ID OTX2_RAT Reviewed; 70 AA. AC Q64201; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 01-SEP-2009, entry version 58. DE RecName: Full=Homeobox protein OTX2; DE AltName: Full=Orthodenticle homolog 2; DE Flags: Fragment; GN Name=Otx2; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=96108898; PubMed=8613727; RA Robel L., Ding M., James A.J., Lin X., Simeone A., Leckman J.F., RA Vaccarino F.M.; RT "Fibroblast growth factor 2 increases Otx2 expression in precursor RT cells from mammalian telencephalon."; RL J. Neurosci. 15:7879-7891(1995). CC -!- FUNCTION: Probably plays a role in the development of the brain CC and the sense organs. Can bind to the BCD target sequence (BTS): CC 5'-TCTAATCCC-3' (By similarity). May have a role in the FGF2- CC mediated proliferation of neuronal progenitors, but not of glial CC progenitors. Interaction between basic fibroblast growth factor CC (FGF2) may be important for the regulation of neurogenesis in the CC forebrain. CC -!- SUBCELLULAR LOCATION: Nucleus (Probable). CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid CC subfamily. CC -!- SIMILARITY: Contains 1 homeobox DNA-binding domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; S81922; AAP32271.1; -; mRNA. DR IPI; IPI00231036; -. DR UniGene; Rn.35222; -. DR STRING; Q64201; -. DR Ensembl; ENSRNOT00000018109; ENSRNOP00000018109; ENSRNOG00000013406; Rattus norvegicus. DR RGD; 1305705; Otx2. DR HOVERGEN; Q64201; -. DR ArrayExpress; Q64201; -. DR GermOnline; ENSRNOG00000013406; Rattus norvegicus. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003700; F:transcription factor activity; IEA:InterPro. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR013851; Otx_TF_C. DR Pfam; PF03529; TF_Otx; 1. DR PROSITE; PS00027; HOMEOBOX_1; PARTIAL. DR PROSITE; PS50071; HOMEOBOX_2; PARTIAL. PE 2: Evidence at transcript level; KW Developmental protein; DNA-binding; Homeobox; Nucleus. FT CHAIN <1 >70 Homeobox protein OTX2. FT /FTId=PRO_0000049212. FT NON_TER 1 1 FT NON_TER 70 70 SQ SEQUENCE 70 AA; 7139 MW; 4CE56B48E00E4120 CRC64; MTYTQASGYS QGYAGSTSYF GGMDCGSYLT PMHHQLPGPG ATLSPMGTNA VTSHLNQSPA SLSTQGYGAS //