ID HIS4_LEGPH Reviewed; 239 AA. AC Q5ZW91; DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot. DT 23-NOV-2004, sequence version 1. DT 14-MAY-2014, entry version 67. DE RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; DE EC=5.3.1.16; DE AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; GN Name=hisA; OrderedLocusNames=lpg1195; OS Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / OS ATCC 33152 / DSM 7513). OC Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; OC Legionellaceae; Legionella. OX NCBI_TaxID=272624; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513; RX PubMed=15448271; DOI=10.1126/science.1099776; RA Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., RA Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., RA Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., RA Pampou S., Georghiou A., Chou I.-C., Iannuccilli W., Ulz M.E., RA Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G., RA Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J., RA Ju J., Kalachikov S., Shuman H.A., Russo J.J.; RT "The genomic sequence of the accidental pathogen Legionella RT pneumophila."; RL Science 305:1966-1968(2004). CC -!- CATALYTIC ACTIVITY: 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho- CC beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5- CC ((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5- CC phospho-beta-D-ribosyl)imidazole-4-carboxamide. CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L- CC histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the HisA/HisF family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE017354; AAU27280.1; -; Genomic_DNA. DR RefSeq; YP_007568514.1; NC_020521.1. DR RefSeq; YP_095227.1; NC_002942.5. DR ProteinModelPortal; Q5ZW91; -. DR STRING; 272624.lpg1195; -. DR DNASU; 3077897; -. DR EnsemblBacteria; AAU27280; AAU27280; lpg1195. DR GeneID; 14800663; -. DR GeneID; 3077897; -. DR KEGG; lpn:lpg1195; -. DR KEGG; lpu:LPE509_01971; -. DR PATRIC; 22329464; VBILegPne29832_1257. DR eggNOG; COG0106; -. DR HOGENOM; HOG000224614; -. DR KO; K01814; -. DR OMA; GWAEETD; -. DR OrthoDB; EOG6H1Q3W; -. DR BioCyc; LPNE272624:GHDI-1194-MONOMER; -. DR UniPathway; UPA00031; UER00009. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity; IEA:UniProtKB-HAMAP. DR GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-HAMAP. DR Gene3D; 3.20.20.70; -; 1. DR HAMAP; MF_01014; HisA; 1. DR InterPro; IPR013785; Aldolase_TIM. DR InterPro; IPR006062; His_biosynth. DR InterPro; IPR006063; HisA. DR InterPro; IPR023016; Isoase_HisA. DR InterPro; IPR011060; RibuloseP-bd_barrel. DR Pfam; PF00977; His_biosynth; 1. DR SUPFAM; SSF51366; SSF51366; 1. DR TIGRFAMs; TIGR00007; TIGR00007; 1. PE 3: Inferred from homology; KW Amino-acid biosynthesis; Complete proteome; Cytoplasm; KW Histidine biosynthesis; Isomerase. FT CHAIN 1 239 1-(5-phosphoribosyl)-5-[(5- FT phosphoribosylamino)methylideneamino] FT imidazole-4-carboxamide isomerase. FT /FTId=PRO_0000142015. FT ACT_SITE 8 8 Proton acceptor (By similarity). FT ACT_SITE 129 129 Proton donor (By similarity). SQ SEQUENCE 239 AA; 26377 MW; EC007CDC66444127 CRC64; MLVIPAIDLQ SGRCVRLKQG RFDQVTQFSV FPIERALHFA KLGAKRLHVV DLDGARSGKM QQLELICSMQ KTGIPIQAGG GIRSIEQALE CSNAGISQLV IGSLAITNPD LTIQIIEKIK PENIVLALDV RVDTKVPLLA INGWQNNSTS SLWEVVSYYE NYGIKNILCT DIACDGMMNG PNFDLYQQAV EYFPQIAWQA SGGVRHMQDI TTLNSLGISA VILGLMLYQD HMNLEELLC //