ID Q5ZUV9_LEGPH Unreviewed; 502 AA. AC Q5ZUV9; DT 23-NOV-2004, integrated into UniProtKB/TrEMBL. DT 23-NOV-2004, sequence version 1. DT 20-DEC-2017, entry version 65. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:AAU27763.1}; GN OrderedLocusNames=lpg1683 {ECO:0000313|EMBL:AAU27763.1}; OS Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / OS ATCC 33152 / DSM 7513). OC Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; OC Legionellaceae; Legionella. OX NCBI_TaxID=272624 {ECO:0000313|EMBL:AAU27763.1, ECO:0000313|Proteomes:UP000000609}; RN [1] {ECO:0000313|EMBL:AAU27763.1, ECO:0000313|Proteomes:UP000000609} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513 RC {ECO:0000313|Proteomes:UP000000609}; RX PubMed=15448271; DOI=10.1126/science.1099776; RA Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., RA Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., RA Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., RA Pampou S., Georghiou A., Chou I.C., Iannuccilli W., Ulz M.E., RA Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G., RA Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J., RA Ju J., Kalachikov S., Shuman H.A., Russo J.J.; RT "The genomic sequence of the accidental pathogen Legionella RT pneumophila."; RL Science 305:1966-1968(2004). RN [2] {ECO:0000213|PDB:5CQC} RP X-RAY CRYSTALLOGRAPHY (2.98 ANGSTROMS) OF 10-458. RX PubMed=26343456; DOI=10.1016/j.devcel.2015.08.010; RA Horenkamp F.A., Kauffman K.J., Kohler L.J., Sherwood R.K., RA Krueger K.P., Shteyn V., Roy C.R., Melia T.J., Reinisch K.M.; RT "The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome RT via PI3P- and Curvature-Sensing Motifs."; RL Dev. Cell 34:569-576(2015). RN [3] {ECO:0000213|PDB:5HZY, ECO:0000213|PDB:5IO3, ECO:0000213|PDB:5IZV} RP X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 49-502. RX PubMed=27791457; DOI=10.1080/15548627.2016.1243199; RA Kwon D.H., Kim S., Jung Y.O., Roh K.H., Kim L., Kim B.W., Hong S.B., RA Lee I.Y., Song J.H., Lee W.C., Choi E.J., Hwang K.Y., Song H.K.; RT "The 1:2 complex between RavZ and LC3 reveals a mechanism for RT deconjugation of LC3 on the phagophore membrane."; RL Autophagy 13:70-81(2017). RN [4] {ECO:0000213|PDB:5XAD} RP X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS) OF 12-34. RX PubMed=28668392; DOI=10.1016/j.bbrc.2017.06.173; RA Kwon D.H., Kim L., Kim B.W., Kim J.H., Roh K.H., Choi E.J., Song H.K.; RT "A novel conformation of the LC3-interacting region motif revealed by RT the structure of a complex between LC3B and RavZ."; RL Biochem. Biophys. Res. Commun. 490:1093-1099(2017). RN [5] {ECO:0000213|PDB:5MS2, ECO:0000213|PDB:5MS5, ECO:0000213|PDB:5MS7} RP X-RAY CRYSTALLOGRAPHY (1.53 ANGSTROMS) OF 24-36 AND 39-46. RX PubMed=28395732; DOI=10.7554/eLife.23905; RA Yang A., Pantoom S., Wu Y.W.; RT "Elucidation of the anti-autophagy mechanism of the Legionella RT effector RavZ using semisynthetic LC3 proteins."; RL Elife 6:0-0(2017). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE017354; AAU27763.1; -; Genomic_DNA. DR RefSeq; WP_010947410.1; NC_002942.5. DR RefSeq; YP_095710.1; NC_002942.5. DR PDB; 5CQC; X-ray; 2.98 A; A=10-458. DR PDB; 5HZY; X-ray; 2.55 A; A=49-502. DR PDB; 5IO3; X-ray; 2.74 A; A=1-502. DR PDB; 5IZV; X-ray; 2.81 A; A/B=1-502. DR PDB; 5MS2; X-ray; 2.47 A; A=1-431. DR PDB; 5MS5; X-ray; 1.53 A; A/B=24-36, A/B=39-39. DR PDB; 5MS7; X-ray; 2.80 A; A=20-502. DR PDB; 5MS8; X-ray; 2.85 A; A=1-487. DR PDB; 5XAD; X-ray; 1.88 A; C/D=12-34. DR PDBsum; 5CQC; -. DR PDBsum; 5HZY; -. DR PDBsum; 5IO3; -. DR PDBsum; 5IZV; -. DR PDBsum; 5MS2; -. DR PDBsum; 5MS5; -. DR PDBsum; 5MS7; -. DR PDBsum; 5MS8; -. DR SMR; Q5ZUV9; -. DR STRING; 272624.lpg1683; -. DR PaxDb; Q5ZUV9; -. DR EnsemblBacteria; AAU27763; AAU27763; lpg1683. DR GeneID; 19833248; -. DR KEGG; lpn:lpg1683; -. DR PATRIC; fig|272624.6.peg.1764; -. DR HOGENOM; HOG000278269; -. DR OMA; IEIERTM; -. DR Proteomes; UP000000609; Chromosome. PE 1: Evidence at protein level; KW 3D-structure {ECO:0000213|PDB:5CQC, ECO:0000213|PDB:5HZY, KW ECO:0000213|PDB:5IO3, ECO:0000213|PDB:5IZV}; KW Complete proteome {ECO:0000313|Proteomes:UP000000609}; KW Reference proteome {ECO:0000313|Proteomes:UP000000609}. SQ SEQUENCE 502 AA; 56242 MW; 698B442E58770745 CRC64; MKGKLTGKDK LIVDEFEELG EQESDIDEFD LLEGDEKLPG DSELDKTTSI YPPETSWEVN KGMNSSRLHK LYSLFFDKSS AFYLGDDVSV LEDKPLTGAY GFQSKKNDQQ IFLFRPDSDY VAGYHVDAKS DAGWVNDKLD RRLSEISEFC SKATQPATFI LPFVEMPTDI TKGVQHQVLL TISYDPKSKQ LTPTVYDSIG RDTYSESLSS YFKGKYRTTC DEILTQSIEK AIKSTDFTLG KFTRAAYNHQ NRLTEGNCGS YTFRTIKEVI SSSAQGTEVK IPGSGYITSN SYLTSQHVQD IESCIKYRNL GVVDIESALT EGKTLPVQLS EFIVALEDYG KLRSQQSEKS MLNFIGYSKT AKLTAVELLI GILNDIKGKN EISESQYDKL VKEVDCLMDS SLGKLVQFHL KNLGAESLQK LVLPCVKFDD TIDDFVTIEK DELFDVPDIT GEELASKKGI EQGALDKEAL LKQKQIKTDL LDLREEDKTG LKKPLHGGIK VK //