ID CT094_HUMAN Reviewed; 408 AA. AC Q5VYV7; Q05CG2; Q05CT9; DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot. DT 07-DEC-2004, sequence version 1. DT 08-FEB-2011, entry version 45. DE RecName: Full=UPF0492 protein C20orf94; GN Name=C20orf94; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=21638749; PubMed=11780052; DOI=10.1038/414865a; RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., RA Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 20."; RL Nature 414:865-871(2001). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Prostate; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-396, AND MASS RP SPECTROMETRY. RC TISSUE=Cervix carcinoma; RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007; RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., RA Greff Z., Keri G., Stemmann O., Mann M.; RT "Kinase-selective enrichment enables quantitative phosphoproteomics of RT the kinome across the cell cycle."; RL Mol. Cell 31:438-448(2008). RN [4] RP INTERACTION WITH SLX4. RX PubMed=19596235; DOI=10.1016/j.cell.2009.06.030; RA Svendsen J.M., Smogorzewska A., Sowa M.E., O'Connell B.C., Gygi S.P., RA Elledge S.J., Harper J.W.; RT "Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is RT required for DNA repair."; RL Cell 138:63-77(2009). CC -!- SUBUNIT: Interacts with SLX4/BTBD12; subunit of different CC structure-specific endonucleases. CC -!- SIMILARITY: Belongs to the UPF0492 family. CC -!- SEQUENCE CAUTION: CC Sequence=AAH20787.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; CC Sequence=AAH26094.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL133340; CAH71244.1; -; Genomic_DNA. DR EMBL; AL035456; CAH71244.1; JOINED; Genomic_DNA. DR EMBL; AL353599; CAH71244.1; JOINED; Genomic_DNA. DR EMBL; AL353599; CAH71745.1; -; Genomic_DNA. DR EMBL; AL035456; CAH71745.1; JOINED; Genomic_DNA. DR EMBL; AL133340; CAH71745.1; JOINED; Genomic_DNA. DR EMBL; AL035456; CAI42184.1; -; Genomic_DNA. DR EMBL; AL133340; CAI42184.1; JOINED; Genomic_DNA. DR EMBL; AL353599; CAI42184.1; JOINED; Genomic_DNA. DR EMBL; BC020787; AAH20787.1; ALT_SEQ; mRNA. DR EMBL; BC026094; AAH26094.1; ALT_SEQ; mRNA. DR IPI; IPI00046188; -. DR RefSeq; NP_001009608.1; NM_001009608.1. DR UniGene; Hs.668782; -. DR ProteinModelPortal; Q5VYV7; -. DR IntAct; Q5VYV7; 22. DR STRING; Q5VYV7; -. DR PhosphoSite; Q5VYV7; -. DR PRIDE; Q5VYV7; -. DR Ensembl; ENST00000334534; ENSP00000335557; ENSG00000149346. DR GeneID; 128710; -. DR KEGG; hsa:128710; -. DR UCSC; uc002wnv.1; human. DR CTD; 128710; -. DR GeneCards; GC20P010410; -. DR HGNC; HGNC:16225; C20orf94. DR neXtProt; NX_Q5VYV7; -. DR PharmGKB; PA25801; -. DR eggNOG; prNOG05842; -. DR GeneTree; ENSGT00390000016400; -. DR HOGENOM; HBG403017; -. DR HOVERGEN; HBG094893; -. DR InParanoid; Q5VYV7; -. DR OMA; LPVQKLE; -. DR OrthoDB; EOG9N5ZGM; -. DR PhylomeDB; Q5VYV7; -. DR NextBio; 82430; -. DR ArrayExpress; Q5VYV7; -. DR Bgee; Q5VYV7; -. DR CleanEx; HS_C20orf94; -. DR Genevestigator; Q5VYV7; -. DR GO; GO:0005515; F:protein binding; IPI:UniProtKB. PE 1: Evidence at protein level; KW Complete proteome; Phosphoprotein; Polymorphism. FT CHAIN 1 408 UPF0492 protein C20orf94. FT /FTId=PRO_0000306119. FT MOD_RES 396 396 Phosphoserine. FT VARIANT 317 317 R -> Q (in dbSNP:rs6077853). FT /FTId=VAR_035277. SQ SEQUENCE 408 AA; 45552 MW; 4CBC9DF90E3B14E9 CRC64; MASKKFAVKC GNFAVLVDLH ILPQGSNKDT SWFSEQKKEE VCLLLKETID SRVQEYLEVR KQHRPSNAEF TRSNPLSLKG YGFQITAYFL KRGIRLRCIR STQNAELCVF PDRFVVCVSQ LAFSRDLLAS QNEDLTERVL HGVSDYFAEC AESSLPPSAK LRRNALKEIV KRTETKSSVT SKSQTRRDTV ETSSDSVIAE IARRRNDGQA SSSPPSESMG QAKDSIKAAE SHWGLPVQKL EKVNQTQPED TSGQQKPHPG ERLKTGLLSR SPVCSCESAS PCPKQSPRVA KTQQKRRNCS SAEDFDHHGR VSLGSDRLVP REIIVEKSKA VRVLPASELS DPGLLLKQDL AKTTSKEELH VLESLSSRHL MKNNPGQAQQ TGLATNTERL STIQNSPTKK RKKYERGH //