ID LCE3A_HUMAN Reviewed; 89 AA. AC Q5TA76; DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot. DT 21-DEC-2004, sequence version 1. DT 24-JAN-2024, entry version 106. DE RecName: Full=Late cornified envelope protein 3A {ECO:0000303|PubMed:15854049}; DE AltName: Full=Late envelope protein 13 {ECO:0000303|PubMed:15854049}; GN Name=LCE3A {ECO:0000303|PubMed:15854049, ECO:0000312|HGNC:HGNC:29461}; GN Synonyms=LEP13 {ECO:0000303|PubMed:15854049}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [2] RP NOMENCLATURE, AND TISSUE SPECIFICITY. RX PubMed=15854049; DOI=10.1111/j.0022-202x.2005.23699.x; RA Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G., RA Byrne C.; RT "Late cornified envelope family in differentiating epithelia -- response to RT calcium and ultraviolet irradiation."; RL J. Invest. Dermatol. 124:1062-1070(2005). RN [3] RP FUNCTION, AND INDUCTION. RX PubMed=28634035; DOI=10.1016/j.jid.2017.06.003; RA Niehues H., Tsoi L.C., van der Krieken D.A., Jansen P.A.M., RA Oortveld M.A.W., Rodijk-Olthuis D., van Vlijmen I.M.J.J., RA Hendriks W.J.A.J., Helder R.W., Bouwstra J.A., van den Bogaard E.H., RA Stuart P.E., Nair R.P., Elder J.T., Zeeuwen P.L.J.M., Schalkwijk J.; RT "Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have RT Antibacterial Activity."; RL J. Invest. Dermatol. 137:2380-2388(2017). RN [4] RP INTERACTION WITH CYSRT1. RX PubMed=36804407; DOI=10.1016/j.jid.2023.01.022; RA Niehues H., Rikken G., Kersten F.F.J., Eeftens J.M., RA van Vlijmen-Willems I.M.J.J., Rodijk-Olthuis D., Jansen P.A.M., RA Hendriks W.J.A.J., Ederveen T.H.A., Schalkwijk J., van den Bogaard E.H., RA Zeeuwen P.L.J.M.; RT "CYSRT1: An Antimicrobial Epidermal Protein that Can Interact with Late RT Cornified Envelope Proteins."; RL J. Invest. Dermatol. 143:j.jid.2023.01.022-j.jid.2023.01.022(2023). CC -!- FUNCTION: A structural component of the cornified envelope of the CC stratum corneum involved in innate cutaneous host defense (Probable). CC Possesses defensin-like antimicrobial activity against a broad spectrum CC of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic CC species. Upon inflammation, may regulate skin barrier repair by shaping CC cutaneous microbiota composition and immune response to bacterial CC antigens (PubMed:28634035). {ECO:0000269|PubMed:28634035, CC ECO:0000305|PubMed:28634035}. CC -!- SUBUNIT: Interacts with CYSRT1; the interaction is direct. CC {ECO:0000269|PubMed:36804407}. CC -!- INTERACTION: CC Q5TA76; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-9394625, EBI-10173507; CC Q5TA76; P05187: ALPP; NbExp=5; IntAct=EBI-9394625, EBI-1211484; CC Q5TA76; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-9394625, EBI-741528; CC Q5TA76; A8MQ03: CYSRT1; NbExp=9; IntAct=EBI-9394625, EBI-3867333; CC Q5TA76; Q12805: EFEMP1; NbExp=3; IntAct=EBI-9394625, EBI-536772; CC Q5TA76; O95967: EFEMP2; NbExp=3; IntAct=EBI-9394625, EBI-743414; CC Q5TA76; P23142-4: FBLN1; NbExp=3; IntAct=EBI-9394625, EBI-11956479; CC Q5TA76; Q8IUG1: KRTAP1-3; NbExp=5; IntAct=EBI-9394625, EBI-11749135; CC Q5TA76; Q9BYS1: KRTAP1-5; NbExp=4; IntAct=EBI-9394625, EBI-11741292; CC Q5TA76; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-9394625, EBI-10172290; CC Q5TA76; P60410: KRTAP10-8; NbExp=5; IntAct=EBI-9394625, EBI-10171774; CC Q5TA76; P60411: KRTAP10-9; NbExp=5; IntAct=EBI-9394625, EBI-10172052; CC