ID Q5ZW91 PRELIMINARY; PRT; 239 AA. AC Q5ZW91; DT 25-OCT-2004 (TrEMBLrel. 28, Created) DT 25-OCT-2004 (TrEMBLrel. 28, Last sequence update) DT 25-OCT-2004 (TrEMBLrel. 28, Last annotation update) DE 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] DE imidazole-4-carboxamide isomerase (EC 5.3.1.16) DE (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide DE isomerase). GN Name=hisA; ORFNames=lpg1195; OS Legionella pneumophila subsp. pneumophila str. Philadelphia 1. OC Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; OC Legionellaceae; Legionella. OX NCBI_TaxID=272624; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Philadelphia 1; RA Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., RA Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., RA Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., RA Pampou S., Georghiou A., Chou I.-C., Iannuccilli W., Ulz M.E., RA Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G., RA Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J., RA Ju J., Kalachikov S., Shuman H.A., Russo J.J.; RT "The Genomic Sequence of the Accidental Pathogen Legionella RT pneumophila."; RL Science 305:1966-1968(2004). CC -!- CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-5-((5- CC phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5- CC ((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5- CC phosphoribosyl)imidazole-4-carboxamide. CC -!- PATHWAY: Histidine biosynthesis; fourth step. CC -!- SUBCELLULAR LOCATION: Cytoplasmic (By similarity). CC -!- SIMILARITY: Belongs to the hisA / hisF family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE017354; AAU27280.1; -. DR InterPro; IPR003009; FMN_enzyme. DR InterPro; IPR006063; His4. DR InterPro; IPR006062; His_biosynth. DR Pfam; PF00977; His_biosynth; 1. DR TIGRFAMs; TIGR00007; His4; 1. KW Histidine biosynthesis; Isomerase. SQ SEQUENCE 239 AA; 26376 MW; EC007CDC66444127 CRC64; MLVIPAIDLQ SGRCVRLKQG RFDQVTQFSV FPIERALHFA KLGAKRLHVV DLDGARSGKM QQLELICSMQ KTGIPIQAGG GIRSIEQALE CSNAGISQLV IGSLAITNPD LTIQIIEKIK PENIVLALDV RVDTKVPLLA INGWQNNSTS SLWEVVSYYE NYGIKNILCT DIACDGMMNG PNFDLYQQAV EYFPQIAWQA SGGVRHMQDI TTLNSLGISA VILGLMLYQD HMNLEELLC //