ID COPT2_ORYSJ Reviewed; 151 AA. AC Q60EN8; DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot. DT 23-NOV-2004, sequence version 1. DT 09-JAN-2013, entry version 45. DE RecName: Full=Copper transporter 2; DE Short=OsCOPT2; GN Name=COPT2; OrderedLocusNames=Os05g0424700, LOC_Os05g35050; GN ORFNames=OJ1212_B02.11; OS Oryza sativa subsp. japonica (Rice). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade; OC Ehrhartoideae; Oryzeae; Oryza. OX NCBI_TaxID=39947; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Nipponbare; RX PubMed=16261349; DOI=10.1007/s00438-005-0039-y; RA Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J., RA Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., RA Shaw J.-F., Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.; RT "A fine physical map of the rice chromosome 5."; RL Mol. Genet. Genomics 274:337-345(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Nipponbare; RX PubMed=16100779; DOI=10.1038/nature03895; RG International rice genome sequencing project (IRGSP); RT "The map-based sequence of the rice genome."; RL Nature 436:793-800(2005). RN [3] RP GENOME REANNOTATION. RC STRAIN=cv. Nipponbare; RX PubMed=18089549; DOI=10.1093/nar/gkm978; RG The rice annotation project (RAP); RT "The rice annotation project database (RAP-DB): 2008 update."; RL Nucleic Acids Res. 36:D1028-D1033(2008). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Nipponbare; RX MEDLINE=22752273; PubMed=12869764; DOI=10.1126/science.1081288; RG The rice full-length cDNA consortium; RT "Collection, mapping, and annotation of over 28,000 cDNA clones from RT japonica rice."; RL Science 301:376-379(2003). RN [5] RP FUNCTION, INTERACTION WITH SWEET11 AND COPT1, SUBCELLULAR LOCATION, RP AND DISRUPTION PHENOTYPE. RC STRAIN=cv. Mudanjiang 8, and cv. Zhonghua 11; RX PubMed=20852017; DOI=10.1105/tpc.110.078022; RA Antony G., Zhou J., Huang S., Li T., Liu B., White F., Yang B., RA Yuan M., Chu Z., Li X., Xu C., Wang S.; RT "Rice xa13 recessive resistance to bacterial blight is defeated by RT induction of the disease susceptibility gene Os-11N3. The bacterial RT pathogen Xanthomonas oryzae overcomes rice defenses by regulating host RT copper redistribution."; RL Plant Cell 22:3164-3176(2010). CC -!- FUNCTION: Involved in the transport of copper, in cooperation with CC SWEET11 and COPT1. Contributes to the removal of copper (Cu) from CC xylem, and thus to the sensitivity toward bacterial pathogens such CC as X.oryzae pv. oryzae (Xoo). CC -!- SUBUNIT: Self-interacts. Interacts with SWEET11 and COPT1. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- DISRUPTION PHENOTYPE: Reduced copper transport ability, inncrease CC in copper content of the xylem, and enhanced resistance against CC X.oryzae pv. oryzae (Xoo) PXO99. CC -!- SIMILARITY: Belongs to the copper transporter (Ctr) (TC 1.A.56) CC family. SLC31A subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC109595; AAV24776.1; -; Genomic_DNA. DR EMBL; AP008211; BAF17508.1; -; Genomic_DNA. DR EMBL; AK107848; BAG98176.1; -; mRNA. DR RefSeq; NP_001055594.1; NM_001062129.1. DR UniGene; Os.31094; -. DR EnsemblPlants; LOC_Os05g35050.1; LOC_Os05g35050.1; LOC_Os05g35050. DR GeneID; 4338846; -. DR KEGG; osa:4338846; -. DR Gramene; Q60EN8; -. DR eggNOG; KOG3386; -. DR OMA; LAVIVEW; -. DR ProtClustDB; CLSN2691893; -. DR GO; GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. DR GO; GO:0005375; F:copper ion transmembrane transporter activity; IMP:UniProtKB. DR GO; GO:0043621; F:protein self-association; IDA:UniProtKB. DR GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:UniProtKB. DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW. DR InterPro; IPR007274; Cop_transporter. DR PANTHER; PTHR12483; PTHR12483; 1. DR Pfam; PF04145; Ctr; 2. PE 1: Evidence at protein level; KW Cell membrane; Complete proteome; Copper; Copper transport; KW Ion transport; Membrane; Plant defense; Transmembrane; KW Transmembrane helix; Transport. FT CHAIN 1 151 Copper transporter 2. FT /FTId=PRO_0000399999. FT TRANSMEM 42 62 Helical; (Potential). FT TRANSMEM 97 117 Helical; (Potential). SQ SEQUENCE 151 AA; 16269 MW; C2D355A7BADAE20B CRC64; MDMGGNGMAM PPPPAPVKKA RYMHMTFFWG KNTEVLFTLW PGARGGMYAL AILFMFALAV LLEFRGYRVL EARLARRRAP RAAAALRTAV HAVRVGVAYL IMLALMSFNG GVFLAIVAGH AAGFLAFRAG LCGGGPAPPL EEDRKNDPVC C //