ID SNX30_HUMAN Reviewed; 437 AA. AC Q5VWJ9; DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot. DT 07-DEC-2004, sequence version 1. DT 13-SEP-2023, entry version 145. DE RecName: Full=Sorting nexin-30 {ECO:0000303|PubMed:32513819}; GN Name=SNX30 {ECO:0000303|PubMed:32513819, ECO:0000312|HGNC:HGNC:23685}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., RA Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [2] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [3] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [6] RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH SNX4. RX PubMed=32513819; DOI=10.1242/jcs.246306; RA Anton Z., Betin V.M.S., Simonetti B., Traer C.J., Attar N., Cullen P.J., RA Lane J.D.; RT "A heterodimeric SNX4--SNX7 SNX-BAR autophagy complex coordinates ATG9A RT trafficking for efficient autophagosome assembly."; RL J. Cell Sci. 133:0-0(2020). CC -!- FUNCTION: Involved in the regulation of endocytosis and in several CC stages of intracellular trafficking (PubMed:32513819). Together with CC SNX4, involved in autophagosome assembly (PubMed:32513819). CC {ECO:0000269|PubMed:32513819}. CC -!- SUBUNIT: Heterodimer; heterodimerizes with SNX4. CC {ECO:0000269|PubMed:32513819}. CC -!- INTERACTION: CC Q5VWJ9; O95219: SNX4; NbExp=3; IntAct=EBI-8099676, EBI-724909; CC -!- SUBCELLULAR LOCATION: Early endosome membrane CC {ECO:0000269|PubMed:32513819}; Peripheral membrane protein CC {ECO:0000250|UniProtKB:O95219}; Cytoplasmic side CC {ECO:0000250|UniProtKB:O95219}. CC -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL390067; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL360235; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL139041; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR CCDS; CCDS43865.1; -. DR RefSeq; NP_001013012.1; NM_001012994.1. DR AlphaFoldDB; Q5VWJ9; -. DR SMR; Q5VWJ9; -. DR BioGRID; 135142; 24. DR IntAct; Q5VWJ9; 6. DR MINT; Q5VWJ9; -. DR STRING; 9606.ENSP00000363349; -. DR GlyGen; Q5VWJ9; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q5VWJ9; -. DR MetOSite; Q5VWJ9; -. DR PhosphoSitePlus; Q5VWJ9; -. DR BioMuta; SNX30; -. DR DMDM; 74747407; -. DR EPD; Q5VWJ9; -. DR jPOST; Q5VWJ9; -. DR MassIVE; Q5VWJ9; -. DR MaxQB; Q5VWJ9; -. DR PaxDb; Q5VWJ9; -. DR PeptideAtlas; Q5VWJ9; -. DR ProteomicsDB; 65531; -. DR Antibodypedia; 7509; 106 antibodies from 19 providers. DR DNASU; 401548; -. DR Ensembl; ENST00000374232.8; ENSP00000363349.3; ENSG00000148158.17. DR GeneID; 401548; -. DR KEGG; hsa:401548; -. DR MANE-Select; ENST00000374232.8; ENSP00000363349.3; NM_001012994.2; NP_001013012.1. DR UCSC; uc004bgj.5; human. DR AGR; HGNC:23685; -. DR CTD; 401548; -. DR DisGeNET; 401548; -. DR GeneCards; SNX30; -. DR HGNC; HGNC:23685; SNX30. DR HPA; ENSG00000148158; Tissue enhanced (brain). DR neXtProt; NX_Q5VWJ9; -. DR OpenTargets; ENSG00000148158; -. DR PharmGKB; PA142670889; -. DR VEuPathDB; HostDB:ENSG00000148158; -. DR eggNOG; KOG2273; Eukaryota. DR GeneTree; ENSGT00940000158994; -. DR HOGENOM; CLU_040655_1_0_1; -. DR InParanoid; Q5VWJ9; -. DR OMA; WSLHRFI; -. DR OrthoDB; 5475877at2759; -. DR PhylomeDB; Q5VWJ9; -. DR TreeFam; TF328543; -. DR PathwayCommons; Q5VWJ9; -. DR SignaLink; Q5VWJ9; -. DR BioGRID-ORCS; 401548; 12 hits in 1153 CRISPR screens. DR ChiTaRS; SNX30; human. DR GenomeRNAi; 401548; -. DR Pharos; Q5VWJ9; Tdark. DR PRO; PR:Q5VWJ9; -. DR Proteomes; UP000005640; Chromosome 