ID PRCA_METJA STANDARD; PRT; 261 AA. AC Q60177; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 30-MAY-2000 (Rel. 39, Last annotation update) DE PROTEASOME ALPHA SUBUNIT (EC 3.4.99.46) (MULTICATALYTIC ENDOPEPTIDASE DE COMPLEX ALPHA SUBUNIT) (20S PROTEASOME ALPHA SUBUNIT). GN PSMA OR MJ0591. OS Methanococcus jannaschii. OC Archaea; Euryarchaeota; Methanococcales; Methanococcaceae; OC Methanococcus. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=JAL-1 / DSM 2661 / ATCC 43067; RX MEDLINE; 96337999. RA Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., RA Sutton G.G., Blake J.A., Fitzgerald L.M., Clayton R.A., Gocayne J.D., RA Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., RA Overbeek R., Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., RA Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., RA Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., RA Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., RA Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.; RT "Complete genome sequence of the methanogenic archaeon, Methanococcus RT jannaschii."; RL Science 273:1058-1073(1996). RN [2] RP CHARACTERIZATION. RX MEDLINE; 20158885. RA Wilson H.L., Ou M.S., Aldrich H.C., Maupin-Furlow J.; RT "Biochemical and physical properties of the Methanococcus jannaschii RT 20S proteasome and PAN, a homolog of the ATPase (Rpt) subunits of the RT eucaryal 26S proteasome."; RL J. Bacteriol. 182:1680-1692(2000). CC -!- FUNCTION: THE PROTEASOME IS A MULTICATALYTIC PROTEINASE COMPLEX CC WHICH IS CHARACTERIZED BY ITS ABILITY TO CLEAVE PEPTIDES WITH CC ARG, PHE, TYR, LEU, AND GLU ADJACENT TO THE LEAVING GROUP AT CC NEUTRAL OR SLIGHTLY BASIC PH. CC -!- PATHWAY: IS INVOLVED IN AN ATP/UBIQUITIN-DEPENDENT NON-LYSOSOMAL CC PROTEOLYTIC PATHWAY. CC -!- SUBUNIT: COMPOSED OF TWO SUBUNITS, ALPHA AND BETA. THE COMPLEX IS CC FORMED OF FOUR RINGS. THE TWO OUTER RINGS ARE EACH COMPOSED OF CC SEVEN ALPHA SUBUNITS. THE TWO INNER RINGS ARE EACH COMPOSED OF CC SEVEN BETA SUBUNITS (BY SIMILARITY). CC -!- SUBCELLULAR LOCATION: CYTOPLASMIC. CC -!- SIMILARITY: BELONGS TO PEPTIDASE FAMILY T1A; ALSO KNOWN AS THE CC PROTEASOME A-TYPE FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U67507; AAB98581.1; -. DR HSSP; P25156; 1PMA. DR TIGR; MJ0591; -. DR INTERPRO; IPR000426; -. DR INTERPRO; IPR001353; -. DR PFAM; PF00227; proteasome; 1. DR PROSITE; PS00388; PROTEASOME_A; 1. KW Proteasome; Hydrolase; Protease. SQ SEQUENCE 261 AA; 29320 MW; 93FC7DF277E01AD8 CRC64; MQMVPPSAYD RAITVFSPEG RLYQVEYARE AVRRGTTAIG IACKDGVVLA VDRRITSKLV KIRSIEKIFQ IDDHVAAATS GLVADARVLI DRARLEAQIY RLTYGEEISI EMLAKKICDI KQAYTQHGGV RPFGVSLLIA GIDKNEARLF ETDPSGALIE YKATAIGSGR PVVMELLEKE YRDDITLDEG LELAITALTK ANEDIKPENV DVCIITVKDA QFKKIPVEEI KKLIEKVKKK LNEENKKEEE NREETKEKQE E //