ID Q5YF88_DANRE Unreviewed; 210 AA. AC Q5YF88; DT 23-NOV-2004, integrated into UniProtKB/TrEMBL. DT 23-NOV-2004, sequence version 1. DT 03-MAY-2023, entry version 84. DE SubName: Full=Activation-induced cytidine deaminase {ECO:0000313|EMBL:AAS99176.1}; DE SubName: Full=Single-stranded DNA cytosine deaminase {ECO:0000313|RefSeq:NP_001008403.1}; DE EC=3.5.4.38 {ECO:0000313|RefSeq:NP_001008403.1}; GN OrderedLocusNames=aicda {ECO:0000313|RefSeq:NP_001008403.1, GN ECO:0000313|ZFIN:ZDB-GENE-041122-2}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAS99176.1}; RN [1] {ECO:0000313|EMBL:AAS99176.1, ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=15325524; DOI=10.1016/j.dci.2004.05.005; RA Zhao Y., Pan-Hammarstrom Q., Zhao Z., Hammarstrom L.; RT "Identification of the activation-induced cytidine deaminase gene from RT zebrafish: an evolutionary analysis."; RL Dev. Comp. Immunol. 29:61-71(2005). RN [2] {ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16157688; RA Barreto V.M., Pan-Hammarstrom Q., Zhao Y., Hammarstrom L., Misulovin Z., RA Nussenzweig M.C.; RT "AID from bony fish catalyzes class switch recombination."; RL J. Exp. Med. 202:733-738(2005). RN [3] {ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16291656; DOI=10.1093/intimm/dxh347; RA Wakae K., Magor B.G., Saunders H., Nagaoka H., Kawamura A., Kinoshita K., RA Honjo T., Muramatsu M.; RT "Evolution of class switch recombination function in fish activation- RT induced cytidine deaminase, AID."; RL Int. Immunol. 18:41-47(2006). RN [4] {ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=19109892; RA Rai K., Huggins I.J., James S.R., Karpf A.R., Jones D.A., Cairns B.R.; RT "DNA demethylation in zebrafish involves the coupling of a deaminase, a RT glycosylase, and gadd45."; RL Cell 135:1201-1212(2008). RN [5] {ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=18951095; RA Basu U., Wang Y., Alt F.W.; RT "Evolution of phosphorylation-dependent regulation of activation-induced RT cytidine deaminase."; RL Mol. Cell 32:285-291(2008). RN [6] {ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24161771; DOI=10.1016/j.fsi.2013.09.035; RA Villota-Herdoiza D., Pila E.A., Quiniou S., Waldbieser G.C., Magor B.G.; RT "Transcriptional regulation of teleost Aicda genes. Part 1 - suppressors of RT promiscuous promoters."; RL Fish Shellfish Immunol. 35:1981-1987(2013). RN [7] {ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24463314; RA Wei N., Pang W., Wang Y., Xiong Y., Xu R., Wu W., Zhao C., Yang G.; RT "Knockdown of PU.1 mRNA and AS lncRNA regulates expression of immune- RT related genes in zebrafish Danio rerio."; RL Dev. Comp. Immunol. 44:315-319(2014). RN [8] {ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24396069; RA Ge L., Zhang R.P., Wan F., Guo D.Y., Wang P., Xiang L.X., Shao J.Z.; RT "TET2 plays an essential role in erythropoiesis by regulating lineage- RT specific genes via DNA oxidative demethylation in a zebrafish model."; RL Mol. Cell. Biol. 34:989-1002(2014). RN [9] {ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25536520; RA Shimoda N., Hirose K., Kaneto R., Izawa T., Yokoi H., Hashimoto N., RA Kikuchi Y.; RT "No evidence for AID/MBD4-coupled DNA demethylation in zebrafish embryos."; RL PLoS ONE 9:E114816-E114816(2014). RN [10] {ECO:0000313|RefSeq:NP_001008403.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27504894; RA Choi J.S., Kim R.O., Yoon S., Kim W.K.; RT "Developmental Toxicity of Zinc Oxide Nanoparticles to Zebrafish (Danio RT rerio): A Transcriptomic Analysis."; RL PLoS ONE 11:e0160763-e0160763(2016). RN [11] {ECO:0000313|RefSeq:NP_001008403.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (JAN-2023) to UniProtKB. CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|ARBA:ARBA00001947}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY528720; AAS99176.1; -; mRNA. DR RefSeq; NP_001008403.1; NM_001008403.1. DR GeneID; 493784; -. DR KEGG; dre:493784; -. DR CTD; 57379; -. DR ZFIN; ZDB-GENE-041122-2; aicda. DR OrthoDB; 5355962at2759; -. DR PhylomeDB; Q5YF88; -. DR Proteomes; UP000000437; Chromosome 16. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; ISS:ZFIN. DR GO; GO:0004126; F:cytidine deaminase activity; IDA:ZFIN. DR GO; GO:0003723; F:RNA binding; IBA:GO_Central. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0016554; P:cytidine to uridine editing; IBA:GO_Central. DR GO; GO:0080111; P:DNA demethylation; IBA:GO_Central. DR GO; GO:0016444; P:somatic cell DNA recombination; IDA:ZFIN. DR CDD; cd01283; cytidine_deaminase; 1. DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1. DR InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd. DR InterPro; IPR002125; CMP_dCMP_dom. DR InterPro; IPR016193; Cytidine_deaminase-like. DR PANTHER; PTHR13857; MRNA EDITING ENZYME; 1. DR PANTHER; PTHR13857:SF10; SINGLE-STRANDED DNA CYTOSINE DEAMINASE; 1. DR Pfam; PF18772; APOBEC2; 1. DR SUPFAM; SSF53927; Cytidine deaminase-like; 1. DR PROSITE; PS00903; CYT_DCMP_DEAMINASES_1; 1. DR PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1. PE 2: Evidence at transcript level; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}. FT DOMAIN 1..142 FT /note="CMP/dCMP-type deaminase" FT /evidence="ECO:0000259|PROSITE:PS51747" SQ SEQUENCE 210 AA; 24622 MW; F0C95934E6AE901B CRC64; MICKLDSVLM TQKKFIFHYK NVRWARGRHE TYLCFVVKRR IGPDSLSFDF GHLRNRSGCH VELLFLRHLG ALCPGLSASS VDGARLCYSV TWFCSWSPCS KCAQQLAHFL SQTPNLRLRI FVSRLYFCDE EDSVEREGLR HLKRAGVQIS VMTYKDFFYC WQTFVARRER SFKAWDGLHE NSVRLVRKLN RILQPCETED LRDVFALLGL //