ID   FOXQ1_RAT               Reviewed;         399 AA.
AC   Q63244;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 3.
DT   11-JUL-2012, entry version 98.
DE   RecName: Full=Forkhead box protein Q1;
DE   AltName: Full=HNF-3/forkhead-like protein 1;
DE            Short=HFH-1;
DE   AltName: Full=Hepatocyte nuclear factor 3 forkhead homolog 1;
GN   Name=Foxq1; Synonyms=Hfh1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-65.
RC   STRAIN=Wistar;
RX   PubMed=15326124; DOI=10.1167/iovs.04-0302;
RA   Ahmed F., Torrado M., Zinovieva R.D., Senatorov V.V., Wistow G.,
RA   Tomarev S.I.;
RT   "Gene expression profile of the rat eye iridocorneal angle: NEIBank
RT   expressed sequence tag analysis.";
RL   Invest. Ophthalmol. Vis. Sci. 45:3081-3090(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 8-399.
RC   STRAIN=Sprague-Dawley; TISSUE=Lung;
RX   MEDLINE=93248207; PubMed=7683413; DOI=10.1073/pnas.90.9.3948;
RA   Clevidence D.E., Overdier D.G., Tao W., Qian X., Pani L., Lai E.,
RA   Costa R.H.;
RT   "Identification of nine tissue-specific transcription factors of the
RT   hepatocyte nuclear factor 3/forkhead DNA-binding-domain family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:3948-3952(1993).
CC   -!- FUNCTION: Plays a role in hair follicle differentiation (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Contains 1 fork-head DNA-binding domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA74561.1; Type=Frameshift; Positions=12, 285, 326;
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DR   EMBL; DV214562; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; L13201; AAA74561.1; ALT_FRAME; mRNA.
DR   IPI; IPI00206919; -.
DR   PIR; I60916; I60916.
DR   RefSeq; NP_074049.2; NM_022858.2.
DR   UniGene; Rn.10101; -.
DR   PDB; 1KQ8; NMR; -; A=114-213.
DR   PDBsum; 1KQ8; -.
DR   ProteinModelPortal; Q63244; -.
DR   SMR; Q63244; 120-194.
DR   PRIDE; Q63244; -.
DR   GeneID; 64826; -.
DR   KEGG; rno:64826; -.
DR   UCSC; RGD:621572; rat.
DR   CTD; 94234; -.
DR   RGD; 621572; Foxq1.
DR   HOVERGEN; HBG051658; -.
DR   KO; K09410; -.
DR   EvolutionaryTrace; Q63244; -.
DR   NextBio; 613734; -.
DR   Genevestigator; Q63244; -.
DR   GO; GO:0005667; C:transcription factor complex; IBA:RefGenome.
DR   GO; GO:0043028; F:cysteine-type endopeptidase regulator activity involved in apoptotic process; IBA:RefGenome.
DR   GO; GO:0008301; F:DNA binding, bending; IBA:RefGenome.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.
DR   GO; GO:0010843; F:promoter binding; IBA:RefGenome.
DR   GO; GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.
DR   GO; GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.
DR   GO; GO:0016563; F:transcription activator activity; IBA:RefGenome.
DR   GO; GO:0006309; P:apoptotic DNA fragmentation; IBA:RefGenome.
DR   GO; GO:0009790; P:embryo development; IBA:RefGenome.
DR   GO; GO:0031069; P:hair follicle morphogenesis; IBA:RefGenome.
DR   GO; GO:0007389; P:pattern specification process; IBA:RefGenome.
DR   GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IBA:RefGenome.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.
DR   GO; GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
DR   Gene3D; G3DSA:1.10.10.10; Wing_hlx_DNA_bd; 1.
DR   InterPro; IPR001766; TF_fork_head.
DR   InterPro; IPR018122; TF_fork_head_CS.
DR   InterPro; IPR011991; WHTH_trsnscrt_rep_DNA-bd.
DR   Pfam; PF00250; Fork_head; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN         1    399       Forkhead box protein Q1.
FT                                /FTId=PRO_0000091892.
FT   DNA_BIND    114    205       Fork-head.
FT   CONFLICT     41     41       G -> S (in Ref. 1; DV214562).
FT   CONFLICT     55     58       SGAG -> RSAV (in Ref. 1; DV214562).
FT   CONFLICT     62     62       G -> S (in Ref. 1; DV214562).
FT   HELIX       121    128
FT   STRAND      131    134
FT   HELIX       138    148
FT   HELIX       152    154
FT   HELIX       160    170
FT   STRAND      183    185
SQ   SEQUENCE   399 AA;  41079 MW;  DFFFDBBA7B04F780 CRC64;
     MKLEVFAPRA AHGDKMGSDL EGAGSSDVPS PLSAAGDDSL GSDGDCAANS PAAGSGAGDL
     EGGGGERNSS GGASTQDDPE VTDGSRTQAS PVGPCAGSVG GGEGARSKPY TRRPKPPYSY
     IALIAMAIRD SAGGRLTLAE INEYLMGKFP FFRGSYTGWR NSVRHNLSLN DCFVKVLRDP
     SRPWGKDNYW MLNPNSEYTF ADGVFRRRRK RLSHRTTVSA SGYGGGSPPG PAGTPQPAPT
     AGSSPIARSP ARQEEGSSPA SKFSSSFAID SILSKPFRSR RDGTPALGVQ LPWSAAPCPP
     LRAYPALLPA SSGGALLPLC AYGAAEPTLL ASRGAEVQPA APLFVAPLST AAPAKPFRGP
     ETAGAAHLYC PLRLPTALQA AAACGPGPHL SYRVETLLA
//