Q5TA76; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-9394625, EBI-1052037; CC Q5TA76; P60328: KRTAP12-3; NbExp=6; IntAct=EBI-9394625, EBI-11953334; CC Q5TA76; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-9394625, EBI-10176396; CC Q5TA76; Q9BYP8: KRTAP17-1; NbExp=5; IntAct=EBI-9394625, EBI-11988175; CC Q5TA76; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-9394625, EBI-14065470; CC Q5TA76; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-9394625, EBI-9996449; CC Q5TA76; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-9394625, EBI-751260; CC Q5TA76; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-9394625, EBI-3957694; CC Q5TA76; Q9BYQ7: KRTAP4-1; NbExp=3; IntAct=EBI-9394625, EBI-34579671; CC Q5TA76; Q9BYQ6: KRTAP4-11; NbExp=5; IntAct=EBI-9394625, EBI-10302392; CC Q5TA76; Q9BQ66: KRTAP4-12; NbExp=8; IntAct=EBI-9394625, EBI-739863; CC Q5TA76; Q9BYR5: KRTAP4-2; NbExp=4; IntAct=EBI-9394625, EBI-10172511; CC Q5TA76; Q9BYR3: KRTAP4-4; NbExp=5; IntAct=EBI-9394625, EBI-11958132; CC Q5TA76; Q9BYR2: KRTAP4-5; NbExp=5; IntAct=EBI-9394625, EBI-11993254; CC Q5TA76; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-9394625, EBI-11993296; CC Q5TA76; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-9394625, EBI-11958178; CC Q5TA76; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-9394625, EBI-11974251; CC Q5TA76; Q6L8H1: KRTAP5-4; NbExp=5; IntAct=EBI-9394625, EBI-11963072; CC Q5TA76; Q6L8G9: KRTAP5-6; NbExp=6; IntAct=EBI-9394625, EBI-10250562; CC Q5TA76; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-9394625, EBI-11987425; CC Q5TA76; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-9394625, EBI-3958099; CC Q5TA76; Q9BYQ4: KRTAP9-2; NbExp=8; IntAct=EBI-9394625, EBI-1044640; CC Q5TA76; Q9BYQ3: KRTAP9-3; NbExp=8; IntAct=EBI-9394625, EBI-1043191; CC Q5TA76; Q9BYQ0: KRTAP9-8; NbExp=5; IntAct=EBI-9394625, EBI-11958364; CC Q5TA76; Q5T751: LCE1C; NbExp=3; IntAct=EBI-9394625, EBI-12224199; CC Q5TA76; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-9394625, EBI-10246607; CC Q5TA76; O14633: LCE2B; NbExp=3; IntAct=EBI-9394625, EBI-11478468; CC Q5TA76; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-9394625, EBI-11973993; CC Q5TA76; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-9394625, EBI-11974495; CC Q5TA76; P80188: LCN2; NbExp=3; IntAct=EBI-9394625, EBI-11911016; CC Q5TA76; Q8N5G2: MACO1; NbExp=3; IntAct=EBI-9394625, EBI-2683507; CC Q5TA76; Q99750: MDFI; NbExp=5; IntAct=EBI-9394625, EBI-724076; CC Q5TA76; O96009: NAPSA; NbExp=3; IntAct=EBI-9394625, EBI-7196415; CC Q5TA76; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-9394625, EBI-22310682; CC Q5TA76; Q8WWZ8: OIT3; NbExp=3; IntAct=EBI-9394625, EBI-10277776; CC Q5TA76; Q9NRY7: PLSCR2; NbExp=3; IntAct=EBI-9394625, EBI-3937430; CC Q5TA76; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-9394625, EBI-3918154; CC Q5TA76; O76081-6: RGS20; NbExp=3; IntAct=EBI-9394625, EBI-10178530; CC Q5TA76; P49901: SMCP; NbExp=3; IntAct=EBI-9394625, EBI-750494; CC Q5TA76; O43609: SPRY1; NbExp=6; IntAct=EBI-9394625, EBI-3866665; CC Q5TA76; O43610: SPRY3; NbExp=3; IntAct=EBI-9394625, EBI-12290641; CC Q5TA76; P01137: TGFB1; NbExp=3; IntAct=EBI-9394625, EBI-779636; CC Q5TA76; P22735: TGM1; NbExp=3; IntAct=EBI-9394625, EBI-2562368; CC Q5TA76; Q8IWZ5: TRIM42; NbExp=5; IntAct=EBI-9394625, EBI-5235829; CC Q5TA76; O14817: TSPAN4; NbExp=3; IntAct=EBI-9394625, EBI-8652667; CC Q5TA76; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-9394625, EBI-11957238; CC Q5TA76; B2RUY7: VWC2L; NbExp=6; IntAct=EBI-9394625, EBI-11747707; CC -!