWEEN BASIC FIBROBLAST GROWTH FACTOR CC (FGF2) MAY BE IMPORTANT FOR THE REGULATION OF NEUROGENESIS IN THE CC FOREBRAIN. CC -!- SUBCELLULAR LOCATION: NUCLEAR (PROBABLE). CC -!- SIMILARITY: BELONGS TO THE PAIRED FAMILY OF HOMEOBOX PROTEINS. CC "BICOID" SUBFAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; S81922; CAB33991.1; -. DR INTERPRO; IPR001356; -. DR PROSITE; PS00027; HOMEOBOX_1; PARTIAL. DR PROSITE; PS50071; HOMEOBOX_2; PARTIAL. KW Homeobox; DNA-binding; Developmental protein; Nuclear protein. FT NON_TER 1 1 FT NON_TER 70 70 SQ SEQUENCE 70 AA; 7139 MW; 4CE56B48E00E4120 CRC64; MTYTQASGYS QGYAGSTSYF GGMDCGSYLT PMHHQLPGPG ATLSPMGTNA VTSHLNQSPA SLSTQGYGAS //