ID Q61892_MOUSE Unreviewed; 365 AA. AC Q61892; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 24-JAN-2024, entry version 154. DE SubName: Full=mRNA {ECO:0000313|EMBL:AAA39739.1}; GN Name=H2-D1 {ECO:0000313|MGI:MGI:95896}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAA39739.1}; RN [1] {ECO:0000313|EMBL:AAA39739.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=B10.SM {ECO:0000313|EMBL:AAA39739.1}; RC TISSUE=Spleen {ECO:0000313|EMBL:AAA39739.1}; RX PubMed=1370689; DOI=10.1084/jem.175.2.583; RA Cai Z., Pease L.R.; RT "Structural and functional analysis of three D/L-like class I molecules RT from H-2v: indications of an ancestral family of D/L genes."; RL J. Exp. Med. 175:583-596(1992). RN [2] {ECO:0000313|EMBL:AAA39739.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=B10.SM {ECO:0000313|EMBL:AAA39739.1}; RC TISSUE=Spleen {ECO:0000313|EMBL:AAA39739.1}; RX PubMed=1730883; RA Pullen J.K., Horton R.M., Cai Z., Pease L.R.; RT "Structural diversity of the classical H-2 genes: K, D, and L."; RL J. Immunol. 148:953-967(1992). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|ARBA:ARBA00002297}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|ARBA:ARBA00006909, ECO:0000256|RuleBase:RU004439}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M69067; AAA39739.1; -; mRNA. DR AlphaFoldDB; Q61892; -. DR PeptideAtlas; Q61892; -. DR AGR; MGI:95896; -. DR MGI; MGI:95896; H2-D1. DR ChiTaRS; H2-D1; mouse. DR GO; GO:0098553; C:lumenal side of endoplasmic reticulum membrane; IEA:UniProt. DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProt. DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR CDD; cd12087; TM_EGFR-like; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR PANTHER; PTHR16675:SF251; CLASS IB MHC ANTIGEN QA-2-RELATED; 1. DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunity {ECO:0000256|ARBA:ARBA00022859}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|ARBA:ARBA00022451}; Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1..24 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 25..365 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5004265582" FT TRANSMEM 310..333 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 209..297 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT REGION 343..365 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 365 AA; 40910 MW; 2A995EE6384EE480 CRC64; MGAMAPRTLL LLLAAALAPT QTRAGPHSLR YFTTAVSRPG LGEPRFISVG YVDNTEFVRF DSDAENPRDE PRARWMEQVE PEYWERNTRR AKGHEQWFRV SLRNLLGYYN QSAGGSHTLQ WMSGCDVGSD GRLLRGYEQY AYDGCDYIAL NEDLKTWTAA DMAALITKHK WEQAGAAEYY RAYLEGECVE WLLRHLKNGN ATLLRTDSPK AHVTHHPRSK GEVTLKCWAL GFYPADITLT WQLNGEELTQ DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCHVHHEGL PEPLTLRWGR WEPPPSTDSY MVIVAVLGVL GAMAIIGAVV AFVMKRRRNT GGKGGDYALA PGSQSSEMSL RDCKA //