ID HIS4_LEGPH STANDARD; PRT; 239 AA. AC Q5ZW91; DT 01-FEB-2005 (Rel. 46, Created) DT 01-FEB-2005 (Rel. 46, Last sequence update) DT 01-MAY-2005 (Rel. 47, Last annotation update) DE 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] DE imidazole-4-carboxamide isomerase (EC 5.3.1.16) DE (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide DE isomerase). GN Name=hisA; OrderedLocusNames=lpg1195; OS Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / OS ATCC 33152). OC Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; OC Legionellaceae; Legionella. OX NCBI_TaxID=272624; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15448271; DOI=10.1126/science.1099776; RA Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., RA Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., RA Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., RA Pampou S., Georghiou A., Chou I.-C., Iannuccilli W., Ulz M.E., RA Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G., RA Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J., RA Ju J., Kalachikov S., Shuman H.A., Russo J.J.; RT "The genomic sequence of the accidental pathogen Legionella RT pneumophila."; RL Science 305:1966-1968(2004). CC -!- CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-5-((5- CC phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5- CC ((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5- CC phosphoribosyl)imidazole-4-carboxamide. CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L- CC histidine from PRPP: step 4. CC -!- SUBCELLULAR LOCATION: Cytoplasmic (By similarity). CC -!- SIMILARITY: Belongs to the hisA/hisF family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE017354; AAU27280.1; -. DR HAMAP; MF_01014; -; 1. DR InterPro; IPR003009; FMN_enzyme. DR InterPro; IPR006063; His4. DR InterPro; IPR006062; His_biosynth. DR Pfam; PF00977; His_biosynth; 1. DR TIGRFAMs; TIGR00007; His4; 1. KW Complete proteome; Histidine biosynthesis; Isomerase. FT ACT_SITE 8 8 Proton acceptor (By similarity). FT ACT_SITE 129 129 Proton donor (By similarity). SQ SEQUENCE 239 AA; 26377 MW; EC007CDC66444127 CRC64; MLVIPAIDLQ SGRCVRLKQG RFDQVTQFSV FPIERALHFA KLGAKRLHVV DLDGARSGKM QQLELICSMQ KTGIPIQAGG GIRSIEQALE CSNAGISQLV IGSLAITNPD LTIQIIEKIK PENIVLALDV RVDTKVPLLA INGWQNNSTS SLWEVVSYYE NYGIKNILCT DIACDGMMNG PNFDLYQQAV EYFPQIAWQA SGGVRHMQDI TTLNSLGISA VILGLMLYQD HMNLEELLC //