ID Q5SUW3_MOUSE Unreviewed; 550 AA. AC Q5SUW3; DT 05-FEB-2008, integrated into UniProtKB/TrEMBL. DT 05-FEB-2008, sequence version 1. DT 27-NOV-2024, entry version 105. DE SubName: Full=Growth factor receptor bound protein 10 {ECO:0000313|Ensembl:ENSMUSP00000105280.2}; GN Name=Grb10 {ECO:0000313|Ensembl:ENSMUSP00000105280.2, GN ECO:0000313|MGI:MGI:103232}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000105280.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0007829|PubMed:15345747} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=15345747; DOI=10.1074/mcp.M400085-MCP200; RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; RT "Phosphoproteomic analysis of the developing mouse brain."; RL Mol. Cell. Proteomics 3:1093-1101(2004). RN [2] {ECO:0007829|PubMed:17242355} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=17242355; DOI=10.1073/pnas.0609836104; RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; RT "Large-scale phosphorylation analysis of mouse liver."; RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000105280.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000105280.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RG Mouse Genome Sequencing Consortium; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [5] {ECO:0000313|Ensembl:ENSMUSP00000105280.2} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000105280.2}; RX PubMed=21750661; RA Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., RA Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D., RA Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L., RA Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J., RA Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P., RA Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G., RA Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.; RT "Modernizing reference genome assemblies."; RL PLoS Biol. 9:e1001091-e1001091(2011). RN [6] {ECO:0000313|Ensembl:ENSMUSP00000105280.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000105280.2}; RG Ensembl; RL Submitted (AUG-2024) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; Q5SUW3; -. DR SMR; Q5SUW3; -. DR PeptideAtlas; Q5SUW3; -. DR Antibodypedia; 27751; 479 antibodies from 36 providers. DR Ensembl; ENSMUST00000109653.8; ENSMUSP00000105280.2; ENSMUSG00000020176.18. DR AGR; MGI:103232; -. DR MGI; MGI:103232; Grb10. DR VEuPathDB; HostDB:ENSMUSG00000020176; -. DR GeneTree; ENSGT00940000155909; -. DR ChiTaRS; Grb10; mouse. DR Proteomes; UP000000589; Chromosome 11. DR Bgee; ENSMUSG00000020176; Expressed in associated mesenchyme of midgut and 261 other cell types or tissues. DR ExpressionAtlas; Q5SUW3; baseline and differential. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR CDD; cd16141; RA_GRB10; 1. DR CDD; cd10415; SH2_Grb10; 1. DR FunFam; 3.10.20.90:FF:000056; growth factor receptor-bound protein 10 isoform X1; 1. DR FunFam; 3.30.505.10:FF:000015; Growth factor receptor-bound protein 10 isoform X1; 1. DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1. DR Gene3D; 3.30.505.10; SH2 domain; 1. DR InterPro; IPR015042; BPS-dom. DR InterPro; IPR039664; GRB/APBB1IP. DR InterPro; IPR035037; Grb10_SH2. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR000159; RA_dom. DR InterPro; IPR000980; SH2. DR InterPro; IPR036860; SH2_dom_sf. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1. DR PANTHER; PTHR11243:SF4; GROWTH FACTOR RECEPTOR-BOUND PROTEIN 10; 1. DR Pfam; PF08947; BPS; 1. DR Pfam; PF21989; RA_2; 1. DR Pfam; PF00017; SH2; 1. DR PRINTS; PR00401; SH2DOMAIN. DR SMART; SM00314; RA; 1. DR SMART; SM00252; SH2; 1. DR SUPFAM; SSF55550; SH2 domain; 1. DR SUPFAM; SSF54236; Ubiquitin-like; 1. DR PROSITE; PS50200; RA; 1. DR PROSITE; PS50001; SH2; 1. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0007829|PeptideAtlas:Q5SUW3, KW ECO:0007829|ProteomicsDB:Q5SUW3}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE- KW ProRule:PRU00191}. FT DOMAIN 173..253 FT /note="Ras-associating" FT /evidence="ECO:0000259|PROSITE:PS50200" FT DOMAIN 449..545 FT /note="SH2" FT /evidence="ECO:0000259|PROSITE:PS50001" FT REGION 1..156 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..57 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 99..116 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 128..156 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 550 AA; 62259 MW; 9C5F174B6F02D593 CRC64; MNNDINSSVE SLNSACNMQS DTDTAPLLED GQHASNQGAA SSSRGQPQAS PRQKMQRSQP VHILRRLQEE DQQLRTASLP AIPNPFPELT GAAPGSPPSV APSSLPPPPS QPPAKHFPPG FQLSKLTRPG LWTKTTARFS KKQPKNQCPT DTVNPVARMP TSQMEKLRLR KDVKVFSEDG TSKVVEILTD MTARDLCQLL VYKSHCVDDN SWTLVEHHPQ LGLERCLEDH EIVVQVESTM PSESKFLFRK NYAKYEFFKN PVNFFPDQMV NWCQQSNGGQ AQLLQEPRHL QLLADLEESS IFYLIAGKKQ YNAPNEHGMC IKPNKAKTEM KELRLLCAED EQIRTCWMTA FRLLKYGMLL YQNYRIPQRK GLPPPFNAPM RSVSENSLVA MDFSGQIGRV IDNPAEAQSA ALEEGHAWRK RSTRMNILSS QSPLHPSTLN AVIHRTQHWF HGRISREESH RIIKQQGLVD GLFLLRDSQS NPKAFVLTLC HHQKIKNFQI LPCEDDGQTF FTLDDGNTKF SDLIQLVDFY QLNKGVLPCK LKHHCIRVAL //