ID   DOP1_HUMAN              Reviewed;        2465 AA.
AC   Q5JWR5; Q86XV1; Q9H5J5; Q9NSL4; Q9UPN5; Q9Y414;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   24-JAN-2024, entry version 108.
DE   RecName: Full=Protein dopey-1 {ECO:0000305};
GN   Name=DOP1A {ECO:0000312|HGNC:HGNC:21194};
GN   Synonyms=DOPEY1 {ECO:0000312|HGNC:HGNC:21194}, KIAA1117;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 908-2465.
RC   TISSUE=Brain;
RX   PubMed=10470851; DOI=10.1093/dnares/6.3.197;
RA   Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A.,
RA   Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XIV. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 6:197-205(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1212-2465.
RC   TISSUE=Amygdala;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1326-2465.
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1910-2465.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   VARIANT [LARGE SCALE ANALYSIS] HIS-1155.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: May be involved in protein traffic between late Golgi and
CC       early endosomes. {ECO:0000250|UniProtKB:Q03921}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q03921}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q03921}.
CC   -!- SIMILARITY: Belongs to the dopey family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB15631.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL121716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL139333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB029040; BAA83069.2; -; mRNA.
DR   EMBL; AL050080; CAB43259.1; -; mRNA.
DR   EMBL; AL162056; CAB82395.1; -; mRNA.
DR   EMBL; AK027030; BAB15631.1; ALT_INIT; mRNA.
DR   EMBL; BC048342; AAH48342.1; -; mRNA.
DR   CCDS; CCDS4996.1; -.
DR   PIR; T47141; T47141.
DR   RefSeq; NP_055833.2; NM_015018.3.
DR   RefSeq; XP_016866052.1; XM_017010563.1.
DR   RefSeq; XP_016866053.1; XM_017010564.1.
DR   AlphaFoldDB; Q5JWR5; -.
DR   BioGRID; 116672; 15.
DR   IntAct; Q5JWR5; 6.
DR   STRING; 9606.ENSP00000237163; -.
DR   GlyGen; Q5JWR5; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q5JWR5; -.
DR   PhosphoSitePlus; Q5JWR5; -.
DR   BioMuta; DOPEY1; -.
DR   DMDM; 156630499; -.
DR   EPD; Q5JWR5; -.
DR   jPOST; Q5JWR5; -.
DR   MassIVE; Q5JWR5; -.
DR   MaxQB; Q5JWR5; -.
DR   PaxDb; 9606-ENSP00000237163; -.
DR   PeptideAtlas; Q5JWR5; -.
DR   ProteomicsDB; 63399; -.
DR   Pumba; Q5JWR5; -.
DR   Antibodypedia; 31656; 58 antibodies from 15 providers.
DR   DNASU; 23033; -.
DR   Ensembl; ENST00000349129.7; ENSP00000195654.3; ENSG00000083097.15.
DR   GeneID; 23033; -.
DR   KEGG; hsa:23033; -.
DR   MANE-Select; ENST00000349129.7; ENSP00000195654.3; NM_015018.4; NP_055833.2.
DR   UCSC; uc003pjs.2; human.
DR   AGR; HGNC:21194; -.
DR   CTD; 23033; -.
DR   DisGeNET; 23033; -.
DR   GeneCards; DOP1A; -.
DR   HGNC; HGNC:21194; DOP1A.
DR   HPA; ENSG00000083097; Low tissue specificity.
DR   MalaCards; DOP1A; -.
DR   neXtProt; NX_Q5JWR5; -.
DR   OpenTargets; ENSG00000083097; -.
DR   PharmGKB; PA134924787; -.
DR   VEuPathDB; HostDB:ENSG00000083097; -.
DR   eggNOG; KOG3613; Eukaryota.
DR   GeneTree; ENSGT00390000016421; -.
DR   InParanoid; Q5JWR5; -.
DR   OrthoDB; 23089at2759; -.
DR   PhylomeDB; Q5JWR5; -.
DR   TreeFam; TF316855; -.
