ID LC4S_MOUSE STANDARD; PRT; 150 AA. AC Q60860; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 30-MAY-2000 (Rel. 39, Last annotation update) DE LEUKOTRIENE C4 SYNTHASE (EC 2.5.1.37) (LEUKOTRIENE-C(4) SYNTHASE) DE (LTC4 SYNTHASE). GN LTC4S. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 98000279. RA Penrose J.F., Baldasaro M.H., Webster M., Xu K., Austen K.F., RA Lam B.K.; RT "Molecular cloning of the gene for mouse leukotriene-C4 synthase."; RL Eur. J. Biochem. 248:807-813(1997). CC -!- FUNCTION: CATALYZES THE CONJUGATION OF LEUKOTRIENE A4 WITH REDUCED CC GLUTATHIONE TO FORM LEUKOTRIENE C4. CC -!- CATALYTIC ACTIVITY: LEUKOTRIENE A4 + GLUTATHIONE = LEUKOTRIENE C4 CC + H(2)O. CC -!- SUBUNIT: HOMODIMER (BY SIMILARITY). CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. CC -!- SIMILARITY: BELONGS TO THE FLAP/LTC4S FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U27195; AAA75042.1; -. DR MGD; MGI:107498; LTC4S. DR INTERPRO; IPR001129; -. DR PFAM; PF01124; MAPEG; 1. DR PROSITE; PS01297; FLAP_GST2_LTC4S; 1. KW Transferase; Transmembrane; Leukotriene biosynthesis. FT TRANSMEM 7 27 POTENTIAL. FT TRANSMEM 68 88 POTENTIAL. FT TRANSMEM 115 135 POTENTIAL. SQ SEQUENCE 150 AA; 16814 MW; 120ABC53892189C0 CRC64; MKDEVALLAT VTLVGVLLQA YFSLQVISAR RAFHVSPPLT SGPPEFERVF RAQVNCSEYF PLFLATLWVA GIFFHEGAAA LCGLFYLFAR LRYFQGYARS AQLRLTPLYA SARALWLLVA MAALGLLVHF LPGTLRTALF RWLQMLLPMA //