ID Q5YF88_DANRE Unreviewed; 210 AA. AC Q5YF88; DT 23-NOV-2004, integrated into UniProtKB/TrEMBL. DT 23-NOV-2004, sequence version 1. DT 08-NOV-2023, entry version 87. DE SubName: Full=Activation-induced cytidine deaminase {ECO:0000313|EMBL:AAS99176.1}; DE SubName: Full=Single-stranded DNA cytosine deaminase {ECO:0000313|RefSeq:NP_001008403.1}; DE EC=3.5.4.38 {ECO:0000313|RefSeq:NP_001008403.1}; GN OrderedLocusNames=aicda {ECO:0000313|RefSeq:NP_001008403.1, GN ECO:0000313|ZFIN:ZDB-GENE-041122-2}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAS99176.1}; RN [1] {ECO:0000313|EMBL:AAS99176.1, ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=15325524; DOI=10.1016/j.dci.2004.05.005; RA Zhao Y., Pan-Hammarstrom Q., Zhao Z., Hammarstrom L.; RT "Identification of the activation-induced cytidine deaminase gene from RT zebrafish: an evolutionary analysis."; RL Dev. Comp. Immunol. 29:61-71(2005). RN [2] {ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16157688; RA Barreto V.M., Pan-Hammarstrom Q., Zhao Y., Hammarstrom L., Misulovin Z., RA Nussenzweig M.C.; RT "AID from bony fish catalyzes class switch recombination."; RL J. Exp. Med. 202:733-738(2005). RN [3] {ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16291656; DOI=10.1093/intimm/dxh347; RA Wakae K., Magor B.G., Saunders H., Nagaoka H., Kawamura A., Kinoshita K., RA Honjo T., Muramatsu M.; RT "Evolution of class switch recombination function in fish activation- RT induced cytidine deaminase, AID."; RL Int. Immunol. 18:41-47(2006). RN [4] {ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=19109892; RA Rai K., Huggins I.J., James S.R., Karpf A.R., Jones D.A., Cairns B.R.; RT "DNA demethylation in zebrafish involves the coupling of a deaminase, a RT glycosylase, and gadd45."; RL Cell 135:1201-1212(2008). RN [5] {ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=18951095; RA Basu U., Wang Y., Alt F.W.; RT "Evolution of phosphorylation-dependent regulation of activation-induced RT cytidine deaminase."; RL Mol. Cell 32:285-291(2008). RN [6] {ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24161771; DOI=10.1016/j.fsi.2013.09.035; RA Villota-Herdoiza D., Pila E.A., Quiniou S., Waldbieser G.C., Magor B.G.; RT "Transcriptional regulation of teleost Aicda genes. Part 1 - suppressors of RT promiscuous promoters."; RL Fish Shellfish Immunol. 35:1981-1987(2013). RN [7] {ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [8] {ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24463314; RA Wei N., Pang W., Wang Y., Xiong Y., Xu R., Wu W., Zhao C., Yang G.; RT "Knockdown of PU.1 mRNA and AS lncRNA regulates expression of immune- RT related genes in zebrafish Danio rerio."; RL Dev. Comp. Immunol. 44:315-319(2014). RN [9] {ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24396069; RA Ge L., Zhang R.P., Wan F., Guo D.Y., Wang P., Xiang L.X., Shao J.Z.; RT "TET2 plays an essential role in erythropoiesis by regulating lineage- RT specific genes via DNA oxidative demethylation in a zebrafish model."; RL Mol. Cell. Biol. 34:989-1002(2014). RN [10] {ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25536520; RA Shimoda N., Hirose K., Kaneto R., Izawa T., Yokoi H., Hashimoto N., RA Kikuchi Y.; RT "No evidence for AID/MBD4-coupled DNA demethylation in zebrafish embryos."; RL PLoS ONE 9:e114816-e114816(2014). RN [11] {ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27504894; RA Choi J.S., Kim R.O., Yoon S., Kim W.K.; RT "Developmental Toxicity of Zinc Oxide Nanoparticles to Zebrafish (Danio RT rerio): A Transcriptomic Analysis."; RL PLoS ONE 11:e0160763-e0160763(2016). RN [12] {ECO:0000313|RefSeq:NP_001008403.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (JUL-2023) to UniProtKB. CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|ARBA:ARBA00001947}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY528720; AAS99176.1; -; mRNA. DR RefSeq; NP_001008403.1; NM_001008403.1. DR SMR; Q5YF88; -. DR GeneID; 493784; -. DR KEGG; dre:493784; -. DR CTD; 57379; -. DR ZFIN; ZDB-GENE-041122-2; aicda. DR OrthoDB; 5355962at2759; -. DR PhylomeDB; Q5YF88; -. DR Proteomes; UP000000437; Chromosome 16. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; ISS:ZFIN. DR GO; GO:0004126; F:cytidine deaminase activity; IDA:ZFIN. DR GO; GO:0003723; F:RNA binding; IBA:GO_Central. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0016554; P:cytidine to uridine editing; IBA:GO_Central. DR GO; GO:0080111; P:DNA demethylation; IBA:GO_Central. DR GO; GO:0016444; P:somatic cell DNA recombination; IDA:ZFIN. DR CDD; cd01283; cytidine_deaminase; 1. DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1. DR InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd. DR InterPro; IPR002125; CMP_dCMP_dom. DR InterPro; IPR016193; Cytidine_deaminase-like. DR PANTHER; PTHR13857; MRNA EDITING ENZYME; 1. DR PANTHER; PTHR13857:SF10; SINGLE-STRANDED DNA CYTOSINE DEAMINASE; 1. DR Pfam; PF18772; APOBEC2; 1. DR SUPFAM; SSF53927; Cytidine deaminase-like; 1. DR PROSITE; PS00903; CYT_DCMP_DEAMINASES_1; 1. DR PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1. PE 2: Evidence at transcript level; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}. FT DOMAIN 1..142 FT /note="CMP/dCMP-type deaminase" FT /evidence="ECO:0000259|PROSITE:PS51747" SQ SEQUENCE 210 AA; 24622 MW; F0C95934E6AE901B CRC64; MICKLDSVLM TQKKFIFHYK NVRWARGRHE TYLCFVVKRR IGPDSLSFDF GHLRNRSGCH VELLFLRHLG ALCPGLSASS VDGARLCYSV TWFCSWSPCS KCAQQLAHFL SQTPNLRLRI FVSRLYFCDE EDSVEREGLR HLKRAGVQIS VMTYKDFFYC WQTFVARRER SFKAWDGLHE NSVRLVRKLN RILQPCETED LRDVFALLGL //