ID Q5Y191_HUMAN Unreviewed; 306 AA. AC Q5Y191; DT 23-NOV-2004, integrated into UniProtKB/TrEMBL. DT 23-NOV-2004, sequence version 1. DT 18-MAY-2010, entry version 44. DE SubName: Full=Aurora-C; GN Name=AURKC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Testis; RX PubMed=15316025; DOI=10.1074/jbc.M403029200; RA Li X., Sakashita G., Matsuzaki H., Sugimoto K., Kimura K., Hanaoka F., RA Taniguchi H., Furukawa K., Urano T.; RT "Direct association with inner centromere protein (INCENP) activates RT the novel chromosomal passenger protein, Aurora-C."; RL J. Biol. Chem. 279:47201-47211(2004). CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY714054; AAU04399.1; -; mRNA. DR IPI; IPI00099756; -. DR UniGene; Hs.98338; -. DR SMR; Q5Y191; 33-300. DR STRING; Q5Y191; -. DR Ensembl; ENST00000302804; ENSP00000302898; ENSG00000105146; Homo sapiens. DR HGNC; HGNC:11391; AURKC. DR HOVERGEN; HBG108519; -. DR ArrayExpress; Q5Y191; -. DR Bgee; Q5Y191; -. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. DR GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro. DR InterPro; IPR020636; Ca/CaM-dep_prot_kinase-like. DR InterPro; IPR011009; Kinase-like_dom. DR InterPro; IPR000719; Prot_kinase_cat_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR017442; Se/Thr_prot_kinase-like_dom. DR InterPro; IPR008271; Ser/Thr_prot_kinase_AS. DR InterPro; IPR002290; Ser/Thr_prot_kinase_dom. DR InterPro; IPR020663; Spindle_assmbl_checkpoint_kin. DR PANTHER; PTHR22982; Ca/CaM-dep_prot_kinase-like; 1. DR PANTHER; PTHR22982:SF49; Spindle_assmbl_checkpoint_kin; 1. DR Pfam; PF00069; Pkinase; 1. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; Kinase_like; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 2: Evidence at transcript level; KW ATP-binding; Nucleotide-binding; Serine/threonine-protein kinase. SQ SEQUENCE 306 AA; 35322 MW; 869FC07D176B45CE CRC64; MSSPRAVVQL GKAQPAGEES NQTAQQPSSP AMRRLTVDDF EIGRPLGKGK FGNVYLARLK ESHFIVALKV LFKSQIEKEG LEHQLRREIE IQAHLQHPNI LRLYNYFHDA RRVYLILEYA PRGELYKELQ KSEKLDEQRT ATIIEELADA LTYCHDKKVI HRDIKPENLL LGFRGEVKIA DFGWSVHTPS LRRKTMCGTL DYLPPEMIEG RTYDEKVDLW CIGVLCYELL VGYPPFESAS HSETYRRILK VDVRFPLSMP LGARDLISRL LRYQPLERLP LAQILKHPWV QAHSRRVLPP CAQMAS //