ID   FBW10_HUMAN             Reviewed;        1052 AA.
AC   Q5XX13; C9JRY8; C9JZD7; Q8TC00; Q9H0F0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   02-OCT-2024, entry version 148.
DE   RecName: Full=F-box/WD repeat-containing protein 10;
DE   AltName: Full=F-box and WD-40 domain-containing protein 10;
DE   AltName: Full=Ubiquitin ligase-specificity factor;
GN   Name=FBXW10;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Testis;
RX   PubMed=15520277; DOI=10.1101/gad.1255304;
RA   Jin J., Cardozo T., Lovering R.C., Elledge S.J., Pagano M., Harper J.W.;
RT   "Systematic analysis and nomenclature of mammalian F-box proteins.";
RL   Genes Dev. 18:2573-2580(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANTS ASN-23 AND
RP   THR-821.
RC   TISSUE=Testis;
RX   PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA   Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA   Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA   Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA   Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA   Klein M., Poustka A.;
RT   "Towards a catalog of human genes and proteins: sequencing and analysis of
RT   500 novel complete protein coding human cDNAs.";
RL   Genome Res. 11:422-435(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 630-837 (ISOFORM 4).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=20498703; DOI=10.1371/journal.pone.0010620;
RA   Chaturvedi P., Parnaik V.K.;
RT   "Lamin A rod domain mutants target heterochromatin protein 1alpha and beta
RT   for proteasomal degradation by activation of F-box protein, FBXW10.";
RL   PLoS ONE 5:E10620-E10620(2010).
CC   -!- FUNCTION: Probable substrate-recognition component of a SCF (SKP1-CUL1-
CC       F-box protein)-type E3 ubiquitin ligase complex which mediates the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins. Overexpression is leading to degradation of CBX5 and CBX1.
CC       {ECO:0000269|PubMed:20498703}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q5XX13-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5XX13-2; Sequence=VSP_030727, VSP_030729;
CC       Name=3;
CC         IsoId=Q5XX13-3; Sequence=VSP_030728;
CC       Name=4;
CC         IsoId=Q5XX13-4; Sequence=VSP_039178;
CC   -!- INDUCTION: By disease-causing laminin A mutants also inducing CBX5 and
CC       CBX1 proteasomal degradation. {ECO:0000269|PubMed:20498703}.
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DR   EMBL; AY729024; AAU43731.1; -; mRNA.
DR   EMBL; AL136822; CAB66756.1; -; mRNA.
DR   EMBL; AC107982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC028364; AAH28364.1; -; mRNA.
DR   EMBL; BI828401; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS11199.3; -. [Q5XX13-1]
DR   CCDS; CCDS58524.1; -. [Q5XX13-3]
DR   CCDS; CCDS92270.1; -. [Q5XX13-2]
DR   RefSeq; NP_001254514.1; NM_001267585.1. [Q5XX13-1]
DR   RefSeq; NP_001254515.1; NM_001267586.1. [Q5XX13-3]
DR   AlphaFoldDB; Q5XX13; -.
DR   SMR; Q5XX13; -.
DR   BioGRID; 115772; 4.
DR   ComplexPortal; CPX-7786; SCF E3 ubiquitin ligase complex, FBXW10 variant.
DR   IntAct; Q5XX13; 2.
DR   STRING; 9606.ENSP00000379025; -.
DR   GlyGen; Q5XX13; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q5XX13; -.
DR   PhosphoSitePlus; Q5XX13; -.
DR   BioMuta; FBXW10; -.
DR   DMDM; 296434504; -.
DR   MassIVE; Q5XX13; -.
DR   PaxDb; 9606-ENSP00000379025; -.
DR   PeptideAtlas; Q5XX13; -.
DR   Antibodypedia; 13562; 80 antibodies from 13 providers.
DR   DNASU; 10517; -.
DR   Ensembl; ENST00000301938.4; ENSP00000306937.4; ENSG00000171931.13. [Q5XX13-3]
DR   Ensembl; ENST00000308799.8; ENSP00000310382.4; ENSG00000171931.13. [Q5XX13-2]
DR   Ensembl; ENST00000395665.9; ENSP00000379025.4; ENSG00000171931.13. [Q5XX13-1]
DR   GeneID; 10517; -.
DR   KEGG; hsa:10517; -.
DR   MANE-Select; ENST00000395665.9; ENSP00000379025.4; NM_001267585.2; NP_001254514.1.
DR   UCSC; uc002guk.4; human. [Q5XX13-1]
DR   AGR; HGNC:1211; -.
DR   CTD; 10517; -.
DR   DisGeNET; 10517; -.
DR   GeneCards; FBXW10; -.
DR   HGNC; HGNC:1211; FBXW10.
DR   HPA; ENSG00000171931; Tissue enriched (testis).
DR   MIM; 611679; gene.
DR   neXtProt; NX_Q5XX13; -.
DR   OpenTargets; ENSG00000171931; -.
DR   PharmGKB; PA25575; -.
DR   VEuPathDB; HostDB:ENSG00000171931; -.
DR   eggNOG; KOG0274; Eukaryota.
DR   GeneTree; ENSGT00940000158003; -.
DR   HOGENOM; CLU_011071_0_0_1; -.
DR   InParanoid; Q5XX13; -.
DR   OMA; AYHGQET; -.
DR   OrthoDB; 5405718at2759; -.
DR   PhylomeDB; Q5XX13; -.
DR   TreeFam; TF329175; -.
DR   PathwayCommons; Q5XX13; -.
DR   Reactome; R-HSA-390471; Association of TriC/CCT with target proteins during biosynthesis.
DR   Reactome; R-HSA-8951664; Neddylation.
