ID COPT2_ORYSJ Reviewed; 151 AA. AC Q60EN8; DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot. DT 23-NOV-2004, sequence version 1. DT 12-AUG-2020, entry version 83. DE RecName: Full=Copper transporter 2; DE Short=OsCOPT2; GN Name=COPT2; OrderedLocusNames=Os05g0424700, LOC_Os05g35050; GN ORFNames=OJ1212_B02.11; OS Oryza sativa subsp. japonica (Rice). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade; OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa. OX NCBI_TaxID=39947; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Nipponbare; RX PubMed=16261349; DOI=10.1007/s00438-005-0039-y; RA Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J., RA Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F., RA Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.; RT "A fine physical map of the rice chromosome 5."; RL Mol. Genet. Genomics 274:337-345(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Nipponbare; RX PubMed=16100779; DOI=10.1038/nature03895; RG International rice genome sequencing project (IRGSP); RT "The map-based sequence of the rice genome."; RL Nature 436:793-800(2005). RN [3] RP GENOME REANNOTATION. RC STRAIN=cv. Nipponbare; RX PubMed=18089549; DOI=10.1093/nar/gkm978; RG The rice annotation project (RAP); RT "The rice annotation project database (RAP-DB): 2008 update."; RL Nucleic Acids Res. 36:D1028-D1033(2008). RN [4] RP GENOME REANNOTATION. RC STRAIN=cv. Nipponbare; RX PubMed=24280374; DOI=10.1186/1939-8433-6-4; RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R., RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L., RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H., RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.; RT "Improvement of the Oryza sativa Nipponbare reference genome using next RT generation sequence and optical map data."; RL Rice 6:4-4(2013). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Nipponbare; RX PubMed=12869764; DOI=10.1126/science.1081288; RG The rice full-length cDNA consortium; RT "Collection, mapping, and annotation of over 28,000 cDNA clones from RT japonica rice."; RL Science 301:376-379(2003). RN [6] RP FUNCTION, INTERACTION WITH SWEET11 AND COPT1, SUBCELLULAR LOCATION, AND RP DISRUPTION PHENOTYPE. RC STRAIN=cv. Mudanjiang 8, and cv. Zhonghua 11; RX PubMed=20852017; DOI=10.1105/tpc.110.078022; RA Antony G., Zhou J., Huang S., Li T., Liu B., White F., Yang B., Yuan M., RA Chu Z., Li X., Xu C., Wang S.; RT "Rice xa13 recessive resistance to bacterial blight is defeated by RT induction of the disease susceptibility gene Os-11N3. The bacterial RT pathogen Xanthomonas oryzae overcomes rice defenses by regulating host RT copper redistribution."; RL Plant Cell 22:3164-3176(2010). CC -!- FUNCTION: Involved in the transport of copper, in cooperation with CC SWEET11 and COPT1. Contributes to the removal of copper (Cu) from CC xylem, and thus to the sensitivity toward bacterial pathogens such as CC X.oryzae pv. oryzae (Xoo). {ECO:0000269|PubMed:20852017}. CC -!- SUBUNIT: Self-interacts. Interacts with SWEET11 and COPT1. CC {ECO:0000269|PubMed:20852017}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20852017}; CC Multi-pass membrane protein {ECO:0000269|PubMed:20852017}. CC -!- DISRUPTION PHENOTYPE: Reduced copper transport ability, increase in CC copper content of the xylem, and enhanced resistance against X.oryzae CC pv. oryzae (Xoo) PXO99. {ECO:0000269|PubMed:20852017}. CC -!- SIMILARITY: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. CC SLC31A subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC109595; AAV24776.1; -; Genomic_DNA. DR EMBL; AP008211; BAF17508.1; -; Genomic_DNA. DR EMBL; AP014961; BAS94104.1; -; Genomic_DNA. DR EMBL; AK107848; BAG98176.1; -; mRNA. DR RefSeq; XP_015638992.1; XM_015783506.1. DR SMR; Q60EN8; -. DR STRING; 4530.OS05T0424700-01; -. DR PaxDb; Q60EN8; -. DR EnsemblPlants; Os05t0424700-01; Os05t0424700-01; Os05g0424700. DR GeneID; 4338846; -. DR Gramene; Os05t0424700-01; Os05t0424700-01; Os05g0424700. DR KEGG; osa:4338846; -. DR eggNOG; KOG3386; Eukaryota. DR HOGENOM; CLU_079690_1_0_1; -. DR InParanoid; Q60EN8; -. DR OMA; GGHMHGM; -. DR OrthoDB; 1389393at2759; -. DR Proteomes; UP000000763; Chromosome 5. DR Proteomes; UP000059680; Chromosome 5. DR ExpressionAtlas; Q60EN8; baseline and differential. DR Genevisible; Q60EN8; OS. DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB. DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB. DR GO; GO:0005375; F:copper ion transmembrane transporter activity; IMP:UniProtKB. DR GO; GO:0043621; F:protein self-association; IDA:UniProtKB. DR GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:UniProtKB. DR GO; GO:0006878; P:cellular copper ion homeostasis; IBA:GO_Central. DR GO; GO:0006825; P:copper ion transport; IMP:UniProtKB. DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW. DR InterPro; IPR007274; Cop_transporter. DR PANTHER; PTHR12483; PTHR12483; 1. DR Pfam; PF04145; Ctr; 1. PE 1: Evidence at protein level; KW Cell membrane; Copper; Copper transport; Ion transport; Membrane; KW Plant defense; Reference proteome; Transmembrane; Transmembrane helix; KW Transport. FT CHAIN 1..151 FT /note="Copper transporter 2" FT /id="PRO_0000399999" FT TRANSMEM 42..62 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 97..117 FT /note="Helical" FT /evidence="ECO:0000255" SQ SEQUENCE 151 AA; 16269 MW; C2D355A7BADAE20B CRC64; MDMGGNGMAM PPPPAPVKKA RYMHMTFFWG KNTEVLFTLW PGARGGMYAL AILFMFALAV LLEFRGYRVL EARLARRRAP RAAAALRTAV HAVRVGVAYL IMLALMSFNG GVFLAIVAGH AAGFLAFRAG LCGGGPAPPL EEDRKNDPVC C //