- TISSUE SPECIFICITY: Skin-specific. Expression was readily detected in CC adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, CC esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, CC or placenta. {ECO:0000269|PubMed:15854049}. CC -!- INDUCTION: Induced upon stimulation with inflammatory cytokines CC produced by T-helper 1 cells (IL1A, TNF, IFNG) and T-helper 17 cells CC (IL17A, IL22). {ECO:0000269|PubMed:28634035}. CC -!- SIMILARITY: Belongs to the LCE family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL139247; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR CCDS; CCDS1017.1; -. DR RefSeq; NP_848518.1; NM_178431.1. DR AlphaFoldDB; Q5TA76; -. DR BioGRID; 131648; 62. DR IntAct; Q5TA76; 60. DR STRING; 9606.ENSP00000335006; -. DR iPTMnet; Q5TA76; -. DR PhosphoSitePlus; Q5TA76; -. DR BioMuta; LCE3A; -. DR DMDM; 74745783; -. DR MassIVE; Q5TA76; -. DR PaxDb; 9606-ENSP00000335006; -. DR PeptideAtlas; Q5TA76; -. DR Antibodypedia; 82212; 2 antibodies from 1 providers. DR DNASU; 353142; -. DR Ensembl; ENST00000335674.1; ENSP00000335006.1; ENSG00000185962.1. DR GeneID; 353142; -. DR KEGG; hsa:353142; -. DR MANE-Select; ENST00000335674.1; ENSP00000335006.1; NM_178431.1; NP_848518.1. DR UCSC; uc010pdt.2; human. DR AGR; HGNC:29461; -. DR CTD; 353142; -. DR DisGeNET; 353142; -. DR GeneCards; LCE3A; -. DR HGNC; HGNC:29461; LCE3A. DR HPA; ENSG00000185962; Tissue enriched (lymphoid). DR MIM; 612613; gene. DR neXtProt; NX_Q5TA76; -. DR OpenTargets; ENSG00000185962; -. DR PharmGKB; PA134880553; -. DR VEuPathDB; HostDB:ENSG00000185962; -. DR eggNOG; ENOG502TDZ9; Eukaryota. DR GeneTree; ENSGT00940000163498; -. DR HOGENOM; CLU_152038_1_0_1; -. DR InParanoid; Q5TA76; -. DR OMA; CHRSHRC; -. DR PathwayCommons; Q5TA76; -. DR Reactome; R-HSA-6809371; Formation of the cornified envelope. DR SignaLink; Q5TA76; -. DR BioGRID-ORCS; 353142; 18 hits in 1136 CRISPR screens. DR GenomeRNAi; 353142; -. DR Pharos; Q5TA76; Tbio. DR PRO; PR:Q5TA76; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q5TA76; Protein. DR Bgee; ENSG00000185962; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 46 other cell types or tissues. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB. DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB. DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW. DR GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB. DR InterPro; IPR028205; LCE. DR Pfam; PF14672; LCE; 1. PE 1: Evidence at protein level; KW Antimicrobial; Keratinization; Reference proteome. FT CHAIN 1..89 FT /note="Late cornified envelope protein 3A" FT /id="PRO_0000235333" FT REGION 1..46 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 62..89 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 24..43 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 64..89 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VARIANT 59 FT /note="R -> C (in dbSNP:rs16834245)" FT /id="VAR_053484" SQ SEQUENCE 89 AA; 9146 MW; 5E53A9A5739ABA84 CRC64; MSCQQNQQQC QPPPKCPAKS PAQCLPPASS SCAPSSGGCG PSSERSCCLS HHRCRRSHRC RCQSSNSCDR GSGQQGGSSS CGHSSAGCC //