ID Q5T5P1_HUMAN Unreviewed; 933 AA. AC Q5T5P1; DT 21-DEC-2004, integrated into UniProtKB/TrEMBL. DT 21-AUG-2007, sequence version 2. DT 29-MAY-2024, entry version 120. DE SubName: Full=KIAA1217 {ECO:0000313|Ensembl:ENSP00000365639.4}; DE Flags: Fragment; GN Name=KIAA1217 {ECO:0000313|Ensembl:ENSP00000365639.4}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000365639.4, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000365639.4, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., RA Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [2] {ECO:0007829|PubMed:15951569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=15951569; DOI=10.1074/mcp.M500089-MCP200; RA Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J., RA Lauffenburger D.A., White F.M.; RT "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the RT epidermal growth factor receptor signaling network reveals dynamic RT modules."; RL Mol. Cell. Proteomics 4:1240-1250(2005). RN [3] {ECO:0007829|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [4] {ECO:0007829|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [5] {ECO:0000313|Ensembl:ENSP00000365639.4} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2024) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC063961; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL157781; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL353583; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL353650; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL355977; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL356113; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL356477; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL391499; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL392104; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; Q5T5P1; -. DR SMR; Q5T5P1; -. DR MassIVE; Q5T5P1; -. DR MaxQB; Q5T5P1; -. DR PeptideAtlas; Q5T5P1; -. DR ProteomicsDB; 64536; -. DR Antibodypedia; 1578; 44 antibodies from 15 providers. DR Ensembl; ENST00000376456.8; ENSP00000365639.4; ENSG00000120549.19. DR UCSC; uc057sgy.1; human. DR HGNC; HGNC:25428; KIAA1217. DR VEuPathDB; HostDB:ENSG00000120549; -. DR GeneTree; ENSGT00940000156098; -. DR HOGENOM; CLU_002507_2_0_1; -. DR ChiTaRS; KIAA1217; human. DR Proteomes; UP000005640; Chromosome 10. DR Bgee; ENSG00000120549; Expressed in epithelial cell of pancreas and 188 other cell types or tissues. DR ExpressionAtlas; Q5T5P1; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter. DR Gene3D; 1.20.58.1540; Actin interacting protein 3, C-terminal domain; 1. DR InterPro; IPR022782; AIP3-like_C. DR PANTHER; PTHR22741; P140CAP/SNIP-RELATED; 1. DR PANTHER; PTHR22741:SF11; SICKLE TAIL PROTEIN HOMOLOG; 1. DR Pfam; PF03915; AIP3; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}; KW Proteomics identification {ECO:0007829|EPD:Q5T5P1, KW ECO:0007829|MaxQB:Q5T5P1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 188..269 FT /note="Actin interacting protein 3-like C-terminal" FT /evidence="ECO:0000259|Pfam:PF03915" FT REGION 1..79 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 112..177 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 290..331 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 456..476 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 491..510 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 813..838 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 611..648 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 34..48 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 49..64 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 162..177 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 300..327 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 933 FT /evidence="ECO:0000313|Ensembl:ENSP00000365639.4" SQ SEQUENCE 933 AA; 103666 MW; 5D1C4D1B91D13D56 CRC64; MEENESQKCE PCLPYSADRR QMQEQGKGNL HVTSPEDAEC RRTKERLSNG NSRGSVSKSS RNIPRRHTLG GPRSSKEILG MQTSEMDRKR EAFLEHLKQK YPHHASAIMG HQERLRDQTR SPKLSHSPQP PSLGDPVEHL SETSADSLEA MSEGDAPTPF SRGSRTRASL PVVRSTNQTK ERSLGVLYLQ YGDETKQLRM PNEITSADTI RALFVSAFPQ QLTMKMLESP SVAIYIKDES RNVYYELNDV RNIQDRSLLK VYNKDPAHAF NHTPKTMNGD MRMQRELVYA RGDGPGAPRP GSTAHPPHAI PNSPPSTPVP HSMPPSPSRI PYGGTRSMVV PGNATIPRDR ISSLPVSRPI SPSPSAILER RDVKPDEDMS GKNIAMYRNE GFYADPYLYH EGRMSIASSH GGHPLDVPDH IIAYHRTAIR SASAYCNPSM QAEMHMEQSL YRQKSRKYPD SHLPTLGSKT PPASPHRVSD LRMIDMHAHY NAHGPPHTMQ PDRASPSRQA FKKEPGTLVY IEKPRSAAGL SSLVDLGPPL MEKQVFAYST ATIPKDRETS EKMMKTTANR NHTDSAGTPH VSGGKMLSAL ESTVPPSQPP PVGTSAIHMS LLEMRRSVAE LRLQLQQMRQ LQLQNQELLR AMMKKAELEI SGKVMETMKR LEDPVQRQRV LVEQERQKYL HEEEKIVKKL CELEDFVEDL KKDSTAASRL VTLKDVEDGA FLLRQVGEAV ATLKGEFPTL QNKMRAILRI EVEAVRFLKE EPHKLDSLLK RVRSMTDVLT MLRRHVTDGL LKGTDAAQAA QYMAMEKATA AEVLKSQEEA AHTSGQPFHS TGAPGDAKSE VVPLSGMMVR HAQSSPVVIQ PSQHSVALLN PAQNLPHVAS SPAVPQEATS TLQMSQAPQS PQIPMNGSAM QSLFIEEIHS VSAKNRAVSI EKA //