ID Q5ZU74_LEGPH Unreviewed; 436 AA. AC Q5ZU74; DT 23-NOV-2004, integrated into UniProtKB/TrEMBL. DT 23-NOV-2004, sequence version 1. DT 27-MAR-2024, entry version 71. DE RecName: Full=Type II toxin-antitoxin system HipA family toxin {ECO:0008006|Google:ProtNLM}; GN OrderedLocusNames=lpg1934 {ECO:0000313|EMBL:AAU28003.1}; OS Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC OS 33152 / DSM 7513). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales; OC Legionellaceae; Legionella. OX NCBI_TaxID=272624 {ECO:0000313|EMBL:AAU28003.1, ECO:0000313|Proteomes:UP000000609}; RN [1] {ECO:0000313|EMBL:AAU28003.1, ECO:0000313|Proteomes:UP000000609} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513 RC {ECO:0000313|Proteomes:UP000000609}; RX PubMed=15448271; DOI=10.1126/science.1099776; RA Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G., RA Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V., RA Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A., RA Chou I.C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A., RA Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A., RA Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A., RA Russo J.J.; RT "The genomic sequence of the accidental pathogen Legionella pneumophila."; RL Science 305:1966-1968(2004). CC -!- SIMILARITY: Belongs to the HipA Ser/Thr kinase family. CC {ECO:0000256|ARBA:ARBA00010164}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE017354; AAU28003.1; -; Genomic_DNA. DR RefSeq; YP_095950.1; NC_002942.5. DR AlphaFoldDB; Q5ZU74; -. DR STRING; 272624.lpg1934; -. DR PaxDb; 272624-lpg1934; -. DR KEGG; lpn:lpg1934; -. DR PATRIC; fig|272624.6.peg.2019; -. DR eggNOG; COG3550; Bacteria. DR HOGENOM; CLU_030167_1_0_6; -. DR OrthoDB; 9805913at2; -. DR Proteomes; UP000000609; Chromosome. DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW. DR Gene3D; 1.10.1070.20; -; 1. DR InterPro; IPR012893; HipA-like_C. DR InterPro; IPR017508; HipA_N1. DR NCBIfam; TIGR03071; couple_hipA; 1. DR PANTHER; PTHR37419; SERINE/THREONINE-PROTEIN KINASE TOXIN HIPA; 1. DR PANTHER; PTHR37419:SF1; SERINE_THREONINE-PROTEIN KINASE TOXIN HIPA; 1. DR Pfam; PF13657; Couple_hipA; 1. DR Pfam; PF07804; HipA_C; 1. PE 3: Inferred from homology; KW Reference proteome {ECO:0000313|Proteomes:UP000000609}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 13..107 FT /note="HipA N-terminal subdomain 1" FT /evidence="ECO:0000259|Pfam:PF13657" FT DOMAIN 149..388 FT /note="HipA-like C-terminal" FT /evidence="ECO:0000259|Pfam:PF07804" SQ SEQUENCE 436 AA; 49859 MW; 959D341E78858D39 CRC64; MVRMKMIGDK SVLDVYLGES QIANITLIDD QLYWSYHESW QQTGYAISPH LPMHEDIPPL NVQRFLRNLL PEGNPLEVLV NVFHLSKYNT FGLIQALGLD TPGSLVILPS NQAIPKHANF RLVTHEELED RLNHCDSYNL IVWDGKPRLS VAGVQDKINV VLNKEGQLGF GEGSLCSTHI LKFETQKLSY LVLNEFLSMW LAKCCELNVA NVQMKRFGQN PALLVERFDR KLITTNIVKR RHLIDGCQAM NLPPEFKYEQ NFGNNRDVAH IRDGVSLPKL FDFANQCINP AKTKQQILDW VLFNVLIFNC DAHGKNISFF VGVNGISLAP FYDLVNIKMY PEFEHALAMA LGDEFDGDNI NAYQLADFAD TCRLPRSLVA KHLKYLIGKL TTALQEETQF NLVGNEEDYF KKYQEIVMKR CEHLLKQNDQ ITSIKL //