ID LC4S_MOUSE STANDARD; PRT; 150 AA. AC Q60860; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 20-AUG-2001 (Rel. 40, Last annotation update) DE Leukotriene C4 synthase (EC 2.5.1.37) (Leukotriene-C(4) synthase) DE (LTC4 synthase). GN LTC4S. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=98000279; PubMed=9342232; RA Penrose J.F., Baldasaro M.H., Webster M., Xu K., Austen K.F., RA Lam B.K.; RT "Molecular cloning of the gene for mouse leukotriene-C4 synthase."; RL Eur. J. Biochem. 248:807-813(1997). CC -!- FUNCTION: CATALYZES THE CONJUGATION OF LEUKOTRIENE A4 WITH REDUCED CC GLUTATHIONE TO FORM LEUKOTRIENE C4. CC -!- CATALYTIC ACTIVITY: LEUKOTRIENE A4 + GLUTATHIONE = LEUKOTRIENE C4 CC + H(2)O. CC -!- SUBUNIT: HOMODIMER (BY SIMILARITY). CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. CC -!- SIMILARITY: BELONGS TO THE MAPEG FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U27195; AAA75042.1; -. DR MGD; MGI:107498; Ltc4s. DR InterPro; IPR001129; MAPEG. DR Pfam; PF01124; MAPEG; 1. DR PROSITE; PS01297; FLAP_GST2_LTC4S; 1. KW Transferase; Transmembrane; Leukotriene biosynthesis. FT TRANSMEM 7 27 POTENTIAL. FT TRANSMEM 68 88 POTENTIAL. FT TRANSMEM 115 135 POTENTIAL. SQ SEQUENCE 150 AA; 16814 MW; 120ABC53892189C0 CRC64; MKDEVALLAT VTLVGVLLQA YFSLQVISAR RAFHVSPPLT SGPPEFERVF RAQVNCSEYF PLFLATLWVA GIFFHEGAAA LCGLFYLFAR LRYFQGYARS AQLRLTPLYA SARALWLLVA MAALGLLVHF LPGTLRTALF RWLQMLLPMA //