ID SKIL_MOUSE Reviewed; 675 AA. AC Q60665; Q60702; Q78E90; Q80VK5; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 21-JUN-2005, sequence version 2. DT 08-MAR-2011, entry version 79. DE RecName: Full=Ski-like protein; DE AltName: Full=Ski-related oncogene; DE AltName: Full=Ski-related protein; GN Name=Skil; Synonyms=Skir, Sno; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). RC STRAIN=BALB/c; TISSUE=Brain, and Heart; RX MEDLINE=96431390; PubMed=8834472; RX DOI=10.1002/(SICI)1097-0177(199602)205:2<114::AID-AJA3>3.3.CO;2-N; RA Pelzer T.H., Lyons G.E., Kim S., Moreadith R.W.; RT "Cloning and characterization of the murine homolog of the sno proto- RT oncogene reveals a novel splice variant."; RL Dev. Dyn. 205:114-125(1996). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). RC STRAIN=C3H; TISSUE=Skeletal muscle; RX MEDLINE=97351167; PubMed=9207045; DOI=10.1093/nar/25.14.2930; RA Pearson-White S.H., Crittenden R.; RT "Proto-oncogene Sno expression, alternative isoforms and immediate RT early serum response."; RL Nucleic Acids Res. 25:2930-2937(1997). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC STRAIN=FVB/N; TISSUE=Mammary tumor; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: May have regulatory role in cell division or CC differentiation in response to extracellular signals (By CC similarity). CC -!- SUBUNIT: Interacts with SMAD2, SMAD3 and RNF111. Interacts with CC WWP1 (By similarity). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q60665-1; Sequence=Displayed; CC Name=2; CC IsoId=Q60665-2; Sequence=VSP_014265; CC -!- SIMILARITY: Belongs to the SKI family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U10530; AAB50266.1; -; mRNA. DR EMBL; U10532; AAB50267.1; -; mRNA. DR EMBL; U14655; AAB65849.1; -; mRNA. DR EMBL; BC049934; AAH49934.1; -; mRNA. DR IPI; IPI00119153; -. DR IPI; IPI00420977; -. DR RefSeq; NP_001034179.1; NM_001039090.1. DR RefSeq; NP_035516.2; NM_011386.2. DR UniGene; Mm.15406; -. DR ProteinModelPortal; Q60665; -. DR SMR; Q60665; 138-235, 258-353. DR STRING; Q60665; -. DR PhosphoSite; Q60665; -. DR PRIDE; Q60665; -. DR Ensembl; ENSMUST00000029194; ENSMUSP00000029194; ENSMUSG00000027660. DR Ensembl; ENSMUST00000118204; ENSMUSP00000112413; ENSMUSG00000027660. DR GeneID; 20482; -. DR KEGG; mmu:20482; -. DR UCSC; uc008ovu.1; mouse. DR UCSC; uc008ovv.1; mouse. DR CTD; 20482; -. DR MGI; MGI:106203; Skil. DR HOGENOM; HBG445660; -. DR HOVERGEN; HBG006599; -. DR InParanoid; Q60665; -. DR OMA; VCDELYI; -. DR NextBio; 298617; -. DR ArrayExpress; Q60665; -. DR Bgee; Q60665; -. DR CleanEx; MM_SKIL; -. DR Genevestigator; Q60665; -. DR GermOnline; ENSMUSG00000027660; Mus musculus. DR GO; GO:0003682; F:chromatin