ID CBPC6_HUMAN Reviewed; 540 AA. AC Q5VU57; DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot. DT 17-APR-2007, sequence version 2. DT 29-APR-2008, entry version 27. DE Cytosolic carboxypeptidase 6 (EC 3.4.17.-) (ATP/GTP-binding protein- DE like 4). GN Name=AGBL4; Synonyms=CCP6; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., RA Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). CC -!- FUNCTION: May play a role in the processing of tubulin (By CC similarity). CC -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the peptidase M14 family. CC -!- SEQUENCE CAUTION: CC Sequence=CAH70510.1; Type=Erroneous gene model prediction; CC Sequence=CAI13521.1; Type=Erroneous gene model prediction; CC Sequence=CAI14372.1; Type=Erroneous gene model prediction; CC Sequence=CAI17069.1; Type=Erroneous gene model prediction; CC Sequence=CAI19137.1; Type=Erroneous gene model prediction; CC Sequence=CAI22167.1; Type=Erroneous gene model prediction; CC Sequence=CAI23365.1; Type=Erroneous gene model prediction; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK094826; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AL590432; CAH70510.1; ALT_SEQ; Genomic_DNA. DR EMBL; AC099788; CAH70510.1; JOINED; Genomic_DNA. DR EMBL; AL355809; CAH70510.1; JOINED; Genomic_DNA. DR EMBL; AL390023; CAH70510.1; JOINED; Genomic_DNA. DR EMBL; AL391844; CAH70510.1; JOINED; Genomic_DNA. DR EMBL; AL591602; CAH70510.1; JOINED; Genomic_DNA. DR EMBL; AL645507; CAH70510.1; JOINED; Genomic_DNA. DR EMBL; AL645730; CAH70510.1; JOINED; Genomic_DNA. DR EMBL; AL391844; CAI13521.1; ALT_SEQ; Genomic_DNA. DR EMBL; AC099788; CAI13521.1; JOINED; Genomic_DNA. DR EMBL; AL355809; CAI13521.1; JOINED; Genomic_DNA. DR EMBL; AL390023; CAI13521.1; JOINED; Genomic_DNA. DR EMBL; AL590432; CAI13521.1; JOINED; Genomic_DNA. DR EMBL; AL591602; CAI13521.1; JOINED; Genomic_DNA. DR EMBL; AL645507; CAI13521.1; JOINED; Genomic_DNA. DR EMBL; AL645730; CAI13521.1; JOINED; Genomic_DNA. DR EMBL; AL645507; CAI14372.1; ALT_SEQ; Genomic_DNA. DR EMBL; AC099788; CAI14372.1; JOINED; Genomic_DNA. DR EMBL; AL355809; CAI14372.1; JOINED; Genomic_DNA. DR EMBL; AL390023; CAI14372.1; JOINED; Genomic_DNA. DR EMBL; AL391844; CAI14372.1; JOINED; Genomic_DNA. DR EMBL; AL590432; CAI14372.1; JOINED; Genomic_DNA. DR EMBL; AL591602; CAI14372.1; JOINED; Genomic_DNA. DR EMBL; AL645730; CAI14372.1; JOINED; Genomic_DNA. DR EMBL; AL645730; CAI17069.1; ALT_SEQ; Genomic_DNA. DR EMBL; AC099788; CAI17069.1; JOINED; Genomic_DNA. DR EMBL; AL355809; CAI17069.1; JOINED; Genomic_DNA. DR EMBL; AL390023; CAI17069.1; JOINED; Genomic_DNA. DR EMBL; AL391844; CAI17069.1; JOINED; Genomic_DNA. DR EMBL; AL590432; CAI17069.1; JOINED; Genomic_DNA. DR