ID COBB_HALMA STANDARD; PRT; 439 AA. AC Q5V341; DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot. DT 07-DEC-2004, sequence version 1. DT 30-MAY-2006, entry version 14. DE Probable cobyrinic acid A,C-diamide synthase. GN Name=cobB; OrderedLocusNames=rrnAC1102; OS Haloarcula marismortui (Halobacterium marismortui). OC Archaea; Euryarchaeota; Halobacteria; Halobacteriales; OC Halobacteriaceae; Haloarcula. OX NCBI_TaxID=2238; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 43049 / DSM 3752 / JCM 8966; RX PubMed=15520287; DOI=10.1101/gr.2700304; RA Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., RA Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., RA Date S.V., Marcotte E., Hood L., Ng W.V.; RT "Genome sequence of Haloarcula marismortui: a halophilic archaeon from RT the Dead Sea."; RL Genome Res. 14:2221-2234(2004). CC -!- FUNCTION: Responsible for the amidation of carboxylic groups at CC position A and C of either cobyrinic acid or hydrogenobrynic acid. CC NH(2) groups are provided by glutamine, and one molecule of ATP is CC hydrogenolyzed for each amidation (By similarity). CC -!- PATHWAY: Cobalamin biosynthesis. CC -!- SIMILARITY: Belongs to the cobB/cobQ family. CobB subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY596297; AAV46061.1; -; Genomic_DNA. DR GenomeReviews; AY596297_GR; rrnAC1102. DR HAMAP; MF_00027; -; 1. DR InterPro; IPR002586; CbiA_P_synth. DR InterPro; IPR004484; CbiA_synth. DR InterPro; IPR011698; GATase_3. DR Pfam; PF01656; CbiA; 1. DR Pfam; PF07685; GATase_3; 1. DR TIGRFAMs; TIGR00379; cobB; 1. KW Cobalamin biosynthesis; Complete proteome. FT CHAIN 1 439 Probable cobyrinic acid A,C-diamide FT synthase. FT /FTId=PRO_0000141274. SQ SEQUENCE 439 AA; 46284 MW; F49FFAFC63D97D5C CRC64; MEGFVLAGTS SGVGKTVATL ATLTALEDAG YQPQPAKAGP DFIDPSHHEA LVDTPSRTLD PWLAGEDGMR RTYWRGTGDI CVVEGVMGLY DGTKTSTAAV AEGLDLPVVL VVDAKAGMES VAATALGFAQ YADRIGVDIE VAGILAQRAH GGRHADGIRD ALPEDLTYFG RIPPMSDLEI PDRHLGLHMG SEAGLDRDAL STAAETIDIE RLVETARAPP EVATTERNTG DSPADRRVAV AQDSAFCFIY PSVLERLRSE ASVEPFSPVA GDSVPDADAI YLPGGYPELH GESLETGGTL DEIAVRAADG VPVYGECGGL MALSESLTTT DGDTYEMAGV LPADIEMQDR YQALDHVELE ARADTVAATS GAHRRGHEFH YSAATLGSDA SFAFDMVRGD GIDGEHDGLT EYSTIGTYCH CHGESGAFDR LLAVPSKDI //