DR   Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   SignaLink; Q5XX13; -.
DR   SIGNOR; Q5XX13; -.
DR   BioGRID-ORCS; 10517; 16 hits in 1184 CRISPR screens.
DR   ChiTaRS; FBXW10; human.
DR   GeneWiki; FBXW10; -.
DR   GenomeRNAi; 10517; -.
DR   Pharos; Q5XX13; Tbio.
DR   PRO; PR:Q5XX13; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q5XX13; protein.
DR   Bgee; ENSG00000171931; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 83 other cell types or tissues.
DR   ExpressionAtlas; Q5XX13; baseline and differential.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   CDD; cd22136; F-box_FBXW10; 1.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 1.20.1280.50; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR051075; SCF_subunit_WD-repeat.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR19872:SF7; F-BOX AND WD REPEAT DOMAIN CONTAINING PROTEIN 10B-RELATED; 1.
DR   PANTHER; PTHR19872; UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Proteomics identification;
KW   Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..1052
FT                   /note="F-box/WD repeat-containing protein 10"
FT                   /id="PRO_0000315834"
FT   REPEAT          169..206
FT                   /note="WD 1"
FT   DOMAIN          276..323
FT                   /note="F-box"
FT   REPEAT          409..447
FT                   /note="WD 2"
FT   REPEAT          451..490
FT                   /note="WD 3"
FT   REPEAT          493..532
FT                   /note="WD 4"
FT   REPEAT          534..569
FT                   /note="WD 5"
FT   REPEAT          572..609
FT                   /note="WD 6"
FT   REPEAT          611..652
FT                   /note="WD 7"
FT   REGION          766..805
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          690..719
FT                   /evidence="ECO:0000255"
FT   COILED          986..1010
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        770..787
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         291
FT                   /note="R -> SMLGCMRGFPRHLPSWPSSGVSGSIFFFPG (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_030727"
FT   VAR_SEQ         617..669
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:11230166"
FT                   /id="VSP_030728"
FT   VAR_SEQ         760..779
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_030729"
FT   VAR_SEQ         779
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_039178"
FT   VARIANT         23
FT                   /note="I -> N (in dbSNP:rs11544711)"
FT                   /evidence="ECO:0000269|PubMed:11230166"
FT                   /id="VAR_038341"
FT   VARIANT         372
FT                   /note="R -> G (in dbSNP:rs7209610)"
FT                   /id="VAR_057600"
FT   VARIANT         821
FT                   /note="A -> T (in dbSNP:rs1026259)"
FT                   /evidence="ECO:0000269|PubMed:11230166"
FT                   /id="VAR_038342"
FT   CONFLICT        236
FT                   /note="E -> K (in Ref. 2; CAB66756)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        275
FT                   /note="R -> L (in Ref. 1; AAU43731 and 4; AAH28364)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        413
FT                   /note="D -> V (in Ref. 2; CAB66756)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        638
FT                   /note="R -> L (in Ref. 1; AAU43731)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1052 AA;  119846 MW;  C5FDFC2824E918F4 CRC64;
     MENLESRLKN APYFRCEKGT DSIPLCRKCE TCVLAWKIFS TKEWFCRIND ISQRRFLVGI
     LKQLNSLYLL HYFQNILQTT QGKDFIYNRS RINLSKKEGK VVKSSLNQML DKTVEQKMKE
     ILYWFANSTQ WTKANYTLLL LQMCNPKLLL TAANVIRVLF LREENNISGL NQDITDVCFS
     PEKDHSSKSA TSQVYWTAKT QHTSLPLSKA PENEHLLGAA SNPEEPWRNS LRCISEMNRL
     FSGKGDITKP GYDPCNLLVD LDDIRDLSSG FSKYRDFIRY LPIHLSKYIL RMLDRHTLNK
     CASVSQHWAA MAQQVKMDLS AHGFIQNQIT FLQGSYTRGI DPNYANKVSI PVPKMVDDGK
     SMRVKHPKWK LRTKNEYNLW TAYQNEETQQ VLIEERNVFC GTYNVRILSD TWDQNRVIHY
     SGGDLIAVSS NRKIHLLDII QVKAIPVEFR GHAGSVRALF LCEEENFLLS GSYDLSIRYW
     DLKSGVCTRI FGGHQGTITC MDLCKNRLVS GGRDCQVKVW DVDTGKCLKT FRHKDPILAT
     RINDTYIVSS CERGLVKVWH IAMAQLVKTL SGHEGAVKCL FFDQWHLLSG STDGLVMAWS
     MVGKYERCLM AFKHPKEVLD VSLLFLRVIS ACADGKIRIY NFLNGNCMKV LKANGRGDPV
     LSFFIQGNRM VVNTESNVLM FQFEHIKWQY AVEKTKQKKN KEKEEEKEEN SLMEILSKCN
     IQVHSPRESV SSKQTVIQEL LPGKPPKSRV LLKPAKFSSA VLIEELQSQG KSKSPRRDAD
     DVEKAQKQGQ LETPGKLPSH PKKKSWKIPM SPDQFLLTVS ALQHAHNSGE FAYPCRPQTE
     ITDVWGPSIS YPRKVLNFKG KSIQRAVDRL RLSNPPIDVK RTSIPLEIQK LQPNLKISLH
     SPRVQSTIPQ PMIIRSRFSG SLKGGDQVTS SIERAVCSTG PLTSMQVIKP NRMLAPQVGT
     ATLSLKKERP RIYTALDPFR VNTEFVLLTV KEEKEHQEAK MKEYQAREST GVVDPGKVSK
     AAWIRKIKGL PIDNFTKQGK TAAPELGQNV FI
//