ID Q5U3D5_DANRE Unreviewed; 497 AA.
AC Q5U3D5;
DT 07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 07-DEC-2004, sequence version 1.
DT 08-NOV-2023, entry version 117.
DE SubName: Full=Cyp2j30 protein {ECO:0000313|EMBL:AAI64549.1};
DE SubName: Full=Cytochrome P450, family 2, subfamily J, polypeptide 30 {ECO:0000313|EMBL:AAH85592.1};
DE SubName: Full=Cytochrome P450, family 2, subfamily N, polypeptide 13 {ECO:0000313|RefSeq:NP_001007357.1};
GN Name=cyp2j30 {ECO:0000313|EMBL:AAH85592.1,
GN ECO:0000313|RefSeq:NP_001007357.1};
GN Synonyms=si:dkey-183n20.13 {ECO:0000313|RefSeq:NP_001007357.1},
GN zgc:103711 {ECO:0000313|RefSeq:NP_001007357.1};
GN OrderedLocusNames=cyp2n13 {ECO:0000313|RefSeq:NP_001007357.1,
GN ECO:0000313|ZFIN:ZDB-GENE-041001-158};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH85592.1};
RN [1] {ECO:0000313|EMBL:AAH85592.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver {ECO:0000313|EMBL:AAH85592.1}, and PCR rescue
RC {ECO:0000313|EMBL:AAI64549.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001007357.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21087487;
RA Goldstone J.V., McArthur A.G., Kubota A., Zanette J., Parente T.,
RA Jonsson M.E., Nelson D.R., Stegeman J.J.;
RT "Identification and developmental expression of the full complement of
RT Cytochrome P450 genes in Zebrafish.";
RL BMC Genomics 11:643-643(2010).
RN [3] {ECO:0000313|RefSeq:NP_001007357.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21116621;
RA Kirischian N., McArthur A.G., Jesuthasan C., Krattenmacher B., Wilson J.Y.;
RT "Phylogenetic and functional analysis of the vertebrate cytochrome p450 2
RT family.";
RL J. Mol. Evol. 72:56-71(2011).
RN [4] {ECO:0000313|RefSeq:NP_001007357.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21445457;
RA Li Z.H., Alex D., Siu S.O., Chu I.K., Renn J., Winkler C., Lou S.,
RA Tsui S.K., Zhao H.Y., Yan W.R., Mahady G.B., Li G.H., Kwan Y.W., Wang Y.T.,
RA Lee S.M.;
RT "Combined in vivo imaging and omics approaches reveal metabolism of
RT icaritin and its glycosides in zebrafish larvae.";
RL Mol. Biosyst. 7:2128-2138(2011).
RN [5] {ECO:0000313|RefSeq:NP_001007357.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22697906;
RA Warner C.M., Gust K.A., Stanley J.K., Habib T., Wilbanks M.S.,
RA Garcia-Reyero N., Perkins E.J.;
RT "A systems toxicology approach to elucidate the mechanisms involved in RDX
RT species-specific sensitivity.";
RL Environ. Sci. Technol. 46:7790-7798(2012).
RN [6] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [7] {ECO:0000313|RefSeq:NP_001007357.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [8] {ECO:0000313|RefSeq:NP_001007357.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [9] {ECO:0000313|RefSeq:NP_001007357.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28411468;
RA Puthumana J., Kim B.M., Jeong C.B., Kim D.H., Kang H.M., Jung J.H.,
RA Kim I.C., Hwang U.K., Lee J.S.;
RT "Nine co-localized cytochrome P450 genes of the CYP2N, CYP2AD, and CYP2P
RT gene families in the mangrove killifish Kryptolebias marmoratus genome:
RT Identification and expression in response to B[alpha]P, BPA, OP, and NP.";
RL Aquat. Toxicol. 187:132-140(2017).
RN [10] {ECO:0000313|RefSeq:NP_001007357.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [11] {ECO:0000313|RefSeq:NP_001007357.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28069987;
RA Poon K.L., Wang X., Lee S.G., Ng A.S., Goh W.H., Zhao Z., Al-Haddawi M.,
RA Wang H., Mathavan S., Ingham P.W., McGinnis C., Carney T.J.;
RT "Editor's Highlight: Transgenic Zebrafish Reporter Lines as Alternative In
RT Vivo Organ Toxicity Models.";
RL Toxicol. Sci. 156:133-148(2017).
RN [12] {ECO:0000313|RefSeq:NP_001007357.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30290360;
RA Wang Z., Li G., Wu Q., Liu C., Shen J., Yan W.;
RT "Microcystin-LR exposure induced nephrotoxicity by triggering apoptosis in
RT female zebrafish.";
RL Chemosphere 214:598-605(2019).
RN [13] {ECO:0000313|RefSeq:NP_001007357.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; BC085592; AAH85592.1; -; mRNA.
DR EMBL; BC164549; AAI64549.1; -; mRNA.
DR RefSeq; NP_001007357.1; NM_001007356.1.
DR GeneID; 492484; -.
DR KEGG; dre:492484; -.
DR CTD; 492484; -.
DR ZFIN; ZDB-GENE-041001-158; cyp2n13.
DR OrthoDB; 2900138at2759; -.
DR Proteomes; UP000000437; Chromosome 20.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IBA:GO_Central.
DR GO; GO:0006082; P:organic acid metabolic process; IBA:GO_Central.
DR GO; GO:0006805; P:xenobiotic metabolic process; IBA:GO_Central.
DR CDD; cd11026; CYP2; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24300:SF177; CYTOCHROME P450 2J2; 1.
DR PANTHER; PTHR24300; CYTOCHROME P450 508A4-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 2: Evidence at transcript level;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
SQ SEQUENCE 497 AA; 56631 MW; C2716931A5C8F35C CRC64;
MAYTAMLETL DVKGILLFMV AFLLVADYLK NKNPPKYPPS PFSVPLLGNI FNVDSKEPHL
YLTKLGHAYN NIFSLRLGSD KTVFITGYKM VKEALVTQAE NFVDRPNSPV LARVYSGNAG
LFFSNGEMWK KQRRFALSTL RNFGLGKKTM ELAICEESRF LLEEIDEQKG AAFDPTILLY
NAVSNIICQM VFGQRFDYAD HQFKTMLKYI SKSIQLEGSV WGQIYEAFPA IMKHLPGPHN
DIFSNYDLLK SFVHEVIVKH KAKLDPSEPR DYIDTFLIEM KEKPLERVNG FEEPNLVACV
LDLFLAGTES TSNTLCWGLI YLIMYPDVQE KVQEEIDRVI GNSREPSIAD KPNMPYTEAV
IHEIMRFGDV IPLNGLRVAA RDTTLGECFI PKGTTVLPIL HSVLFDENEW ETPYKFNPGH
FLDKEGKFVR RDAFMPFSAG KRVCLGEQIA RIELFLFFVS LFRKFRFSAT EGEKLNMDGV
IGITRTPHPF KICATAR
//