ID Q5Y191_HUMAN PRELIMINARY; PRT; 306 AA. AC Q5Y191; DT 23-NOV-2004, integrated into UniProtKB/TrEMBL. DT 23-NOV-2004, sequence version 1. DT 13-JUN-2006, entry version 15. DE Aurora-C. GN Name=AURKC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Testis; RX PubMed=15316025; DOI=10.1074/jbc.M403029200; RA Li X., Sakashita G., Matsuzaki H., Sugimoto K., Kimura K., Hanaoka F., RA Taniguchi H., Furukawa K., Urano T.; RT "Direct association with inner centromere protein (INCENP) activates RT the novel chromosomal passenger protein, Aurora-C."; RL J. Biol. Chem. 279:47201-47211(2004). CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. CC -!- SIMILARITY: Belongs to the Ser/Thr protein kinase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY714054; AAU04399.1; -; mRNA. DR SMR; Q5Y191; 33-300. DR Ensembl; ENSG00000105146; Homo sapiens. DR RZPD-ProtExp; T1827; -. DR GO; GO:0005524; F:ATP binding; IEA. DR GO; GO:0000166; F:nucleotide binding; IEA. DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA. DR GO; GO:0016740; F:transferase activity; IEA. DR GO; GO:0006468; P:protein amino acid phosphorylation; IEA. DR InterPro; IPR011009; Kinase_like. DR InterPro; IPR000719; Prot_kinase. DR InterPro; IPR008271; Ser_thr_pkin_AS. DR InterPro; IPR002290; Ser_thr_pkinase. DR Pfam; PF00069; Pkinase; 1. DR ProDom; PD000001; Prot_kinase; 1. DR SMART; SM00220; S_TKc; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. KW ATP-binding; Kinase; Nucleotide-binding; KW Serine/threonine-protein kinase; Transferase. SQ SEQUENCE 306 AA; 35322 MW; 869FC07D176B45CE CRC64; MSSPRAVVQL GKAQPAGEES NQTAQQPSSP AMRRLTVDDF EIGRPLGKGK FGNVYLARLK ESHFIVALKV LFKSQIEKEG LEHQLRREIE IQAHLQHPNI LRLYNYFHDA RRVYLILEYA PRGELYKELQ KSEKLDEQRT ATIIEELADA LTYCHDKKVI HRDIKPENLL LGFRGEVKIA DFGWSVHTPS LRRKTMCGTL DYLPPEMIEG RTYDEKVDLW CIGVLCYELL VGYPPFESAS HSETYRRILK VDVRFPLSMP LGARDLISRL LRYQPLERLP LAQILKHPWV QAHSRRVLPP CAQMAS //