ID Q5SWU0_MOUSE Unreviewed; 428 AA. AC Q5SWU0; DT 21-DEC-2004, integrated into UniProtKB/TrEMBL. DT 21-DEC-2004, sequence version 1. DT 07-OCT-2020, entry version 130. DE SubName: Full=DNA-binding protein Ikaros {ECO:0000313|Ensembl:ENSMUSP00000018798}; DE SubName: Full=IKAROS family zinc finger 1 {ECO:0000313|EMBL:AAI38790.1}; GN Name=Ikzf1 {ECO:0000313|EMBL:AAI38790.1, GN ECO:0000313|Ensembl:ENSMUSP00000018798, ECO:0000313|MGI:MGI:1342540}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000018798, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|EMBL:AAI38790.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung {ECO:0000313|EMBL:AAI38790.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000018798, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000018798, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000018798} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000018798}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL596450; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC138789; AAI38790.1; -; mRNA. DR RefSeq; NP_001288794.1; NM_001301865.1. DR RefSeq; NP_033604.2; NM_009578.3. DR RefSeq; XP_011242017.1; XM_011243715.1. DR SMR; Q5SWU0; -. DR jPOST; Q5SWU0; -. DR MaxQB; Q5SWU0; -. DR Antibodypedia; 3980; 542 antibodies. DR Ensembl; ENSMUST00000018798; ENSMUSP00000018798; ENSMUSG00000018654. DR GeneID; 22778; -. DR UCSC; uc007ial.2; mouse. DR CTD; 10320; -. DR MGI; MGI:1342540; Ikzf1. DR GeneTree; ENSGT00940000156782; -. DR OrthoDB; 385551at2759; -. DR TreeFam; TF331189; -. DR BioGRID-ORCS; 22778; 2 hits in 19 CRISPR screens. DR ChiTaRS; Ikzf1; mouse. DR Proteomes; UP000000589; Chromosome 11. DR Bgee; ENSMUSG00000018654; Expressed in spleen and 167 other tissues. DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:NTNU_SB. DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:NTNU_SB. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR Pfam; PF00096; zf-C2H2; 3. DR SMART; SM00355; ZnF_C2H2; 5. DR SUPFAM; SSF57667; SSF57667; 3. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042}; KW Proteomics identification {ECO:0000213|EPD:Q5SWU0, KW ECO:0000213|MaxQB:Q5SWU0, ECO:0000213|PeptideAtlas:Q5SWU0}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042}; KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}. FT DOMAIN 58..85 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 86..113 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 114..142 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT REGION 1..55 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 290..314 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 337..357 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 37..52 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 428 AA; 47976 MW; 10C4CC7217FEE2EA CRC64; MDVDEGQDMS QVSGKESPPV SDTPDEGDEP MPVPEDLSTT SGAQQNSKSD RGMGERPFQC NQCGASFTQK GNLLRHIKLH SGEKPFKCHL CNYACRRRDA LTGHLRTHSV GKPHKCGYCG RSYKQRSSLE EHKERCHNYL ESMGLPGMYP VIKEETNHNE MAEDLCKIGA ERSLVLDRLA SNVAKRKSSM PQKFLGDKCL SDMPYDSANY EKEDMMTSHV MDQAINNAIN YLGAESLRPL VQTPPGSSEV VPVISSMYQL HKPPSDGPPR SNHSAQDAVD NLLLLSKAKS VSSEREASPS NSCQDSTDTE SNAEEQRSGL IYLTNHINPH ARNGLALKEE QRAYEVLRAA SENSQDAFRV VSTSGEQLKV YKCEHCRVLF LDHVMYTIHM GCHGFRDPFE CNMCGYHSQD RYEFSSHITR GEHRYHLS //