ID Q5ZU83_LEGPH Unreviewed; 930 AA. AC Q5ZU83; DT 23-NOV-2004, integrated into UniProtKB/TrEMBL. DT 23-NOV-2004, sequence version 1. DT 03-AUG-2022, entry version 86. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:AAU27994.1}; GN OrderedLocusNames=lpg1924 {ECO:0000313|EMBL:AAU27994.1}; OS Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC OS 33152 / DSM 7513). OC Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; OC Legionellaceae; Legionella. OX NCBI_TaxID=272624 {ECO:0000313|EMBL:AAU27994.1, ECO:0000313|Proteomes:UP000000609}; RN [1] {ECO:0000313|EMBL:AAU27994.1, ECO:0000313|Proteomes:UP000000609} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513 RC {ECO:0000313|Proteomes:UP000000609}; RX PubMed=15448271; DOI=10.1126/science.1099776; RA Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G., RA Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V., RA Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A., RA Chou I.C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A., RA Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A., RA Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A., RA Russo J.J.; RT "The genomic sequence of the accidental pathogen Legionella pneumophila."; RL Science 305:1966-1968(2004). RN [2] {ECO:0007829|PDB:6MCP, ECO:0007829|PDB:6MCQ} RP X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 11-530. RX PubMed=32513747; DOI=10.1073/pnas.2000497117; RA Lee P.C., Beyrakhova K., Xu C., Boniecki M.T., Lee M.H., Onu C.J., RA Grishin A.M., Machner M.P., Cygler M.; RT "The Legionella kinase LegK7 exploits the Hippo pathway scaffold RT protein MOB1A for allostery and substrate phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 117:14433-14443(2020). RN [3] {ECO:0007829|PDB:7BYK} RP X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 1-471. RX PubMed=33309852; DOI=10.1016/j.jmb.2020.166746; RA Park S.C., Cho S.Y., Kim T.H., Ko K.Y., Song W.S., Kang S.G., Lee G.S., RA Yoon S.I.; RT "Activation of the Legionella pneumophila LegK7 Effector Kinase by the Host RT MOB1 Protein."; RL J. Mol. Biol. 433:166746-166746(2021). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE017354; AAU27994.1; -; Genomic_DNA. DR RefSeq; WP_010947641.1; NC_002942.5. DR RefSeq; YP_095941.1; NC_002942.5. DR PDB; 6MCP; X-ray; 2.50 A; A/C=11-530. DR PDB; 6MCQ; X-ray; 2.57 A; A/C=11-530. DR PDB; 7BYK; X-ray; 2.65 A; A/B=1-471. DR PDBsum; 6MCP; -. DR PDBsum; 6MCQ; -. DR SMR; Q5ZU83; -. DR STRING; 272624.lpg1924; -. DR PaxDb; Q5ZU83; -. DR PRIDE; Q5ZU83; -. DR EnsemblBacteria; AAU27994; AAU27994; lpg1924. DR GeneID; 66491056; -. DR KEGG; lpn:lpg1924; -. DR PATRIC; fig|272624.6.peg.2009; -. DR eggNOG; ENOG5031QIG; Bacteria. DR HOGENOM; CLU_336432_0_0_6; -. DR OMA; WINDAEE; -. DR Proteomes; UP000000609; Chromosome. DR InterPro; IPR011009; Kinase-like_dom_sf. DR SUPFAM; SSF56112; SSF56112; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:6MCP, ECO:0007829|PDB:6MCQ}; KW Reference proteome {ECO:0000313|Proteomes:UP000000609}. FT REGION 765..784 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 799..930 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 834..876 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 900..919 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 930 AA; 107369 MW; 4168F4903E58F3C2 CRC64; MPLNLPPKSS KNTMPLVIAY NNAPEDDKIQ KLFYLQKINY LLNKTQLNDD LFDWINDAEE GGWLNELAKF SINPNASFFL KGMQFAKAIT EEIKNKPEIN SSEVNIYHLM QERDQLLKEV EFEKCATRYA EINFLLNELA LNDKKTKEIV ERQTEILRLV APKIKAIKGE SIDNLPVIPS YKTKELGNHV NNFNFKFTMS GWEAPFVFRV EDRHELGKEQ ELHSYGVSKY FIEDYSVFMM RFKAEDGSTV YKPVILSQFA NQNNLEEIAK QLKDGSPKNI APRIGYYFVQ LTDFCLKLIE THNYHPDIKL NNFLVHNNRV LVSDRKTFTT NDNPLASEIL TSPLFAPDEF LKCLLFNKEG DPVGYNRNAL WKRMNMPQFM AYQLGMALKQ FLILTQLDEL PDDFRNPDHS AVSHFKTPSR QIINLSLLVQ ELTRLDPDKR MTIKQFQTLL NFKNLPPDAF YQKVEEVFPS SQLGIAEDIE ALNKVLNSDL KGEALLKQAN PVFTKLSKYD PKETRLTRLA EKLAIRCFNN VSKPYFQKLS GLIESALEKD VNEIRQLLNP QSNSERLLQK ASPIFMKLFE RQPEVPQLTD LAKQLAAQCF DESSKNYFTR QLPLLIEEEL LNQDWEQAPW YRKALHWLTF GYFRVDNVTE ISSLKIPEHT KGKEFQIYFW QLLFLPSEEI KNMFTSKDSQ ISEFLLGYIE KEREKRETET PSVQIPVDLK GEEFQIHFPQ LEFLPSKDFE SIGEKEGEHL ECFIFANLQE ILSHNNSDSS EKNSTSEPSD SESEIHLNAG NVDTIIIANE PNPTDAKPQK KDNDGAKQNN PAKASSPEGI VSTPEVEEHP KKKITDDAPK PKTKRSVHFF DEAKKSKPKE KENASPAVDE TPPAKRKNVC RIDSVRSTLF RGDGSHRQKI KEQRPRLSEI AWEPPKPNLQ //