ID   TNF15_MOUSE             Reviewed;         252 AA.
AC   Q5UBV8; Q8K3Y8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   22-JUL-2015, entry version 57.
DE   RecName: Full=Tumor necrosis factor ligand superfamily member 15;
DE   AltName: Full=TNF ligand-related molecule 1;
DE   AltName: Full=Vascular endothelial cell growth inhibitor;
GN   Name=Tnfsf15; Synonyms=Tl1, Vegi;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   STRAIN=BALB/c; TISSUE=Kidney;
RX   PubMed=11911831; DOI=10.1016/S1074-7613(02)00283-2;
RA   Migone T.-S., Zhang J., Luo X., Zhuang L., Chen C., Hu B., Hong J.S.,
RA   Perry J.W., Chen S.-F., Zhou J.X.H., Cho Y.H., Ullrich S.,
RA   Kanakaraj P., Carrell J., Boyd E., Olsen H.S., Hu G., Pukac L.,
RA   Liu D., Ni J., Kim S., Gentz R., Feng P., Moore P.A., Ruben S.M.,
RA   Wei P.;
RT   "TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T
RT   cell costimulator.";
RL   Immunity 16:479-492(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RC   STRAIN=C57BL/6;
RX   PubMed=15702971; DOI=10.1042/BJ20041739;
RA   Xiao Q., Hsu C.Y., Chen H., Ma X., Xu J., Lee J.-M.;
RT   "Characterization of cis-regulatory elements of the vascular
RT   endothelial growth inhibitor gene promoter.";
RL   Biochem. J. 388:913-920(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C3H/He; TISSUE=Osteoblast;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation
CC       of NF-kappa-B. Inhibits vascular endothelial growth and
CC       angiogenesis (in vitro). Promotes activation of caspases and
CC       apoptosis (By similarity). Promotes splenocyte alloactivation.
CC       {ECO:0000250, ECO:0000269|PubMed:11911831}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- INDUCTION: Up-regulated by TNF-alpha.
CC       {ECO:0000269|PubMed:15702971}.
CC   -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC       {ECO:0000305}.
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DR   EMBL; AF520786; AAM77367.1; -; mRNA.
DR   EMBL; AY764130; AAV33431.1; -; mRNA.
DR   EMBL; BC096494; AAH96494.1; -; mRNA.
DR   RefSeq; NP_796345.3; NM_177371.3.
DR   UniGene; Mm.208152; -.
DR   ProteinModelPortal; Q5UBV8; -.
DR   SMR; Q5UBV8; 95-252.
DR   STRING; 10090.ENSMUSP00000050144; -.
DR   PRIDE; Q5UBV8; -.
DR   GeneID; 326623; -.
DR   KEGG; mmu:326623; -.
DR   CTD; 9966; -.
DR   MGI; MGI:2180140; Tnfsf15.
DR   eggNOG; NOG40368; -.
DR   HOGENOM; HOG000060140; -.
DR   HOVERGEN; HBG067254; -.
DR   InParanoid; Q5UBV8; -.
DR   KO; K05478; -.
DR   PhylomeDB; Q5UBV8; -.
DR   NextBio; 397918; -.
DR   PRO; PR:Q5UBV8; -.
DR   Proteomes; UP000000589; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:MGI.
DR   GO; GO:0007250; P:activation of NF-kappaB-inducing kinase activity; ISO:MGI.
DR   GO; GO:0042107; P:cytokine metabolic process; ISO:MGI.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR006053; TNF.
DR   InterPro; IPR006052; TNF_dom.
DR   InterPro; IPR008064; TNFSF15.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   PANTHER; PTHR11471:SF24; PTHR11471:SF24; 1.
DR   Pfam; PF00229; TNF; 1.
DR   PRINTS; PR01234; TNECROSISFCT.
DR   SMART; SM00207; TNF; 1.
DR   SUPFAM; SSF49842; SSF49842; 1.
DR   PROSITE; PS50049; TNF_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Disulfide bond; Glycoprotein; Membrane;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN         1    252       Tumor necrosis factor ligand superfamily
FT                                member 15.
FT                                /FTId=PRO_0000333232.
FT   TOPO_DOM      1     39       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     40     60       Helical; Signal-anchor for type II
FT                                membrane protein. {ECO:0000255}.
FT   TOPO_DOM     61    252       Extracellular. {ECO:0000255}.
FT   SITE        188    188       Important for binding TNFRSF6B.
FT                                {ECO:0000250}.
FT   SITE        191    191       Important for binding TNFRSF6B.
FT                                {ECO:0000250}.
FT   CARBOHYD    137    137       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    230    230       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID    163    203       {ECO:0000250}.
FT   CONFLICT    180    180       V -> M (in Ref. 2; AAV33431 and 3;
FT                                AAH96494). {ECO:0000305}.
FT   CONFLICT    218    218       M -> T (in Ref. 2; AAV33431 and 3;
FT                                AAH96494). {ECO:0000305}.
SQ   SEQUENCE   252 AA;  27723 MW;  BB901C9350119E0F CRC64;
     MAEELGLGFG EGVPVEVLPE GCRHRPEARA GLAARSKACL ALTCCLLSFP ILAGLSTLLM
     AGQLRVPGKD CMLRAITEER SEPSPQQVYS PPRGKPRAHL TIKKQTPAPH LKNQLSALHW
     EHDLGMAFTK NGMKYINKSL VIPESGDYFI YSQITFRGTT SVCGDISRGR RPNKPDSITV
     VITKVADSYP EPARLLTGSK SVCEISNNWF QSLYLGAMFS LEEGDRLMVN VSDISLVDYT
     KEDKTFFGAF LL
//