ID OTX2_RAT Reviewed; 70 AA. AC Q64201; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 18-SEP-2019, entry version 108. DE RecName: Full=Homeobox protein OTX2; DE AltName: Full=Orthodenticle homolog 2; DE Flags: Fragment; GN Name=Otx2; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND INDUCTION BY RP FGF2. RX PubMed=8613727; DOI=10.1523/jneurosci.15-12-07879.1995; RA Robel L., Ding M., James A.J., Lin X., Simeone A., Leckman J.F., RA Vaccarino F.M.; RT "Fibroblast growth factor 2 increases Otx2 expression in precursor RT cells from mammalian telencephalon."; RL J. Neurosci. 15:7879-7891(1995). CC -!- FUNCTION: Transcription factor probably involved in the CC development of the brain and the sense organs. Can bind to the CC bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'. CC {ECO:0000250|UniProtKB:P32243}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P32243}. CC -!- DEVELOPMENTAL STAGE: Expressed in the dorsal and basal CC telencephalon, in a subpopulation of proliferating neuroblasts, CC early in development (at least from 11.5 dpc). CC {ECO:0000269|PubMed:8613727}. CC -!- INDUCTION: Up-regulated by FGF2 tretament in embryonic CC telencephalon primary cultures. {ECO:0000269|PubMed:8613727}. CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; S81922; AAP32271.1; -; mRNA. DR STRING; 10116.ENSRNOP00000064262; -. DR PaxDb; Q64201; -. DR UCSC; RGD:1305705; rat. DR RGD; 1305705; Otx2. DR eggNOG; KOG2251; Eukaryota. DR eggNOG; ENOG4111XIJ; LUCA. DR HOGENOM; HOG000082677; -. DR InParanoid; Q64201; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro. DR GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW. DR InterPro; IPR013851; Otx_TF_C. DR Pfam; PF03529; TF_Otx; 1. PE 2: Evidence at transcript level; KW Complete proteome; Developmental protein; DNA-binding; Homeobox; KW Nucleus; Reference proteome. FT CHAIN <1 >70 Homeobox protein OTX2. FT /FTId=PRO_0000049212. FT NON_TER 1 1 FT NON_TER 70 70 SQ SEQUENCE 70 AA; 7139 MW; 4CE56B48E00E4120 CRC64; MTYTQASGYS QGYAGSTSYF GGMDCGSYLT PMHHQLPGPG ATLSPMGTNA VTSHLNQSPA SLSTQGYGAS //