DR   PathwayCommons; Q5JWR5; -.
DR   SignaLink; Q5JWR5; -.
DR   BioGRID-ORCS; 23033; 8 hits in 1144 CRISPR screens.
DR   ChiTaRS; DOPEY1; human.
DR   GenomeRNAi; 23033; -.
DR   Pharos; Q5JWR5; Tdark.
DR   PRO; PR:Q5JWR5; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q5JWR5; Protein.
DR   Bgee; ENSG00000083097; Expressed in calcaneal tendon and 193 other cell types or tissues.
DR   ExpressionAtlas; Q5JWR5; baseline and differential.
DR   Genevisible; Q5JWR5; HS.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005798; C:Golgi-associated vesicle; IEA:Ensembl.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:0006895; P:Golgi to endosome transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR040314; DOP1.
DR   InterPro; IPR007249; Dopey_N.
DR   PANTHER; PTHR14042; DOPEY-RELATED; 1.
DR   PANTHER; PTHR14042:SF22; PROTEIN DOPEY-1; 1.
DR   Pfam; PF04118; Dopey_N; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Phosphoprotein; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..2465
FT                   /note="Protein dopey-1"
FT                   /id="PRO_0000297947"
FT   REGION          559..600
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          625..646
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          705..733
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1282..1315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        566..586
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        628..646
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        710..733
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1300..1315
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1266
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BL99"
FT   VARIANT         596
FT                   /note="R -> Q (in dbSNP:rs4706980)"
FT                   /id="VAR_034690"
FT   VARIANT         1155
FT                   /note="D -> H (in a breast cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_036607"
FT   VARIANT         1781
FT                   /note="Q -> L (in dbSNP:rs9444039)"
FT                   /id="VAR_034691"
SQ   SEQUENCE   2465 AA;  277355 MW;  97C58882414BAA6E CRC64;
     MNTEELELLS DSKYRNYVAA IDKALKNFEY SSEWADLISA LGKLNKVLQN NAKYQVVPKK
     LTIGKRLAQC LHPALPGGVH RKALETYEII FKIIGPKRLA KDLFLYSSGL FPLLANAAMS
     VKPTLLSLYE IYYLPLGKTL KPGLQGLLTG ILPGLEEGSE YYERTNMLLE KVAAAVDQSA
     FYSALWGSLL TSPAVRLPGI TYVLAHLNRK LSMEDQLYII GSDIELMVEA VSTSVQDSSV
     LVQRSTLDLI LFCFPFHMSQ ATRPDMIRIL SAALHVVLRR DMSLNRRLYA WLLGFDNNGA
