ID Q5WDG8_BACSK Unreviewed; 957 AA. AC Q5WDG8; DT 23-NOV-2004, integrated into UniProtKB/TrEMBL. DT 23-NOV-2004, sequence version 1. DT 10-AUG-2010, entry version 47. DE SubName: Full=Excinuclease ABC subunit A UvrA; GN Name=uvrA; OrderedLocusNames=ABC3058; OS Bacillus clausii (strain KSM-K16). OC Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus. OX NCBI_TaxID=66692; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., RA Kawai S., Ito S., Horikoshi K.; RT "The complete genome sequence of the alkaliphilic Bacillus clausii RT KSM-K16."; RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding CC protein. A damage recognition complex composed of 2 uvrA and 2 CC uvrB subunits scans DNA for abnormalities. When the presence of a CC lesion has been verified by uvrB, the uvrA molecules dissociate CC (By similarity). CC -!- SUBUNIT: Forms a heterotetramer with uvrB during the search for CC lesions (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP006627; BAD65592.1; -; Genomic_DNA. DR RefSeq; YP_176553.1; -. DR ProteinModelPortal; Q5WDG8; -. DR SMR; Q5WDG8; 4-949. DR STRING; Q5WDG8; -. DR EnsemblBacteria; EBBACT00000047098; EBBACP00000045859; EBBACG00000047089. DR GeneID; 3203580; -. DR GenomeReviews; AP006627_GR; ABC3058. DR KEGG; bcl:ABC3058; -. DR NMPDR; fig|66692.3.peg.2968; -. DR eggNOG; COG0178; -. DR HOGENOM; HBG284763; -. DR OMA; GAIKGWD; -. DR ProtClustDB; PRK00349; -. DR BioCyc; BCLA66692:ABC3058-MONOMER; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0016887; F:ATPase activity; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0009381; F:excinuclease ABC activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro. DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW. DR InterPro; IPR003439; ABC_transporter-like. DR InterPro; IPR017871; ABC_transporter_CS. DR InterPro; IPR003593; ATPase_AAA+_core. DR InterPro; IPR004602; UvrA_ABC. DR Pfam; PF00005; ABC_tran; 2. DR SMART; SM00382; AAA; 2. DR TIGRFAMs; TIGR00630; uvra; 1. DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2. DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2. PE 3: Inferred from homology; KW ATP-binding; Complete proteome; Cytoplasm; DNA damage; DNA excision; KW DNA repair; DNA-binding; Excision nuclease; Metal-binding; KW Nucleotide-binding; Repeat; SOS response; Zinc. SQ SEQUENCE 957 AA; 106013 MW; 5502EDC703CF6891 CRC64; MAHEQIVVKG ARSNNLKNMD VTIPRDKLVV LTGLSGSGKS SLAFDTIYAE GQRRYVESLS AYARQFLGQM DKPDVDSIEG LSPAISIDQK TTSRNPRSTV GTVTEIHDYL RLLYARIGRP VCPRHGIEIS SQTIEQMVDR LLEYPERTKM QILAPLVSGR KGTHVKTLEQ IKRDGYVRIR VDGEMREASE EIELDKNKKH TIEVVIDRIV IKEGVQARIA DSLETALTLA GGRVLVDVIG EEELLFSQQH ACPECGFSIP ELEPRLFSFN SPFGACPSCD GLGSKQEVDS ELVVPDPSRS LREHALAPWE PTSSNYYPQL LQAVCDHFGI DMDVPFEKLP ATQQQILLEG SGKEKIFFRY ENDFGRVHEH TIVFEGVLAN VARRYRETSS DYIREQMEMY MSQKKCPTCK GYRLKKEALA VFVGGKHLGE VSQMTCTDAI QFVKSLDLTE KERAIARLII KEIEDRLGFL VNVGLDYLTL SRAAGTLSGG EAQRIRLATQ IGSSLMGVLY ILDEPSIGLH QRDNDRLIET LKHMRDLGNT LIVVEHDEDT MLAADHIIDI GPGAGMHGGY ITAQGTPKEL TENPHSLTGK YLSGEKFIPV PRERRPLTDR SFTVKKASAN NLKNIDVTFP LGVFIAVTGV SGSGKSTLVN EIVHKALAQR IHRAKAKPGP HKEIIGIDEM DKVIDIDQSP IGRTPRSNPA TYTSMFDDIR DVFAMTNEAK VRGYKKGRFS FNVKGGRCEA CKGDGIIKIE MHFLPDVYVP CEVCHGKRYN RETLEVTYKG KTIADVLEMT IEEGAEFFAS IPKINRKIQT LIDVGLGYLK MGQPATTLSG GEAQRVKLAS QLHKRSTGRT LYILDEPTTG LHVDDIARLL KVLQRLVDNG DTVLVIEHNL DVIKTADHII DLGPEGGKNG GTIVAEGTPE HVAETSASYT GAYLKPILAR DKARQEALFA GAEQKSS //