ID Q5JRY3_HUMAN Unreviewed; 157 AA. AC Q5JRY3; DT 15-FEB-2005, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 2. DT 05-DEC-2018, entry version 90. DE SubName: Full=Transcription factor 7-like 2 {ECO:0000313|Ensembl:ENSP00000358393}; DE Flags: Fragment; GN Name=TCF7L2 {ECO:0000313|Ensembl:ENSP00000358393}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000358393, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000358393, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., RA Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000358393} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL135792; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL158212; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL445486; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL451084; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; Q5JRY3; -. DR PeptideAtlas; Q5JRY3; -. DR PRIDE; Q5JRY3; -. DR Ensembl; ENST00000369386; ENSP00000358393; ENSG00000148737. DR UCSC; uc057wbh.1; human. DR EuPathDB; HostDB:ENSG00000148737.15; -. DR HGNC; HGNC:11641; TCF7L2. DR OpenTargets; ENSG00000148737; -. DR GeneTree; ENSGT00940000155535; -. DR HOGENOM; HOG000116032; -. DR HOVERGEN; HBG000419; -. DR ChiTaRS; TCF7L2; human. DR Proteomes; UP000005640; Chromosome 10. DR Bgee; ENSG00000148737; Expressed in 228 organ(s), highest expression level in lateral nuclear group of thalamus. DR ExpressionAtlas; Q5JRY3; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0016055; P:Wnt signaling pathway; IEA:InterPro. DR Gene3D; 1.10.30.10; -; 1. DR InterPro; IPR009071; HMG_box_dom. DR InterPro; IPR036910; HMG_box_dom_sf. DR InterPro; IPR024940; TCF/LEF. DR PANTHER; PTHR10373; PTHR10373; 1. DR Pfam; PF00505; HMG_box; 1. DR SMART; SM00398; HMG; 1. DR SUPFAM; SSF47095; SSF47095; 1. DR PROSITE; PS50118; HMG_BOX_2; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267}; KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267}; KW Proteomics identification {ECO:0000213|EPD:Q5JRY3, KW ECO:0000213|MaxQB:Q5JRY3, ECO:0000213|PeptideAtlas:Q5JRY3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 30 98 HMG box. {ECO:0000259|PROSITE:PS50118}. FT DNA_BIND 30 98 HMG box. {ECO:0000256|PROSITE-ProRule: FT PRU00267}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000358393}. SQ SEQUENCE 157 AA; 18297 MW; CB00A6CED4938D18 CRC64; QESSQSDVGS LHSSKHQDSK KEEEKKKPHI KKPLNAFMLY MKEMRAKVVA ECTLKESAAI NQILGRRWHA LSREEQAKYY ELARKERQLH MQLYPGWSAR DNYGKKKKRK RDKQPGETND LSAPKKCRAR FGLDQQNNWC GPCRCKYSKE VSGTVRA //