binding; IDA:MGI. DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro. DR GO; GO:0016564; F:transcription repressor activity; IDA:MGI. DR GO; GO:0001825; P:blastocyst formation; IMP:MGI. DR GO; GO:0007050; P:cell cycle arrest; IMP:MGI. DR GO; GO:0070306; P:lens fiber cell differentiation; IDA:MGI. DR GO; GO:0002260; P:lymphocyte homeostasis; IMP:MGI. DR GO; GO:0045596; P:negative regulation of cell differentiation; IDA:MGI. DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IMP:MGI. DR GO; GO:0042981; P:regulation of apoptosis; IMP:MGI. DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IGI:MGI. DR InterPro; IPR014890; c-SKI_SMAD-bd_dom. DR InterPro; IPR009061; DNA-bd_dom_put. DR InterPro; IPR010919; SAND_dom-like. DR InterPro; IPR003380; Transform_Ski. DR InterPro; IPR023216; Tscrpt_reg_SKI_SnoN. DR Gene3D; G3DSA:3.10.390.10; SAND; 1. DR Gene3D; G3DSA:3.10.260.20; Transform_Ski; 1. DR PANTHER; PTHR10005; Tscrpt_reg_SKI_SnoN; 1. DR Pfam; PF08782; c-SKI_SMAD_bind; 1. DR Pfam; PF02437; Ski_Sno; 1. DR SUPFAM; SSF46955; Putativ_DNA_bind; 1. DR SUPFAM; SSF63763; SAND_like; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Coiled coil; Phosphoprotein. FT CHAIN 1 675 Ski-like protein. FT /FTId=PRO_0000129388. FT COILED 526 669 Potential. FT MOD_RES 26 26 Phosphoserine (By similarity). FT VAR_SEQ 428 474 SKSTSKQSEKPHESSQHQKTVSYPDVSLEEQEKMDLKTSRE FT LYSCLD -> N (in isoform 2). FT /FTId=VSP_014265. FT CONFLICT 63 66 GEHA -> RAR (in Ref. 2; AAB65849). FT CONFLICT 130 130 P -> T (in Ref. 2; AAB65849). FT CONFLICT 150 150 S -> T (in Ref. 2; AAB65849). FT CONFLICT 205 205 L -> S (in Ref. 2; AAB65849). FT CONFLICT 229 229 A -> T (in Ref. 2; AAB65849). FT CONFLICT 302 303 MH -> ID (in Ref. 1; AAB50266/AAB50267). FT CONFLICT 542 542 R -> G (in Ref. 1; AAB50266/AAB50267). FT CONFLICT 618 618 A -> P (in Ref. 1; AAB50266/AAB50267). FT CONFLICT 622 622 A -> G (in Ref. 2; AAB65849). FT CONFLICT 638 639 RQ -> QR (in Ref. 2; AAB65849). SQ SEQUENCE 675 AA; 76359 MW; CE17BBC167693869 CRC64; MENLQSKFSL VQGSNKKLNG MEDDGSPPVK KMMTDIHANG KTLTKVKKEH LDDYGDASVE PDGEHAKRNR VSLPETLNLN PSLKHTLAQF HLSSQSSLGG PAAFSARYSQ ESMSPTVFLP LPSPQVLPGP LLIPSDSSTE LTQTLLEGES ISCFQVGGEK RLCLPQVLNS VLREFSLQQI NTVCDELYIY CSRCTSDQLH ILKVLGILPF NAPSCGLITL TDAQRLCNAL LRPRTFPQNG SILPAKSSLA QLKETGSAFE VEHECLGKCQ GLFAPQFYVQ PDAPCIQCLE CCGMFAPQTF VMHSHRSPDK RTCHWGFESA KWHCYLHVNQ KYLGTPEEKK LKIILEEMKE KFSMRNGKRI QSKTDTPSGM ELPSWYPVIK QEGDHVPQTH SFLHPSYYLY MCDKVVAPNV SLTSAASQSK EATKAETSKS TSKQSEKPHE SSQHQKTVSY PDVSLEEQEK MDLKTSRELY SCLDSSISNN STSRKKSESA VCSLVRGTSK RDSEDSSPLL VRDGEDDKGK IMEDVMRTYV RQQEKLNSIL QRKQQLQMEV EMLSSSKAMK ELTEEQQNLQ KELESLQSEH AQRMEEFYIE QRDLEKKLEQ VMQQKCTCDS TLEKDREAEY AAQLAELRQR LDHAEADRQE LQDELRQERE ARQKLEMMIK ELKLQIGKSS KPSKD //