ID Q5SWU0_MOUSE Unreviewed; 428 AA. AC Q5SWU0; DT 21-DEC-2004, integrated into UniProtKB/TrEMBL. DT 21-DEC-2004, sequence version 1. DT 01-APR-2015, entry version 88. DE SubName: Full=DNA-binding protein Ikaros {ECO:0000313|Ensembl:ENSMUSP00000018798}; DE SubName: Full=IKAROS family zinc finger 1 {ECO:0000313|EMBL:AAI38790.1}; DE SubName: Full=Zinc finger protein, subfamily 1A, 1 (Ikaros), isoform CRA_b {ECO:0000313|EMBL:EDL40640.1}; GN Name=Ikzf1 {ECO:0000313|EMBL:AAI38790.1, GN ECO:0000313|Ensembl:ENSMUSP00000018798, ECO:0000313|MGI:MGI:1342540}; GN Synonyms=Zfpn1a1 {ECO:0000313|EMBL:EDL40640.1}; GN ORFNames=mCG_3994 {ECO:0000313|EMBL:EDL40640.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000018798, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|EMBL:EDL40640.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL40640.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [2] {ECO:0000313|EMBL:AAI38790.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung {ECO:0000313|EMBL:AAI38790.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] {ECO:0000313|EMBL:EDL40640.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL40640.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSMUSP00000018798, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000018798, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [5] {ECO:0000313|Ensembl:ENSMUSP00000018798} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000018798}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL596450; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC138789; AAI38790.1; -; mRNA. DR EMBL; CH466574; EDL40640.1; -; Genomic_DNA. DR EMBL; CH466574; EDL40643.1; -; Genomic_DNA. DR RefSeq; NP_001288794.1; NM_001301865.1. DR RefSeq; NP_033604.2; NM_009578.3. DR UniGene; Mm.103545; -. DR SMR; Q5SWU0; 27-133, 337-428. DR PRIDE; Q5SWU0; -. DR Ensembl; ENSMUST00000018798; ENSMUSP00000018798; ENSMUSG00000018654. DR GeneID; 22778; -. DR KEGG; mmu:22778; -. DR UCSC; uc007ial.1; mouse. DR CTD; 10320; -. DR MGI; MGI:1342540; Ikzf1. DR GeneTree; ENSGT00550000074392; -. DR HOVERGEN; HBG004752; -. DR KO; K09220; -. DR TreeFam; TF331189; -. DR NextBio; 303333; -. DR Proteomes; UP000000589; Chromosome 11. DR Bgee; Q5SWU0; -. DR ExpressionAtlas; Q5SWU0; baseline and differential. DR Genevestigator; Q5SWU0; -. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0005721; C:pericentric heterochromatin; IDA:MGI. DR GO; GO:0043234; C:protein complex; ISO:MGI. DR GO; GO:0005667; C:transcription factor complex; TAS:MGI. DR GO; GO:0003677; F:DNA binding; IDA:MGI. DR GO; GO:0046872; F:metal ion binding; IEA:InterPro. DR GO; GO:0046982; F:protein heterodimerization activity; IPI:MGI. DR GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:NTNU_SB. DR GO; GO:0001227; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IDA:NTNU_SB. DR GO; GO:0043565; F:sequence-specific DNA binding; IMP:MGI. DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI. DR GO; GO:0030183; P:B cell differentiation; IMP:MGI. DR GO; GO:0030900; P:forebrain development; IMP:MGI. DR GO; GO:0048732; P:gland development; IMP:MGI. DR GO; GO:0030097; P:hemopoiesis; IMP:MGI. DR GO; GO:0048535; P:lymph node development; IMP:MGI. DR GO; GO:0001779; P:natural killer cell differentiation; IMP:MGI. DR GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:NTNU_SB. DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:MGI. DR GO; GO:0048541; P:Peyer's patch development; IMP:MGI. DR GO; GO:0045579; P:positive regulation of B cell differentiation; IMP:MGI. DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI. DR GO; GO:0045660; P:positive regulation of neutrophil differentiation; IMP:MGI. DR GO; GO:0051138; P:positive regulation of NK T cell differentiation; IMP:MGI. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:MGI. DR GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:MGI. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:MGI. DR GO; GO:0060041; P:retina development in camera-type eye; IMP:MGI. DR GO; GO:0030217; P:T cell differentiation; IMP:MGI. DR GO; GO:0048538; P:thymus development; IMP:MGI. DR Gene3D; 3.30.160.60; -; 3. DR InterPro; IPR007087; Znf_C2H2. DR InterPro; IPR015880; Znf_C2H2-like. DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd. DR SMART; SM00355; ZnF_C2H2; 5. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. SQ SEQUENCE 428 AA; 47976 MW; 10C4CC7217FEE2EA CRC64; MDVDEGQDMS QVSGKESPPV SDTPDEGDEP MPVPEDLSTT SGAQQNSKSD RGMGERPFQC NQCGASFTQK GNLLRHIKLH SGEKPFKCHL CNYACRRRDA LTGHLRTHSV GKPHKCGYCG RSYKQRSSLE EHKERCHNYL ESMGLPGMYP VIKEETNHNE MAEDLCKIGA ERSLVLDRLA SNVAKRKSSM PQKFLGDKCL SDMPYDSANY EKEDMMTSHV MDQAINNAIN YLGAESLRPL VQTPPGSSEV VPVISSMYQL HKPPSDGPPR SNHSAQDAVD NLLLLSKAKS VSSEREASPS NSCQDSTDTE SNAEEQRSGL IYLTNHINPH ARNGLALKEE QRAYEVLRAA SENSQDAFRV VSTSGEQLKV YKCEHCRVLF LDHVMYTIHM GCHGFRDPFE CNMCGYHSQD RYEFSSHITR GEHRYHLS //