ID Q5R5Z6_PONAB Unreviewed; 913 AA. AC Q5R5Z6; DT 21-DEC-2004, integrated into UniProtKB/TrEMBL. DT 21-DEC-2004, sequence version 1. DT 25-NOV-2008, entry version 21. DE RecName: Full=Ubiquitin carboxyl-terminal hydrolase; DE EC=3.1.2.15; GN Name=DKFZp459P1127; OS Pongo abelii (Sumatran orangutan). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Cortex; RG The German cDNA Consortium; RA Bloecker H., Boecher M., Brandt P., Mewes H.W., Weil B., Amid C., RA Osanger A., Fobo G., Han M., Wiemann S.; RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: Ubiquitin C-terminal thioester + H(2)O = CC ubiquitin + a thiol. CC -!- SIMILARITY: Belongs to the peptidase C19 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CR860704; CAH92820.1; -; mRNA. DR RefSeq; NP_001126647.1; -. DR GeneID; 100173645; -. DR HOVERGEN; Q5R5Z6; -. DR GO; GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0006512; P:ubiquitin cycle; IEA:InterPro. DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. DR InterPro; IPR006615; Pept_C19_DUSP. DR InterPro; IPR001394; Peptidase_C19. DR InterPro; IPR001607; Znf_UBP. DR Pfam; PF00443; UCH; 1. DR Pfam; PF02148; zf-UBP; 1. DR SMART; SM00695; DUSP; 2. DR PROSITE; PS51283; DUSP; 2. DR PROSITE; PS00972; UCH_2_1; 1. DR PROSITE; PS00973; UCH_2_2; 1. DR PROSITE; PS50235; UCH_2_3; 1. DR PROSITE; PS50271; ZF_UBP; 1. PE 2: Evidence at transcript level; KW Hydrolase; Protease; Thiol protease; Ubl conjugation pathway. SQ SEQUENCE 913 AA; 101851 MW; 54CA311FD1D3E626 CRC64; MGDSRDLCPH LDSIGEVTKE DLLLKSMGTC QSCGVTGPNL WACLQVACPY VGCGESFADH STIHAQAKKH NLTVNLTTFR LWCYACEKEV FLEQRLAAPL LGSSKFSEQD SPPPSHPLKA VPIAVADEGE SESEDDDLKP RGLTGMKNLG NSCYMNAALQ ALSNCPPLTQ FFLECGGLVR TDKKPALCKS YQKLVSEVWH KKRPSYVVPT SLSHGIKLVN PMFRGYAQQD TQEFLRCLMD QLHEELKEPV VATVALTEAR DSDSSDTDEK REGDRSPSED EFLSCDSSSD RGEGDGQGRG GGSSQAETEL LIPDEASRAI SEKERMKDRK FSWGQQRTNS EQVDEDADVD TTMAALDDQP AEAQPPSPRS SSPCRTPEPD NDAHLCSSSR PCSPVHHHEG HAKLSSSPPR ASPVRMAPSY VLKKAQVLSA GSRRRKEQRY RSVISDIFDG SILSLVQCLT CDRVSATVET FQDLSLPIPG KEDLAKLHSA IYQNVPAKPG TCGDSYAAQG WLAFIVEYIR RFVVSCTPSW FWGPVVTLED CLAAFFAADE LKGDNMYSCE RCKKLRNGVK YCKVLRLPEI LCIHLKRFRH EVMYSFKINS HVSFPLEGLD LRPFLAKECT SQITTYDLLS VICHHGTAGS GHYIAYCQNV INGQWYEFDD QYVTEVHETV VQNAEGYVLF YRKSSEEAVR ERQQVVSLAA MREPSLLRFY VSREWLNKFN TFAEPGPITN QTFLCSHGGI PPHKYHYIDD LVVILPQNVW EHLYNRFGGG PAVNHLYVCS ICQVEIEALA KRRRIEIDTF IKLNKAFQAE ESPGIIYCIS MQWFREWEAF VKGKDNEPPG PIDNSRIAQV KGSGHVQLKQ GADYGQISEE TWTYLNSLYG GGPEIAIRQS VAQPLGPESL HGEQKIEAEA RAV //