ID Q5NCU3_MOUSE Unreviewed; 172 AA. AC Q5NCU3; DT 05-FEB-2008, integrated into UniProtKB/TrEMBL. DT 05-FEB-2008, sequence version 1. DT 09-DEC-2015, entry version 56. DE SubName: Full=SPARC {ECO:0000313|Ensembl:ENSMUSP00000119475}; DE Flags: Fragment; GN Name=Sparc {ECO:0000313|Ensembl:ENSMUSP00000119475, GN ECO:0000313|MGI:MGI:98373}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000119475, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000119475, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119475, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000119475} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119475}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000119475}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL596207; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL772268; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; Q5NCU3; -. DR Ensembl; ENSMUST00000141530; ENSMUSP00000119475; ENSMUSG00000018593. DR MGI; MGI:98373; Sparc. DR GeneTree; ENSGT00510000046787; -. DR HOGENOM; HOG000088654; -. DR HOVERGEN; HBG002746; -. DR ChiTaRS; Sparc; mouse. DR NextBio; 35563948; -. DR Proteomes; UP000000589; Chromosome 11. DR Bgee; Q5NCU3; -. DR ExpressionAtlas; Q5NCU3; baseline and differential. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005615; C:extracellular space; IEA:InterPro. DR GO; GO:0016363; C:nuclear matrix; ISO:MGI. DR GO; GO:0031091; C:platelet alpha granule; ISO:MGI. DR GO; GO:0031092; C:platelet alpha granule membrane; ISO:MGI. DR GO; GO:0005578; C:proteinaceous extracellular matrix; IDA:MGI. DR GO; GO:0005509; F:calcium ion binding; ISO:MGI. DR GO; GO:0005518; F:collagen binding; ISO:MGI. DR GO; GO:0050840; F:extracellular matrix binding; IDA:MGI. DR GO; GO:0060348; P:bone development; IMP:MGI. DR GO; GO:0071363; P:cellular response to growth factor stimulus; IDA:MGI. DR GO; GO:0016525; P:negative regulation of angiogenesis; ISO:MGI. DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:MGI. DR GO; GO:0010595; P:positive regulation of endothelial cell migration; ISO:MGI. DR GO; GO:0022604; P:regulation of cell morphogenesis; ISO:MGI. DR GO; GO:0042127; P:regulation of cell proliferation; IGI:MGI. DR InterPro; IPR003645; Fol_N. DR InterPro; IPR015369; Follistatin/Osteonectin_EGF. DR InterPro; IPR002350; Kazal_dom. DR InterPro; IPR001999; Osteonectin_CS. DR Pfam; PF09289; FOLN; 1. DR Pfam; PF00050; Kazal_1; 1. DR SMART; SM00274; FOLN; 1. DR SMART; SM00280; KAZAL; 1. DR PROSITE; PS51465; KAZAL_2; 1. DR PROSITE; PS00612; OSTEONECTIN_1; 1. DR PROSITE; PS00613; OSTEONECTIN_2; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Proteomics identification {ECO:0000213|MaxQB:Q5NCU3, KW ECO:0000213|PeptideAtlas:Q5NCU3}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 172 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004260259. FT DOMAIN 91 148 Kazal-like. {ECO:0000259|PROSITE: FT PS51465}. FT NON_TER 172 172 {ECO:0000313|Ensembl:ENSMUSP00000119475}. SQ SEQUENCE 172 AA; 19096 MW; CAEEDC2D79984AF0 CRC64; MRAWIFFLLC LAGRALAAPT EVAEEIVEEE TVVEETGVPV GANPVQVEMG EFEDGAEETV EEVVADNPCQ NHHCKHGKVC ELDESNTPMC VCQDPTSCPA PIGEFEKVCS NDNKTFDSSC HFFATKCTLE GTKKGHKLHL DYIGPCKYIA PCLDSELTEF PLRMRDWLKN VL //