ID GP120_HUMAN Reviewed; 377 AA. AC Q5NUL3; Q5VY25; Q5VY26; Q7Z605; Q86SM7; DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot. DT 10-MAY-2005, sequence version 2. DT 15-MAY-2007, entry version 20. DE G-protein coupled receptor 120 (G-protein coupled receptor PGR4) (G- DE protein coupled receptor GT01) (G-protein coupled receptor 129). GN Name=GPR120; Synonyms=GPR129, PGR4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX MEDLINE=22985413; PubMed=14623098; DOI=10.1016/S0014-5793(03)01196-7; RA Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., RA Schioeth H.B.; RT "Seven evolutionarily conserved human rhodopsin G protein-coupled RT receptors lacking close relatives."; RL FEBS Lett. 554:381-388(2003). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND RP FUNCTION. RX PubMed=15619630; DOI=10.1038/nm1168; RA Hirasawa A., Tsumaya K., Awaji T., Katsuma S., Adachi T., Yamada M., RA Sugimoto Y., Miyazaki S., Tsujimoto G.; RT "Free fatty acids regulate gut incretin glucagon-like peptide-1 RT secretion through GPR120."; RL Nat. Med. 11:90-94(2005). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., RA Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 49-312 (ISOFORM 2). RX MEDLINE=22584407; PubMed=12679517; DOI=10.1073/pnas.0230374100; RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., RA Bergmann J.E., Gaitanaris G.A.; RT "The G protein-coupled receptor repertoires of human and mouse."; RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003). CC -!- FUNCTION: Receptor for unsaturated long-chain free fatty acid CC (FAA). Binding of the ligand promotes the secretion of glucagon- CC like peptide-1 from the gastro-intestinal tract. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q5NUL3-1; Sequence=Displayed; CC Name=2; CC IsoId=Q5NUL3-2; Sequence=VSP_013684; CC -!- TISSUE SPECIFICITY: Abundant expression in the intestinal tract. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY288417; AAP72126.1; -; mRNA. DR EMBL; AB115768; BAD83368.1; -; mRNA. DR EMBL; AL356214; CAH72326.1; -; Genomic_DNA. DR EMBL; AL356214; CAH72327.1; -; Genomic_DNA. DR EMBL; AY255573; AAO85085.1; -; mRNA. DR UniGene; Hs.677835; -. DR Ensembl; ENSG00000186188; Homo sapiens. DR KEGG; hsa:338557; -. DR HGNC; HGNC:19061; GPR120. DR MIM; 609044; gene. DR ArrayExpress; Q5NUL3; -. DR GermOnline; ENSG00000186188; Homo sapiens. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Gene3D; G3DSA:1.20.1070.10; G3DSA:1.20.1070.10; 1. DR PANTHER; PTHR19264; PTHR19264; 2. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW Alternative splicing; G-protein coupled receptor; Glycoprotein; KW Lipid-binding; Membrane; Receptor; Transducer; Transmembrane. FT CHAIN 1 377 G-protein coupled receptor 120. FT /FTId=PRO_0000069610. FT TOPO_DOM 1 45 Extracellular (Potential). FT TRANSMEM 46 66 1 (Potential). FT TOPO_DOM 67 77 Cytoplasmic (Potential). FT TRANSMEM 78 98 2 (Potential). FT TOPO_DOM 99 112 Extracellular (Potential). FT TRANSMEM 113 133 3 (Potential). FT TOPO_DOM 134 156 Cytoplasmic (Potential). FT TRANSMEM 157 177 4 (Potential). FT TOPO_DOM 178 204 Extracellular (Potential). FT TRANSMEM 205 225 5 (Potential). FT TOPO_DOM 226 284 Cytoplasmic (Potential). FT TRANSMEM 285 305 6 (Potential). FT TOPO_DOM 306 311 Extracellular (Potential). FT TRANSMEM 312 332 7 (Potential). FT TOPO_DOM 333 377 Cytoplasmic (Potential). FT COMPBIAS 67 71 Poly-Arg. FT CARBOHYD 21 21 N-linked (GlcNAc...) (Potential). FT VAR_SEQ 233 248 Missing (in isoform 2). FT /FTId=VSP_013684. FT CONFLICT 67 67 R -> C (in Ref. 2). FT CONFLICT 67 67 Missing (in Ref. 1). FT CONFLICT 274 274 Q -> H (in Ref. 2). FT CONFLICT 297 297 I -> T (in Ref. 2). SQ SEQUENCE 377 AA; 42241 MW; 28BB8C3A939A7EFF CRC64; MSPECARAAG DAPLRSLEQA NRTRFPFFSD VKGDHRLVLA AVETTVLVLI FAVSLLGNVC ALVLVARRRR RGATACLVLN LFCADLLFIS AIPLVLAVRW TEAWLLGPVA CHLLFYVMTL SGSVTILTLA AVSLERMVCI VHLQRGVRGP GRRARAVLLA LIWGYSAVAA LPLCVFFRVV PQRLPGADQE ISICTLIWPT IPGEISWDVS FVTLNFLVPG LVIVISYSKI LQTSEHLLDA RAVVTHSEIT KASRKRLTVS LAYSESHQIR VSQQDFRLFR TLFLLMVSFF IMWSPIIITI LLILIQNFKQ DLVIWPSLFF WVVAFTFANS ALNPILYNMT LCRNEWKKIF CCFWFPEKGA ILTDTSVKRN DLSIISG //