EMBL; AL591602; CAI17069.1; JOINED; Genomic_DNA. DR EMBL; AL645507; CAI17069.1; JOINED; Genomic_DNA. DR EMBL; AL591602; CAI19137.1; ALT_SEQ; Genomic_DNA. DR EMBL; AC099788; CAI19137.1; JOINED; Genomic_DNA. DR EMBL; AL355809; CAI19137.1; JOINED; Genomic_DNA. DR EMBL; AL390023; CAI19137.1; JOINED; Genomic_DNA. DR EMBL; AL391844; CAI19137.1; JOINED; Genomic_DNA. DR EMBL; AL590432; CAI19137.1; JOINED; Genomic_DNA. DR EMBL; AL645507; CAI19137.1; JOINED; Genomic_DNA. DR EMBL; AL645730; CAI19137.1; JOINED; Genomic_DNA. DR EMBL; AL355809; CAI22167.1; ALT_SEQ; Genomic_DNA. DR EMBL; AC099788; CAI22167.1; JOINED; Genomic_DNA. DR EMBL; AL390023; CAI22167.1; JOINED; Genomic_DNA. DR EMBL; AL391844; CAI22167.1; JOINED; Genomic_DNA. DR EMBL; AL590432; CAI22167.1; JOINED; Genomic_DNA. DR EMBL; AL591602; CAI22167.1; JOINED; Genomic_DNA. DR EMBL; AL645507; CAI22167.1; JOINED; Genomic_DNA. DR EMBL; AL645730; CAI22167.1; JOINED; Genomic_DNA. DR EMBL; AL390023; CAI23365.1; ALT_SEQ; Genomic_DNA. DR EMBL; AC099788; CAI23365.1; JOINED; Genomic_DNA. DR EMBL; AL355809; CAI23365.1; JOINED; Genomic_DNA. DR EMBL; AL391844; CAI23365.1; JOINED; Genomic_DNA. DR EMBL; AL590432; CAI23365.1; JOINED; Genomic_DNA. DR EMBL; AL591602; CAI23365.1; JOINED; Genomic_DNA. DR EMBL; AL645507; CAI23365.1; JOINED; Genomic_DNA. DR EMBL; AL645730; CAI23365.1; JOINED; Genomic_DNA. DR Ensembl; ENSG00000186094; Homo sapiens. DR HGNC; HGNC:25892; AGBL4. DR PharmGKB; PA142672636; -. DR ArrayExpress; Q5VU57; -. DR InterPro; IPR000834; Peptidase_M14. DR Pfam; PF00246; Peptidase_M14; 1. DR PROSITE; PS00132; CARBOXYPEPT_ZN_1; FALSE_NEG. DR PROSITE; PS00133; CARBOXYPEPT_ZN_2; FALSE_NEG. PE 2: Evidence at transcript level; KW Carboxypeptidase; Cytoplasm; Hydrolase; Metal-binding; KW Metalloprotease; Protease; Zinc. FT CHAIN 1 540 Cytosolic carboxypeptidase 6. FT /FTId=PRO_0000284835. FT ACT_SITE 280 280 Nucleophile (By similarity). FT METAL 230 230 Zinc (By similarity). FT METAL 233 233 Zinc (By similarity). FT METAL 328 328 Zinc (By similarity). SQ SEQUENCE 540 AA; 62385 MW; 139DEC2993F2DCF5 CRC64; MAEGSQSAPE AGNDMGNDDA IGGNVSKYIV LPTGYCGQPK KGHLIFDACF ESGNLGRVDQ VSEFEYDLFI RPDTCNPRFR VWFNFTVENV KESQRVIFNI VNFSKTKSLY RDGMAPMVKS TSRPKWQRLP PKNVYYYRCP DHRKNYVMSF AFCFDREEDI YQFAYCYPYT YTRFQHYLDS LQKRNMDYFF REQLGQSVQQ RKLDLLTITS PDNLREGAEQ KVVFITGRVH PGETPSSFVC QGIIDFLVSQ HPIACVLREY LVFKIAPMLN PDGVYLGNYR CSLMGFDLNR HWLDPSPWVH PTLHGVKQLI VQMYNDPKTS LEFYIDIHAH STMMNGFMYG NIFEDEERFQ RQAIFPKLLC QNAEDFSYSS TSFNRDAVKA GTGRRFLGGL LDHTSYCYTL EVSFYSYIIS GTTAAVPYTE EAYMKLGRNV ARTFLDYYRL NPVVEKVAIP MPRLRNKEIE VQRRKEKSPP YKHPLLRGPA SNYPNSKGDK KSSVNHKDPS TPFLKTRSPG RSYGDRSMHF LLGNEINHSS LASKDLWINA //