9. DR RNAct; Q5VWJ9; Protein. DR Bgee; ENSG00000148158; Expressed in kidney epithelium and 174 other tissues. DR ExpressionAtlas; Q5VWJ9; baseline and differential. DR Genevisible; Q5VWJ9; HS. DR GO; GO:0005769; C:early endosome; IDA:UniProtKB. DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central. DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro. DR GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central. DR GO; GO:0032456; P:endocytic recycling; IBA:GO_Central. DR GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IBA:GO_Central. DR GO; GO:2000786; P:positive regulation of autophagosome assembly; IMP:UniProtKB. DR GO; GO:0015031; P:protein transport; IMP:UniProtKB. DR GO; GO:0061709; P:reticulophagy; IBA:GO_Central. DR CDD; cd07667; BAR_SNX30; 1. DR CDD; cd06860; PX_SNX7_30_like; 1. DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1. DR Gene3D; 3.30.1520.10; Phox-like domain; 1. DR InterPro; IPR027267; AH/BAR_dom_sf. DR InterPro; IPR001683; PX_dom. DR InterPro; IPR036871; PX_dom_sf. DR InterPro; IPR028649; SNX30_BAR. DR PANTHER; PTHR45949:SF1; SORTING NEXIN-30; 1. DR PANTHER; PTHR45949; SORTING NEXIN-4; 1. DR Pfam; PF00787; PX; 1. DR SMART; SM00312; PX; 1. DR SUPFAM; SSF103657; BAR/IMD domain-like; 1. DR SUPFAM; SSF64268; PX domain; 1. DR PROSITE; PS50195; PX; 1. PE 1: Evidence at protein level; KW Endosome; Membrane; Phosphoprotein; Protein transport; Reference proteome; KW Transport. FT CHAIN 1..437 FT /note="Sorting nexin-30" FT /id="PRO_0000284533" FT DOMAIN 89..210 FT /note="PX" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147" FT DOMAIN 234..437 FT /note="BAR" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00361" FT REGION 1..44 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 54..73 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 132 FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- FT inositol-3-phosphate)" FT /ligand_id="ChEBI:CHEBI:58088" FT /evidence="ECO:0000250|UniProtKB:Q3UR97" FT BINDING 134 FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- FT inositol-3-phosphate)" FT /ligand_id="ChEBI:CHEBI:58088" FT /evidence="ECO:0000250|UniProtKB:Q3UR97" FT BINDING 162 FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- FT inositol-3-phosphate)" FT /ligand_id="ChEBI:CHEBI:58088" FT /evidence="ECO:0000250|UniProtKB:Q96L94" FT BINDING 176 FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- FT inositol-3-phosphate)" FT /ligand_id="ChEBI:CHEBI:58088" FT /evidence="ECO:0000250|UniProtKB:Q6P4T1" FT MOD_RES 38 FT /note="Phosphothreonine" FT /evidence="ECO:0000250|UniProtKB:Q8CE50" FT MOD_RES 40 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648, FT ECO:0007744|PubMed:20068231" FT VARIANT 83 FT /note="D -> H (in dbSNP:rs1485070286)" FT /id="VAR_031771" FT VARIANT 125 FT /note="P -> A (in dbSNP:rs10117709)" FT /id="VAR_052483" SQ SEQUENCE 437 AA; 49677 MW; 32496ED341C5E9A4 CRC64; MAGGPPKALP STGPHSLRDM PHPLAGSSSE EAVGGDSTPS PDLLMARSFG DKDLILPNGG TPAGTSSPAS SSSLLNRLQL DDDIDGETRD LFVIVDDPKK HVCTMETYIT YRITTKSTRV EFDLPEYSVR RRYQDFDWLR SKLEESQPTH LIPPLPEKFV VKGVVDRFSE EFVETRRKAL DKFLKRITDH PVLSFNEHFN IFLTAKDLNA YKKQGIALLT RMGESVKHVT GGYKLRTRPL EFAAIGDYLD TFALKLGTID RIAQRIIKEE IEYLVELREY GPVYSTWSAL EGELAEPLEG VSACIGNCST ALEELTDDMT EDFLPVLREY ILYSDSMKSV LKKRDQVQAE YEAKLEAVAL RKEDRPKVPA DVEKCQDRME CFNADLKADM ERWQNNKRQD FRQLLMGMAD KNIQYYEKCL MAWESIIPLL QEKQEAK //