     IIGPRSTRHS NPEEHATYYF TTFSKELLVQ AMVGILQVNG FGEENTLMQD LKPFRILISL
     LDKPELGPVI LEDVLIEVFR TLYSQCKAEL DLQTEPPFSK DHAQLSSKLR ENKKTAELIK
     TANLLFNSFE PYYMWDYVAR WFEECCRRTL HVRLQIGPGD SNDSSELQLT NFCLLVDFLL
     DIVSLPTRSM RVLCQETYIE IQTEHLPQLL LRMISALTSH LQTLHLSELT DSLRLCSKIL
     SKVQPPLLSA STGGVLQFPS GQNNSVKEWE DKKVSSVSHE NPTEVFEDGE NPPSSRSSES
     GFTEFIQYQA DRTDDIDREL SEGQGAAAIP IGSTSSETET ASTVGSEETI IQTPSVVTQG
     TATRSRKTAQ KTAMQCCLEY VQQFLTRLIN LYIIQNNSFS QSLATEHQGD LGREQGETSK
     WDRNSQGDVK EKNISKQKTS KEYLSAFLAA CQLFLECSSF PVYIAEGNHT SELRSEKLET
     DCEHVQPPQW LQTLMNACSQ ASDFSVQSVA ISLVMDLVGL TQSVAMVTGE NINSVEPAQP
     LSPNQGRVAV VIRPPLTQGN LRYIAEKTEF FKHVALTLWD QLGDGTPQHH QKSVELFYQL
     HNLVPSSSIC EDVISQQLTH KDKKIRMEAH AKFAVLWHLT RDLHINKSSS FVRSFDRSLF
     IMLDSLNSLD GSTSSVGQAW LNQVLQRHDI ARVLEPLLLL LLHPKTQRVS VQRVQAERYW
     NKSPCYPGEE SDKHFMQNFA CSNVSQVQLI TSKGNGEKPL TMDEIENFSL TVNPLSDRLS
     LLSTSSETIP MVVSDFDLPD QQIEILQSSD SGCSQSSAGD NLSYEVDPET VNAQEDSQMP
     KESSPDDDVQ QVVFDLICKV VSGLEVESAS VTSQLEIEAM PPKCSDIDPD EETIKIEDDS
     IQQSQNALLS NESSQFLSVS AEGGHECVAN GISRNSSSPC ISGTTHTLHD SSVASIETKS
     RQRSHSSIQF SFKEKLSEKV SEKETIVKES GKQPGAKPKV KLARKKDDDK KKSSNEKLKQ
     TSVFFSDGLD LENWYSCGEG DISEIESDMG SPGSRKSPNF NIHPLYQHVL LYLQLYDSSR
     TLYAFSAIKA ILKTNPIAFV NAISTTSVNN AYTPQLSLLQ NLLARHRISV MGKDFYSHIP
     VDSNHNFRSS MYIEILISLC LYYMRSHYPT HVKVTAQDLI GNRNMQMMSI EILTLLFTEL
     AKVIESSAKG FPSFISDMLS KCKVQKVILH CLLSSIFSAQ KWHSEKMAGK NLVAVEEGFS
     EDSLINFSED EFDNGSTLQS QLLKVLQRLI VLEHRVMTIP EENETGFDFV VSDLEHISPH
     QPMTSLQYLH AQPITCQGMF LCAVIRALHQ HCACKMHPQW IGLITSTLPY MGKVLQRVVV
     SVTLQLCRNL DNLIQQYKYE TGLSDSRPLW MASIIPPDMI LTLLEGITAI IHYCLLDPTT
     QYHQLLVSVD QKHLFEARSG ILSILHMIMS SVTLLWSILH QADSSEKMTI AASASLTTIN
     LGATKNLRQQ ILELLGPISM NHGVHFMAAI AFVWNERRQN KTTTRTKVIP AASEEQLLLV
     ELVRSISVMR AETVIQTVKE VLKQPPAIAK DKKHLSLEVC MLQFFYAYIQ RIPVPNLVDS
     WASLLILLKD SIQLSLPAPG QFLILGVLNE FIMKNPSLEN KKDQRDLQDV THKIVDAIGA
     IAGSSLEQTT WLRRNLEVKP SPKIMVDGTN LESDVEDMLS PAMETANITP SVYSVHALTL
     LSEVLAHLLD MVFYSDEKER VIPLLVNIMH YVVPYLRNHS AHNAPSYRAC VQLLSSLSGY
     QYTRRAWKKE AFDLFMDPSF FQMDASCVNH WRAIMDNLMT HDKTTFRDLM TRVAVAQSSS
     LNLFANRDVE LEQRAMLLKR LAFAIFSSEI DQYQKYLPDI QERLVESLRL PQVPTLHSQV
     FLFFRVLLLR MSPQHLTSLW PTMITELVQV FLLMEQELTA DEDISRTSGP SVAGLETTYT
     GGNGFSTSYN SQRWLNLYLS ACKFLDLALA LPSENLPQFQ MYRWAFIPEA SDDSGLEVRR
     QGIHQREFKP YVVRLAKLLR KRAKKNPEED NSGRTLGWEP GHLLLTICTV RSMEQLLPFF
     NVLSQVFNSK VTSRCGGHSG SPILYSNAFP NKDMKLENHK PCSSKARQKI EEMVEKDFLE
     GMIKT
//