ID SPB6_MOUSE STANDARD; PRT; 378 AA. AC Q60854; DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 30-MAY-2006, entry version 52. DE Serpin B6 (Placental thrombin inhibitor) (Protease inhibitor 6) (PI- DE 6). GN Name=Serpinb6; Synonyms=Serpinb6a, Spi3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=BALB/c; RX MEDLINE=95332310; PubMed=7608171; DOI=10.1074/jbc.270.27.16089; RA Sun J., Rose J.B., Bird P.; RT "Gene structure, chromosomal localization, and expression of the RT murine homologue of human proteinase inhibitor 6 (PI-6) suggests RT divergence of PI-6 from the ovalbumin serpins."; RL J. Biol. Chem. 270:16089-16096(1995). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Mammary tumor; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Inhibits thrombin. CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U25844; AAA79684.1; -; mRNA. DR EMBL; BC006766; AAH06766.1; -; mRNA. DR EMBL; BC057950; AAH57950.1; -; mRNA. DR PIR; A57488; A57488. DR UniGene; Mm.252210; -. DR PDB; 1M37; Model; A=1-378. DR MEROPS; I04.030; -. DR Ensembl; ENSMUSG00000060147; Mus musculus. DR MGI; MGI:103123; Serpinb6a. DR InterPro; IPR000215; Prot_inh_serpin. DR PANTHER; PTHR11461; Prot_inh_serpin; 1. DR Pfam; PF00079; Serpin; 1. DR SMART; SM00093; SERPIN; 1. DR PROSITE; PS00284; SERPIN; 1. KW 3D-structure; Protease inhibitor; Serine protease inhibitor. FT CHAIN 1 378 Serpin B6. FT /FTId=PRO_0000094107. FT SITE 343 344 Reactive bond (By similarity). FT HELIX 2 21 FT STRAND 22 22 FT STRAND 24 25 FT STRAND 29 29 FT HELIX 31 44 FT STRAND 45 45 FT HELIX 47 57 FT HELIX 59 61 FT STRAND 62 62 FT TURN 63 64 FT HELIX 65 77 FT STRAND 79 80 FT STRAND 82 97 FT HELIX 101 111 FT STRAND 114 118 FT TURN 120 122 FT HELIX 124 139 FT TURN 140 141 FT STRAND 142 142 FT STRAND 144 144 FT STRAND 146 147 FT TURN 149 150 FT STRAND 151 152 FT TURN 154 155 FT STRAND 157 172 FT HELIX 176 178 FT STRAND 180 189 FT STRAND 191 208 FT TURN 209 212 FT STRAND 213 234 FT STRAND 236 238 FT STRAND 240 240 FT HELIX 241 244 FT HELIX 247 254 FT HELIX 256 258 FT STRAND 260 269 FT STRAND 271 273 FT STRAND 276 278 FT STRAND 280 280 FT HELIX 281 284 FT TURN 285 287 FT TURN 290 292 FT STRAND 293 293 FT TURN 294 296 FT STRAND 299 299 FT TURN 300 302 FT STRAND 303 304 FT STRAND 306 307 FT STRAND 310 310 FT STRAND 312 320 FT STRAND 322 336 FT STRAND 340 340 FT STRAND 343 343 FT STRAND 345 346 FT STRAND 348 348 FT STRAND 350 354 FT TURN 355 358 FT STRAND 359 363 FT STRAND 366 366 SQ SEQUENCE 378 AA; 42599 MW; 4B0F5E1A030BBDF6 CRC64; MDPLQEANGT FALNLLKILG EDSSKNVFLS PMSISSALAM VFMGAKGTTA SQMAQALALD KCSGNGGGDV HQGFQSLLTE VNKTGTQYLL RTANRLFGDK TCDLLASFKD SCLKFYEAEL EELDFQGATE ESRQHINTWV AKKTEDKIKE VLSPGTVNSD TSLVLVNAIY FKGNWEKQFN KEHTREMPFK VSKNEEKPVQ MMFKKSTFKM TYIGEIFTKI LLLPYVSSEL NMIIMLPDEH VELSTVEKEV TYEKFIEWTR LDKMDEEEVE VFLPKFKLEE NYNMNDALYK LGMTDAFGGR ADFSGMSSKQ GLFLSKVVHK AFVEVNEEGT EAAAATAGMM TVRCMRFTPR FCADHPFLFF IHHVKTNGIL FCGRFSSP //