ID Q5SVI9_MOUSE Unreviewed; 479 AA. AC Q5SVI9; DT 21-DEC-2004, integrated into UniProtKB/TrEMBL. DT 21-DEC-2004, sequence version 1. DT 09-JAN-2007, entry version 23. DE Calcium/calmodulin-dependent protein kinase II, delta. GN Name=Camk2d; ORFNames=RP23-340E18.5-001; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RA Howden P.; RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE. RA Chapman J.; RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: CaM-kinase II (CAMK2) is a prominent kinase in the CC central nervous system that may function in long-term potentiation CC and neurotransmitter release. Member of the NMDAR signaling CC complex in excitatory synapses it may regulate NMDAR-dependent CC potentiation of the AMPAR and synaptic plasticity (By similarity). CC -!- SIMILARITY: Belongs to the Ser/Thr protein kinase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL645469; CAI25262.1; -; Genomic_DNA. DR EMBL; AL611926; CAI25262.1; JOINED; Genomic_DNA. DR EMBL; AL645469; CAI24952.1; JOINED; Genomic_DNA. DR EMBL; AL611926; CAI24952.1; -; Genomic_DNA. DR SMR; Q5SVI9; 8-315, 337-474. DR Ensembl; ENSMUSG00000057897; Mus musculus. DR ArrayExpress; Q5SVI9; -. DR RZPD-ProtExp; IOM16253; -. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW. DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW. DR GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro. DR InterPro; IPR013543; CaMKII_AD. DR InterPro; IPR011009; Kinase_like. DR InterPro; IPR000719; Prot_kinase. DR InterPro; IPR008271; Ser_thr_pkin_AS. DR InterPro; IPR002290; Ser_thr_pkinase. DR Pfam; PF08332; CaMKII_AD; 1. DR Pfam; PF00069; Pkinase; 1. DR ProDom; PD000001; Prot_kinase; 1. DR SMART; SM00220; S_TKc; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. KW ATP-binding; Kinase; Nucleotide-binding; KW Serine/threonine-protein kinase; Transferase. SQ SEQUENCE 479 AA; 54104 MW; 12F45B7A66AA83AD CRC64; MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL KGAILTTMLA TRNFSAAKSL LNKKADGVKE SSDSTNTTIE DEDAKARKQE IIKTTEQLIE AVNNGDFEAY AKICDPGLTS FEPEALGNLV EGMDFHRFYF ENLLAKNSKP IHTTILNPHV HVIGEDAACI AYIRLTQYID GQGRPRTSQS EETRVWHRRD GKWQNVHFHC SGAPVAPLQ //