ID OTX2_RAT STANDARD; PRT; 70 AA. AC Q64201; DT 15-JUL-1998 (REL. 36, CREATED) DT 15-JUL-1998 (REL. 36, LAST SEQUENCE UPDATE) DT 15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE) DE HOMEOBOX PROTEIN OTX2 (FRAGMENT). GN OTX2. OS RATTUS NORVEGICUS (RAT). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 96108898. RA ROBEL L., DING M., JAMES A.J., LIN X., SIMEONE A., LECKMAN J.F., RA VACCARINO F.M.; RL J. NEUROSCI. 15:7879-7891(1995). CC -!- FUNCTION: PROBABLY PLAY A ROLE IN THE DEVELOPMENT OF THE BRAIN AND CC THE SENSE ORGANS. CAN BIND TO THE BCD TARGET SEQUENCE (BTS): 5'- CC TCTAATCCC-3' (BY SIMILARITY) MAY HAVE A ROLE IN THE FGF2-MEDIATED CC PROLIFERATION OF NEURONAL PROGENITORS, BUT NOT OF GLIAL CC PROGENITORS. INTERACTION BETWEEN BASIC FIBROBLAST GROWTH FACTOR CC (FGF2) MAY BE IMPORTANT FOR THE REGULATION OF NEUROGENESIS IN THE CC FOREBRAIN. CC -!- SUBCELLULAR LOCATION: NUCLEAR (PROBABLE). CC -!- SIMILARITY: BELONGS TO THE OTD FAMILY OF HOMEOBOX PROTEINS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; S81922; E257530; -. DR PROSITE; PS00027; HOMEOBOX_1; PARTIAL. DR PROSITE; PS50071; HOMEOBOX_2; PARTIAL. KW HOMEOBOX; DNA-BINDING; DEVELOPMENTAL PROTEIN; NUCLEAR PROTEIN. FT NON_TER 1 1 FT NON_TER 70 70 SQ SEQUENCE 70 AA; 7139 MW; 569E8BA8 CRC32; MTYTQASGYS QGYAGSTSYF GGMDCGSYLT PMHHQLPGPG ATLSPMGTNA VTSHLNQSPA SLSTQGYGAS //