ID Q5SWU0_MOUSE Unreviewed; 428 AA. AC Q5SWU0; DT 21-DEC-2004, integrated into UniProtKB/TrEMBL. DT 21-DEC-2004, sequence version 1. DT 09-DEC-2015, entry version 96. DE SubName: Full=DNA-binding protein Ikaros {ECO:0000313|Ensembl:ENSMUSP00000018798}; DE SubName: Full=IKAROS family zinc finger 1 {ECO:0000313|EMBL:AAI38790.1}; DE SubName: Full=Zinc finger protein, subfamily 1A, 1 (Ikaros), isoform CRA_b {ECO:0000313|EMBL:EDL40640.1}; GN Name=Ikzf1 {ECO:0000313|EMBL:AAI38790.1, GN ECO:0000313|Ensembl:ENSMUSP00000018798, ECO:0000313|MGI:MGI:1342540}; GN Synonyms=Zfpn1a1 {ECO:0000313|EMBL:EDL40640.1}; GN ORFNames=mCG_3994 {ECO:0000313|EMBL:EDL40640.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000018798, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|EMBL:EDL40640.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL40640.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [2] {ECO:0000313|EMBL:AAI38790.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung {ECO:0000313|EMBL:AAI38790.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] {ECO:0000313|EMBL:EDL40640.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL40640.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSMUSP00000018798, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000018798, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [5] {ECO:0000313|Ensembl:ENSMUSP00000018798} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000018798}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL596450; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC138789; AAI38790.1; -; mRNA. DR EMBL; CH466574; EDL40640.1; -; Genomic_DNA. DR EMBL; CH466574; EDL40643.1; -; Genomic_DNA. DR RefSeq; NP_001288794.1; NM_001301865.1. DR RefSeq; NP_033604.2; NM_009578.3. DR RefSeq; XP_011242017.1; XM_011243715.1. DR UniGene; Mm.103545; -. DR STRING; 10090.ENSMUSP00000075992; -. DR Ensembl; ENSMUST00000018798; ENSMUSP00000018798; ENSMUSG00000018654. DR GeneID; 22778; -. DR UCSC; uc007ial.2; mouse. DR CTD; 10320; -. DR MGI; MGI:1342540; Ikzf1. DR eggNOG; COG5048; LUCA. DR eggNOG; KOG1721; Eukaryota. DR GeneTree; ENSGT00550000074392; -. DR HOVERGEN; HBG004752; -. DR TreeFam; TF331189; -. DR NextBio; 303333; -. DR Proteomes; UP000000589; Chromosome 11. DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0005721; C:pericentric heterochromatin; IDA:MGI. DR GO; GO:0043234; C:protein complex; ISO:MGI. DR GO; GO:0032993; C:protein-DNA complex; IDA:MGI. DR GO; GO:0005667; C:transcription factor complex; TAS:MGI. DR GO; GO:0003677; F:DNA binding; IDA:MGI. DR GO; GO:0046872; F:metal ion binding; IEA:InterPro. DR GO; GO:0008187; F:poly-pyrimidine tract binding; IDA:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; IPI:MGI. DR GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IDA:MGI. DR GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IDA:MGI. DR GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:NTNU_SB. DR GO; GO:0043565; F:sequence-specific DNA binding; IMP:MGI. DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:MGI. DR GO; GO:0001227; F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding; IDA:NTNU_SB. DR GO; GO:0035881; P:amacrine cell differentiation; IDA:MGI. DR GO; GO:0030183; P:B cell differentiation; IMP:MGI. DR GO; GO:0030218; P:erythrocyte differentiation; ISO:MGI. DR GO; GO:0045184; P:establishment of protein localization; IMP:MGI. DR GO; GO:0030900; P:forebrain development; IMP:MGI. DR GO; GO:0048732; P:gland development; IMP:MGI. DR GO; GO:0030097; P:hemopoiesis; IMP:MGI. DR GO; GO:0048535; P:lymph node development; IMP:MGI. DR GO; GO:0030098; P:lymphocyte differentiation; ISO:MGI. DR GO; GO:0001779; P:natural killer cell differentiation; IMP:MGI. DR GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:NTNU_SB. DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:MGI. DR GO; GO:0048541; P:Peyer's patch development; IMP:MGI. DR GO; GO:0045579; P:positive regulation of B cell differentiation; IMP:MGI. DR GO; GO:0010628; P:positive regulation of gene expression; IMP:MGI. DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI. DR GO; GO:0045660; P:positive regulation of neutrophil differentiation; IMP:MGI. DR GO; GO:0051138; P:positive regulation of NK T cell differentiation; IMP:MGI. DR GO; GO:0045899; P:positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; IMP:MGI. DR GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IMP:MGI. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:MGI. DR GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:MGI. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:MGI. DR GO; GO:0060041; P:retina development in camera-type eye; IMP:MGI. DR GO; GO:0060040; P:retinal bipolar neuron differentiation; IDA:MGI. DR GO; GO:0030217; P:T cell differentiation; IMP:MGI. DR GO; GO:0048538; P:thymus development; IMP:MGI. DR Gene3D; 3.30.160.60; -; 3. DR InterPro; IPR007087; Znf_C2H2. DR InterPro; IPR015880; Znf_C2H2-like. DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd. DR Pfam; PF00096; zf-C2H2; 1. DR SMART; SM00355; ZnF_C2H2; 5. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Proteomics identification {ECO:0000213|MaxQB:Q5SWU0, KW ECO:0000213|PeptideAtlas:Q5SWU0}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 58 85 C2H2-type. {ECO:0000259|PROSITE:PS50157}. FT DOMAIN 86 113 C2H2-type. {ECO:0000259|PROSITE:PS50157}. FT DOMAIN 114 142 C2H2-type. {ECO:0000259|PROSITE:PS50157}. FT COILED 337 357 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 428 AA; 47976 MW; 10C4CC7217FEE2EA CRC64; MDVDEGQDMS QVSGKESPPV SDTPDEGDEP MPVPEDLSTT SGAQQNSKSD RGMGERPFQC NQCGASFTQK GNLLRHIKLH SGEKPFKCHL CNYACRRRDA LTGHLRTHSV GKPHKCGYCG RSYKQRSSLE EHKERCHNYL ESMGLPGMYP VIKEETNHNE MAEDLCKIGA ERSLVLDRLA SNVAKRKSSM PQKFLGDKCL SDMPYDSANY EKEDMMTSHV MDQAINNAIN YLGAESLRPL VQTPPGSSEV VPVISSMYQL HKPPSDGPPR SNHSAQDAVD NLLLLSKAKS VSSEREASPS NSCQDSTDTE SNAEEQRSGL IYLTNHINPH ARNGLALKEE QRAYEVLRAA SENSQDAFRV VSTSGEQLKV YKCEHCRVLF LDHVMYTIHM GCHGFRDPFE CNMCGYHSQD RYEFSSHITR GEHRYHLS //