ID NU6M_BOSMU Reviewed; 175 AA. AC Q5ULB0; DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 07-DEC-2004, sequence version 1. DT 11-DEC-2019, entry version 45. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6; DE EC=7.1.1.2; DE AltName: Full=NADH dehydrogenase subunit 6; GN Name=MT-ND6; Synonyms=MTND6, NADH6, ND6; OS Bos mutus grunniens (Wild yak) (Bos grunniens). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=30521; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Gu Z., Zhao X., Li N., Wu C.; RT "Complete sequence of the Yak (Bos grunniens.) mitochondrial genome and its RT genetic relationship with related species."; RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) that is believed to belong to the CC minimal assembly required for catalysis. Complex I functions in the CC transfer of electrons from NADH to the respiratory chain. The immediate CC electron acceptor for the enzyme is believed to be ubiquinone (By CC similarity). {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass CC membrane protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY684273; AAV37053.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6. DR Pfam; PF00499; Oxidored_q3; 1. PE 3: Inferred from homology; KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain; KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone. FT CHAIN 1..175 FT /note="NADH-ubiquinone oxidoreductase chain 6" FT /id="PRO_0000253524" FT TRANSMEM 1..21 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 25..45 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 47..67 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 88..108 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 149..169 FT /note="Helical" FT /evidence="ECO:0000255" SQ SEQUENCE 175 AA; 19162 MW; 46B8CA091F06738D CRC64; MMLYIVFILS VIFVIGFVGF SSKPSPIYGG LGLIVSGGVG CGIVLNFGGS FLGLMVFLIY LGGMMVVFGY TTAMATEQYP EIWLLNKAVL GAFITALLME FFMVYYVLKD KEVEIVFEFN GLGDWVIYDT GDSGFFSEEA MGIAALYSYG TWLVIVTGWS LFIGVVVIME ITRGN //