ID LC4S_MOUSE STANDARD; PRT; 150 AA. AC Q60860; DT 01-NOV-1997 (REL. 35, CREATED) DT 01-NOV-1997 (REL. 35, LAST SEQUENCE UPDATE) DT 15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE) DE LEUKOTRIENE C4 SYNTHASE (EC 2.5.1.37) (LEUKOTRIENE-C(4) SYNTHASE) DE (LTC4 SYNTHASE). GN LTC4S. OS MUS MUSCULUS (MOUSE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA; OC RODENTIA; SCIUROGNATHI; MURIDAE; MURINAE; MUS. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 98000279. RA PENROSE J.F., BALDASARO M.H., WEBSTER M., XU K., AUSTEN K.F., RA LAM B.K.; RT "Molecular cloning of the gene for mouse leukotriene-C4 synthase."; RL EUR. J. BIOCHEM. 248:807-813(1997). CC -!- FUNCTION: CATALYZES THE CONJUGATION OF LEUKOTRIENE A4 WITH REDUCED CC GLUTATHIONE TO FORM LEUKOTRIENE C4. CC -!- CATALYTIC ACTIVITY: LEUKOTRIENE A4 + GLUTATHIONE = LEUKOTRIENE C4 CC + H(2)O. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. CC -!- SUBUNIT: HOMODIMER (BY SIMILARITY). CC -!- SIMILARITY: BELONGS TO THE FLAP/LTC4S FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U27195; G973222; -. DR MGD; MGI:107498; LTC4S. DR PROSITE; PS01297; FLAP_GST2_LTC4S; 1. DR PFAM; PF01124; FLAP; 1. KW TRANSFERASE; TRANSMEMBRANE; LEUKOTRIENE BIOSYNTHESIS. FT TRANSMEM 7 27 POTENTIAL. FT TRANSMEM 68 88 POTENTIAL. FT TRANSMEM 115 135 POTENTIAL. SQ SEQUENCE 150 AA; 16814 MW; 87517D00 CRC32; MKDEVALLAT VTLVGVLLQA YFSLQVISAR RAFHVSPPLT SGPPEFERVF RAQVNCSEYF PLFLATLWVA GIFFHEGAAA LCGLFYLFAR LRYFQGYARS AQLRLTPLYA SARALWLLVA MAALGLLVHF LPGTLRTALF RWLQMLLPMA //