ID MC25A_DANRE Reviewed; 239 AA. AC Q63ZW2; DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot. DT 25-OCT-2004, sequence version 1. DT 29-APR-2015, entry version 59. DE RecName: Full=MICOS complex subunit mic25a; DE AltName: Full=Coiled-coil-helix-coiled-coil-helix domain-containing protein 6; GN Name=chchd6a; Synonyms=mic25a; ORFNames=zgc:91802; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., RA Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., RA Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., RA Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., RA Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., RA Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., RA Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., RA Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., RA Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., RA Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., RA Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., RA Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., RA Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., RA Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Component of the MICOS complex, a large protein complex CC of the mitochondrial inner membrane that plays crucial roles in CC the maintenance of crista junctions, inner membrane architecture, CC and formation of contact sites to the outer membrane. CC {ECO:0000250}. CC -!- SUBUNIT: Component of the mitochondrial contact site and cristae CC organizing system (MICOS) complex. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}; CC Lipid-anchor {ECO:0000250}. CC -!- SIMILARITY: Belongs to the MICOS complex subunit Mic19 family. CC Metazoan Mic25 subfamily. {ECO:0000305}. CC -!- SIMILARITY: Contains 1 CHCH domain. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL954678; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC082793; AAH82793.1; -; mRNA. DR RefSeq; NP_001005584.1; NM_001005584.1. DR RefSeq; XP_005162369.1; XM_005162312.1. DR UniGene; Dr.76072; -. DR STRING; 7955.ENSDARP00000007376; -. DR DNASU; 449542; -. DR Ensembl; ENSDART00000143933; ENSDARP00000116560; ENSDARG00000003206. DR GeneID; 449542; -. DR KEGG; dre:449542; -. DR CTD; 449542; -. DR ZFIN; ZDB-GENE-040930-2; chchd6a. DR eggNOG; NOG325011; -. DR GeneTree; ENSGT00390000000903; -. DR HOGENOM; HOG000252969; -. DR HOVERGEN; HBG050936; -. DR InParanoid; Q63ZW2; -. DR KO; K17564; -. DR OMA; APHKEST; -. DR OrthoDB; EOG7NW6C3; -. DR PhylomeDB; Q63ZW2; -. DR TreeFam; TF333651; -. DR NextBio; 20832661; -. DR PRO; PR:Q63ZW2; -. DR Proteomes; UP000000437; Chromosome 23. DR Bgee; Q63ZW2; -. DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB. DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB. DR GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB. DR GO; GO:0042407; P:cristae formation; ISS:UniProtKB. DR InterPro; IPR007964; DUF737. DR Pfam; PF05300; DUF737; 1. PE 2: Evidence at transcript level; KW Coiled coil; Complete proteome; Disulfide bond; Lipoprotein; Membrane; KW Mitochondrion; Mitochondrion inner membrane; Myristate; KW Reference proteome. FT INIT_MET 1 1 Removed. {ECO:0000255}. FT CHAIN 2 239 MICOS complex subunit mic25a. FT /FTId=PRO_0000416910. FT DOMAIN 188 229 CHCH. FT COILED 79 166 {ECO:0000255}. FT LIPID 2 2 N-myristoyl glycine. {ECO:0000255}. FT DISULFID 195 226 {ECO:0000250}. FT DISULFID 205 216 {ECO:0000250}. SQ SEQUENCE 239 AA; 27540 MW; A215A00FAD26DBEA CRC64; MGSGESTTRR VSFGLDEDDR VRILRGVKLS EDVLQRMRNT NADPRPPANN KENQGHQTRT PSTSDAQAPK TQAKTTFPDS KEELKKRYEQ QQAIIQEELA RIARKEREAA RQDISRAVQR ERAQTRQESE RAKQLGKQLD KKEAELKALE AFYQEQITQL EKKNEERFRM SAEQFHAAAT RSEANIKARN VEPVCLNLQA QILNCYRENR EQTLQCSDLA KEYMQCINAA KKNLLVNHG //