ID   CALRL_RAT               Reviewed;         464 AA.
AC   Q63118;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   05-APR-2011, entry version 80.
DE   RecName: Full=Calcitonin gene-related peptide type 1 receptor;
DE            Short=CGRP type 1 receptor;
DE   AltName: Full=Calcitonin receptor-like receptor;
DE   Flags: Precursor;
GN   Name=Calcrl; Synonyms=Cgrpr;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Lung;
RX   MEDLINE=94037821; PubMed=8222502;
RA   Njuki F., Nicholl C.G., Howard A., Mak J.C., Barnes P.J., Girgis S.I.,
RA   Legon S.;
RT   "A new calcitonin-receptor-like sequence in rat pulmonary blood
RT   vessels.";
RL   Clin. Sci. 85:385-388(1993).
CC   -!- FUNCTION: Receptor for calcitonin-gene-related peptide (CGRP)
CC       together with RAMP1 and receptor for adrenomedullin together with
CC       RAMP2 or RAMP3 (By similarity). The activity of this receptor is
CC       mediated by G proteins which activate adenylyl cyclase (By
CC       similarity).
CC   -!- SUBUNIT: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3 (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X70658; CAA49997.1; -; mRNA.
DR   IPI; IPI00205777; -.
DR   PIR; I60194; I60194.
DR   RefSeq; NP_036849.1; NM_012717.1.
DR   UniGene; Rn.11202; -.
DR   ProteinModelPortal; Q63118; -.
DR   SMR; Q63118; 32-131.
DR   STRING; Q63118; -.
DR   PhosphoSite; Q63118; -.
DR   Ensembl; ENSRNOT00000006462; ENSRNOP00000006462; ENSRNOG00000004622.
DR   GeneID; 25029; -.
DR   KEGG; rno:25029; -.
DR   UCSC; L27487; rat.
DR   CTD; 25029; -.
DR   RGD; 2255; Calcrl.
DR   eggNOG; roNOG05842; -.
DR   GeneTree; ENSGT00580000081433; -.
DR   HOVERGEN; HBG102129; -.
DR   InParanoid; Q63118; -.
DR   OMA; SIVTIIH; -.
DR   OrthoDB; EOG4WSW9H; -.
DR   PhylomeDB; Q63118; -.
DR   NextBio; 605171; -.
DR   ArrayExpress; Q63118; -.
DR   Genevestigator; Q63118; -.
DR   GermOnline; ENSRNOG00000004622; Rattus norvegicus.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004948; F:calcitonin receptor activity; IMP:RGD.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; IMP:RGD.
DR   GO; GO:0006937; P:regulation of muscle contraction; IMP:RGD.
DR   InterPro; IPR003287; GCPR_2_calcitonin_rcpt-like.
DR   InterPro; IPR017981; GPCR_2-like.
DR   InterPro; IPR003289; GPCR_2_CGRP1_rcpt.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR   PANTHER; PTHR12011:SF67; Calctnin_rcpt; 1.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF02793; HRM; 1.
DR   PRINTS; PR01351; CGRPRECEPTOR.
DR   PRINTS; PR01350; CTRFAMILY.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   SMART; SM00008; HormR; 1.
DR   PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR   PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Signal; Transducer; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     23       Potential.
FT   CHAIN        24    464       Calcitonin gene-related peptide type 1
FT                                receptor.
FT                                /FTId=PRO_0000012813.
FT   TOPO_DOM     24    146       Extracellular (Potential).
FT   TRANSMEM    147    166       Helical; Name=1; (Potential).
FT   TOPO_DOM    167    173       Cytoplasmic (Potential).
FT   TRANSMEM    174    193       Helical; Name=2; (Potential).
FT   TOPO_DOM    194    213       Extracellular (Potential).
FT   TRANSMEM    214    236       Helical; Name=3; (Potential).
FT   TOPO_DOM    237    253       Cytoplasmic (Potential).
FT   TRANSMEM    254    273       Helical; Name=4; (Potential).
FT   TOPO_DOM    274    289       Extracellular (Potential).
FT   TRANSMEM    290    313       Helical; Name=5; (Potential).
FT   TOPO_DOM    314    336       Cytoplasmic (Potential).
FT   TRANSMEM    337    354       Helical; Name=6; (Potential).
FT   TOPO_DOM    355    366       Extracellular (Potential).
FT   TRANSMEM    367    388       Helical; Name=7; (Potential).
FT   TOPO_DOM    389    464       Cytoplasmic (Potential).
FT   CARBOHYD     30     30       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     66     66       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    118    118       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    123    123       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    128    128       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    129    129       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   464 AA;  53329 MW;  7373EC94B0FBC33C CRC64;
     MMDKKCTLCF LFLLLLNMAL IAAESEEGAN QTDLGVTRNK IMTAQYECYQ KIMQDPIQQG
     EGLYCNRTWD GWLCWNDVAA GTESMQYCPD YFQDFDPSEK VTKICDQDGN WFRHPDSNRT
     WTNYTLCNNS THEKVKTALN LFYLTIIGHG LSIASLIISL IIFFYFKSLS CQRITLHKNL
     FFSFVCNSIV TIIHLTAVAN NQALVATNPV SCKVSQFIHL YLMGCNYFWM LCEGIYLHTL
     IVVAVFAEKQ HLMWYYFLGW GFPLLPACIH AIARSLYYND NCWISSDTHL LYIIHGPICA
     ALLVNLFFLL NIVRVLITKL KVTHQAESNL YMKAVRATLI LVPLLGIEFV LFPWRPEGKV
     AEEVYDYVMH ILMHYQGLLV STIFCFFNGE VQAILRRNWN QYKIQFGNGF SHSDALRSAS
     YTVSTISDVQ GYSHDCPTEH LNGKSIQDIE NVALKPEKMY DLVM
//