ID   DBP_MOUSE               Reviewed;         325 AA.
AC   Q60925; Q8VCX3;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 2.
DT   23-JAN-2007, entry version 51.
DE   D site-binding protein (Albumin D box-binding protein) (Albumin D-
DE   element-binding protein).
GN   Name=Dbp;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129/Sv; TISSUE=Liver;
RA   Lee Y.H., Oguchi H., Gonzalez F.J.;
RL   Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   CIRCADIAN INDUCTION.
RX   PubMed=8617210;
RA   Fonjallaz P., Ossipow V., Wanner G., Schibler U.;
RT   "The two PAR leucine zipper proteins, TEF and DBP, display similar
RT   circadian and tissue-specific expression, but have different target
RT   promoter preferences.";
RL   EMBO J. 15:351-362(1996).
RN   [4]
RP   INVOLVEMENT IN EPILEPSY.
RX   PubMed=15175240; DOI=10.1101/gad.301404;
RA   Gachon F., Fonjallaz P., Damiola F., Gos P., Kodama T., Zakany J.,
RA   Duboule D., Petit B., Tafti M., Schibler U.;
RT   "The loss of circadian PAR bZip transcription factors results in
RT   epilepsy.";
RL   Genes Dev. 18:1397-1412(2004).
CC   -!- FUNCTION: This transcriptional activator recognizes and binds to
CC       the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such
CC       as albumin, CYP2A4 and CYP2A5. It is not essential for circadian
CC       rhythm generation, but modulates important clock output genes. May
CC       be a direct target for regulation by the circadian pacemaker
CC       component clock. May affect circadian period and sleep regulation
CC       (By similarity).
CC   -!- SUBUNIT: Binds DNA as a homodimer or a heterodimer. Can form a
CC       heterodimer with TEF (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Expressed in the suprachiasmatic nuclei (SCN)
CC       and in most peripheral tissues, with a strong circadian
CC       rhythmicity.
CC   -!- INDUCTION: Accumulates according to a robust circadian rhythm in
CC       liver and kidney. In liver nuclei, the amplitude of daily
CC       oscillation has been estimated to be >50-fold, and 2-fold in the
CC       brain.
CC   -!- MISCELLANEOUS: Mice deficient for all three PAR bZIP proteins
CC       (DBP, HLF and TEF) display a dramatically shortened life span and
CC       are highly susceptible to generalized spontaneous and audiogenic
CC       epilepsies (due for example to the noise of a vacuum cleaner) that
CC       are frequently lethal. The down-regulation of pyridoxal kinase
CC       (Pdxk) expression in these mice may participate in this seizure
CC       phenotype.
CC   -!- SIMILARITY: Belongs to the bZIP family. PAR subfamily.
CC   -!- SIMILARITY: Contains 1 bZIP domain.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U29762; AAA73924.1; -; Genomic_DNA.
DR   EMBL; BC018323; AAH18323.1; -; mRNA.
DR   Ensembl; ENSMUSG00000059824; Mus musculus.
DR   KEGG; mmu:13170; -.
DR   MGI; MGI:94866; Dbp.
DR   ArrayExpress; Q60925; -.
DR   GermOnline; ENSMUSG00000059824; Mus musculus.
DR   GO; GO:0007623; P:circadian rhythm; TAS:MGI.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; TAS:MGI.
DR   InterPro; IPR011700; bZIP_2.
DR   InterPro; IPR004827; TF_bZIP.
DR   Pfam; PF07716; bZIP_2; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; FALSE_NEG.
KW   Activator; Biological rhythms; DNA-binding; Nuclear protein;
KW   Transcription; Transcription regulation.
FT   CHAIN         1    325       D site-binding protein.
FT                                /FTId=PRO_0000076508.
FT   DOMAIN      290    304       Leucine-zipper.
FT   DNA_BIND    258    277       Basic motif.
FT   COMPBIAS    129    135       Poly-Pro.
FT   COMPBIAS    156    161       Poly-Ser.
FT   COMPBIAS    188    239       Pro-rich (proline/acidic region (PAR)).
FT   CONFLICT     60     60       S -> T (in Ref. 1).
FT   CONFLICT    109    109       L -> F (in Ref. 1).
SQ   SEQUENCE   325 AA;  34380 MW;  B2B2A3E091845A16 CRC64;
     MARPLSDRTP GPLLLGGPAG APPGGGALLG LRSLLQGNSK PKEPASCLLK EKERKATLPS
     APVPGPGLET AGPADAPSGA VSGGGSPRGR SGPVAGPSLF APLLWERTLP FGDVEYVDLD
     AFLLEHGLPP SPPPPGGLSP APSPARTPAP SPGPGSCSSS SPRSSPGHAP ARATLGAAGG
     HRAGLTSRDT PSPVDPDTVE VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI
     MKKARKVQVP EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE
     VVAVRQELSH YRAVLSRYQA QHGTL
//