ID LC4S_MOUSE STANDARD; PRT; 150 AA. AC Q60860; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Leukotriene C4 synthase (EC 4.4.1.20) (Leukotriene-C(4) synthase) DE (LTC4 synthase). GN LTC4S. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=98000279; PubMed=9342232; RA Penrose J.F., Baldasaro M.H., Webster M., Xu K., Austen K.F., RA Lam B.K.; RT "Molecular cloning of the gene for mouse leukotriene-C4 synthase."; RL Eur. J. Biochem. 248:807-813(1997). CC -!- FUNCTION: Catalyzes the conjugation of leukotriene A4 with reduced CC glutathione to form leukotriene C4. CC -!- CATALYTIC ACTIVITY: Leukotriene C4 = leukotriene A4 + glutathione. CC -!- SUBUNIT: Homodimer (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: Belongs to the MAPEG family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U27195; AAA75042.1; -. DR PIR; S68961; S68961. DR MGD; MGI:107498; Ltc4s. DR InterPro; IPR001446; 5LipoxygnseAP. DR InterPro; IPR001129; MAPEG. DR Pfam; PF01124; MAPEG; 1. DR PRINTS; PR00488; 5LPOXGNASEAP. DR PROSITE; PS01297; FLAP_GST2_LTC4S; 1. KW Lyase; Transmembrane; Leukotriene biosynthesis. FT TRANSMEM 7 27 Potential. FT TRANSMEM 68 88 Potential. FT TRANSMEM 115 135 Potential. SQ SEQUENCE 150 AA; 16814 MW; 120ABC53892189C0 CRC64; MKDEVALLAT VTLVGVLLQA YFSLQVISAR RAFHVSPPLT SGPPEFERVF RAQVNCSEYF PLFLATLWVA GIFFHEGAAA LCGLFYLFAR LRYFQGYARS AQLRLTPLYA SARALWLLVA MAALGLLVHF LPGTLRTALF RWLQMLLPMA //