ID NU6M_BOSMU Reviewed; 175 AA. AC Q5ULB0; DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 07-DEC-2004, sequence version 1. DT 22-SEP-2009, entry version 26. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6; DE EC=1.6.5.3; DE AltName: Full=NADH dehydrogenase subunit 6; GN Name=MT-ND6; Synonyms=MTND6, NADH6, ND6; OS Bos mutus grunniens (Wild yak) (Bos grunniens). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=30521; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Gu Z., Zhao X., Li N., Wu C.; RT "Complete sequence of the Yak (Bos grunniens.) mitochondrial genome RT and its genetic relationship with related species."; RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone (By similarity). CC -!- CATALYTIC ACTIVITY: NADH + ubiquinone = NAD(+) + ubiquinol. CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane CC protein (Potential). CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY684273; AAV37053.1; -; Genomic_DNA. DR HOVERGEN; Q5ULB0; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:EC. DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. DR GO; GO:0006810; P:transport; IEA:UniProtKB-KW. DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6. DR Pfam; PF00499; Oxidored_q3; 1. PE 3: Inferred from homology; KW Electron transport; Membrane; Mitochondrion; NAD; Oxidoreductase; KW Respiratory chain; Transmembrane; Transport; Ubiquinone. FT CHAIN 1 175 NADH-ubiquinone oxidoreductase chain 6. FT /FTId=PRO_0000253524. FT TRANSMEM 1 21 Potential. FT TRANSMEM 25 45 Potential. FT TRANSMEM 47 67 Potential. FT TRANSMEM 88 108 Potential. FT TRANSMEM 149 169 Potential. SQ SEQUENCE 175 AA; 19162 MW; 46B8CA091F06738D CRC64; MMLYIVFILS VIFVIGFVGF SSKPSPIYGG LGLIVSGGVG CGIVLNFGGS FLGLMVFLIY LGGMMVVFGY TTAMATEQYP EIWLLNKAVL GAFITALLME FFMVYYVLKD KEVEIVFEFN GLGDWVIYDT GDSGFFSEEA MGIAALYSYG TWLVIVTGWS LFIGVVVIME ITRGN //